The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
Renoprotective Effect of Calcium Channel Blockers in Combination with an Angiotensin Receptor Blocker in Elderly Patients with Hypertension. A Randomized Crossover Trial Between Benidipine and Amlodipine
Abstract
Anti-hypertensive medication with an angiotensin II receptor blocker (ARB) is effective in slowing the progression of chronic kidney disease. The present study was designed to investigate whether calcium channel blockers (CCBs) in combination with an ARB differentially affect kidney function. Elderly hypertensive patients with chronic kidney disease (n = 17, 72 +/- 6 years old) were instructed to self-measure blood pressure. They were randomly assigned to receive either benidipine (4-8 mg/day) or amlodipine (5-10 mg/day) combined with olmesartan (10 mg/day). After 3 months, CCBs were switched in each patient and the same protocol was applied for another 3 months. At baseline, significant correlation was obtained between urine albumin (22.8 +/- 16.7 (median +/- median absolute deviation) mg/g creatinine) and self-measured blood pressure (170 +/- 23/87 +/- 10 (mean +/- SD) mmHg, r = 0.65, p < 0.01). Both regimens reduced blood pressure to a similar extent (139 +/- 22/75 +/- 11 mmHg and 133 +/- 17/72 +/- 10 mmHg, respectively; both p < 0.001), while urine albumin decreased only after combination therapy including benidipine (11.7 +/- 6.1 mg/g creatinine, p < 0.05). Benidipine, but not amlodipine, in combination with olmesartan, reduced urinary albumin excretion in elderly hypertensive patients with chronic kidney disease. The results suggest the importance of selecting medications used in combination with ARB in hypertensive patients with chronic kidney disease.
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Chobanian, A. V. (2003) · JAMA · doi:10.1001/jama.289.19.2560 · Cited by 25,386
2013 ESH/ESC Guidelines for the management of arterial hypertension
Authors Task Force Members, Mancia, G., Fagard, R., Narkiewicz, K., Redon, J., Zanchetti, A., Böhm, M., Christiaens, T., Cífková, R., Backer, G. D., et al. (2013) · European Heart Journal · doi:10.1093/eurheartj/eht151 · Cited by 13,764
Mancia, G., Backer, G. D., Dominiczak, A. F., Cífková, R., Fagard, R. H., Germanò, G., Grassi, G. M., Heagerty, A. M., Kjeldsen, S. E., Laurent, S., et al. (2007) · Journal of Hypertension · doi:10.1097/hjh.0b013e3281fc975a · Cited by 5,906
Gerstein, H. C. (2001) · JAMA · doi:10.1001/jama.286.4.421 · Cited by 2,440
Turner, R. D., & Holman, R. R. (1998) · Cited by 1,974
Blood Pressure and End-Stage Renal Disease in Men
Klag, M. J., Whelton, P. K., Randall, B. L., Neaton, J. D., Brancati, F. L., Ford, C. E., Shulman, N. B., & Stamler, J. (1996) · New England Journal of Medicine · doi:10.1056/nejm199601043340103 · Cited by 1,661
Blood Pressure Control, Proteinuria, and the Progression of Renal Disease
Peterson, J. C., Adler, S., Burkart, J. M., Greene, T., Hebert, L. A., Hunsicker, L. G., King, A. J., Klahr, S., Massry, S. G., Seifter, J. L., et al. (1995) · Annals of Internal Medicine · doi:10.7326/0003-4819-123-10-199511150-00003 · Cited by 1,325
Staessen, J. A., Gąsowski, J., Wang, J. G., Thijs, L., Hond, E. D., Boissel, J., Coope, J., Ekbom, T., Gueyffier, F., Liu, L., et al. (2000) · The Lancet · doi:10.1016/s0140-6736(99)07330-4 · Cited by 1,159
Research works printed but not linked: 3
- 10.1001/jama.1992.03490210067037 · DOI
- Fleming JT, 1987, Am J Physiol, 253, F1157
- Carmines PK, 1989, Am J Physiol, 256, F1015
Cited by
Agarwal, R., Bills, J. E., Hecht, T. J. W., & Light, R. P. (2011) · Hypertension · doi:10.1161/hypertensionaha.110.160911 · Cited by 430
Kidney aging—inevitable or preventable?
Choudhury, D., & Levi, M. (2011) · Nature Reviews Nephrology · doi:10.1038/nrneph.2011.104 · Cited by 85
Ponticelli, C. E., Sala, G., & Glassock, R. J. (2015) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2015.01.016 · Cited by 57
Thamcharoen, N., Susantitaphong, P., Wongrakpanich, S., Chongsathidkiet, P., Tantrachoti, P., Pitukweerakul, S., Avihingsanon, Y., Praditpornsilpa, K., Jaber, B. L., & Eiam‐Ong, S. (2015) · Hypertension Research · doi:10.1038/hr.2015.69 · Cited by 33
Chitotriosidase activity predicts endothelial dysfunction in type-2 diabetes mellitus
Sönmez, A., Haymana, C., Tapan, S., Safer, U., Çelebi, G., Ozturk, O., Genç, H., Doğru, T., Taşçı, İ., Erdem, G., et al. (2010) · Endocrine · doi:10.1007/s12020-010-9334-4 · Cited by 32
Metadata
- Authors
- Miyagawa, K., Dohi, Y., Nakazawa, A., Sugiura, T., Yamashita, S., Sato, K., & Kimura, G.
- Affiliations
- Nagoya City University (JP)
- Corresponding author
- Dohi, Yasuaki
- Venue
- Clinical and Experimental Hypertension
- Publisher
- Informa UK Limited
- Published
- 2010-02
- Volume
- 32
- Issue
- 1
- Pages
- 1-7
- ISSN
- 0148-3927 (ISSN-L)
- 1064-1963
- 1525-6006
- OpenAlex
- W2111641755
- Cited by
- 14
- References
- 51
- Citations by year
- 2025: 1 · 2020: 1 · 2016: 1 · 2015: 2 · 2013: 1 · 2012: 1
- FWCI
- 1.98
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical and Experimental Hypertension (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Keywords
- renal protection, calcium channel blockers, angiotensin receptor blockers, benidipine, amlodipine, olmesartan, chronic kidney disease, hypertension, elderly patients, urinary albumin excretion, combination antihypertensive therapy, blood pressure reduction
- MeSH terms
- Aged, Aged, 80 and over, Albuminuria, Antihypertensive Agents, Blood Pressure, Calcium Channel Blockers, Dihydropyridines, Drug Therapy, Combination, Female, Humans, Hypertension, Imidazoles, Male, Tetrazoles, Amlodipine, Cross-Over Studies, Angiotensin II Type 1 Receptor Blockers, Renal Insufficiency, Chronic
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