Antihypertensive Action of Melatonin in the Spontaneously Hypertensive Rat
Abstract
The effects of melatonin on blood pressure and heart rate were studied in 23-week-old male spontaneously hypertensive rats. Melatonin infused i.p. at a dose of 6 mg/rat per day for 5 days using an osmotic minipump produced a significant reduction of blood pressure and a slight but significant decrease of heart rate in the conscious and unrestrained state. These cardiovascular effects of melatonin developed gradually. Plasma renin concentration tended to decrease after melatonin treatment. These results demonstrate that melatonin has an antihypertensive action. The mechanism of the antihypertensive action of melatonin requires further study.
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Melatonin reduces arterial blood pressure in normal and hypertensive rats.
“Melatonin has been reported to reduce arterial blood pressure in normal and hypertensive rats (Kawashima et al. 1987; Chuang et al. 1993; K-Laflamme et al. 1998).”
From Melatonin attenuates the sympathetic nerve responses to orthostatic stress in humans (2003) · cites this paper as Kawashima et al. 1987
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Prolonged melatonin administration decreases nocturnal blood pressure in women
CAGNACCI, A., CANNOLETTA, M., RENZI, A., BALDASSARI, F., ARANGINO, S., & VOLPE, A. (2005) · American Journal of Hypertension · doi:10.1016/j.amjhyper.2005.05.008 · Cited by 156 · see citing works
Fabbian, F., Smolensky, M. H., Tiseo, R., Pala, M., Manfredini, R., & Portaluppi, F. (2013) · Chronobiology International · doi:10.3109/07420528.2012.715872 · Cited by 147 · see citing works
K.-Laflamme, A. (1998) · American Journal of Hypertension · doi:10.1016/s0895-7061(97)00401-9 · Cited by 97 · see citing works
Melatonin attenuates the sympathetic nerve responses to orthostatic stress in humans
Ray, C. A. (2003) · The Journal of Physiology · doi:10.1111/j.1469-7793.2003.01043.x · Cited by 51 · see citing works
- Authors
- Kawashima, K., Miwa, Y., Fujimoto, K., Oohata, H., Nishino, H., & Koike, H.
- Affiliations
- Daiichi-Sankyo (Japan) (JP)
- Venue
- Clinical and Experimental Hypertension. Part A: Theory and Practice
- Publisher
- Informa UK Limited
- Published
- 1987-01
- Volume
- 9
- Issue
- 7
- Pages
- 1121-1131
- ISSN
- 0148-3927 (ISSN-L)
- 0730-0077
- OpenAlex
- W2083271136
- Cited by
- 75
- References
- 0
- Citations by year
- 2023: 2 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 1 · 2016: 2 · 2015: 1 · 2014: 3 · 2012: 6
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical and Experimental Hypertension (publishedVersion)
- PubMed (publishedVersion)
- KeiO Associated Repository of Academic Resources (Keio University) (submittedVersion)
- Funders
- Suzuken Memorial Foundation
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Keywords
- melatonin, antihypertensive effect, spontaneously hypertensive rats, blood pressure, heart rate, plasma renin concentration, hypertension, cardiovascular effects
- MeSH terms
- Animals, Antihypertensive Agents, Heart Rate, Hypertension, Male, Melatonin, Rats, Inbred SHR, Renin, Rats
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