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Cited by 156Circadian rhythm and melatoninBlood Pressure and Hypertension StudiesHeart Rate Variability and Autonomic Control

Prolonged melatonin administration decreases nocturnal blood pressure in women

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CAGNACCI, A, CANNOLETTA, M, RENZI, A, BALDASSARI, F, ARANGINO, S, VOLPE, A·2005·American Journal of Hypertension
DOI 10.1016/j.amjhyper.2005.05.008
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Abstract

BACKGROUND: The nocturnal decline of blood pressure (BP) is almost coincident with the elevation of melatonin, which may exert vasodilatating and hypotensive effects. In this study we investigated whether prolonged nocturnal administration of melatonin could influence the daily rhythm of BP in women. METHODS: In a randomized double-blind study, 18 women, 47 to 63 years of age and with normal BP (N = 9) or treated essential hypertension (N = 9), received a 3-week course of a slow-release melatonin pill (3 mg) or placebo 1 h before going to bed. They were then crossed over to the other treatment for another 3 weeks. In each woman ambulatory BP was recorded for 41 h at baseline at the end of each treatment period. RESULTS: In comparison with placebo, melatonin administration did not influence diurnal BP but did significantly decrease nocturnal systolic (-3.77 +/- 1.7 mm Hg, P = .0423), diastolic (-3.63 +/- 1.3 mm Hg, P = .0153), and mean (-3.71 +/- 1.3 mm Hg, P = .013) BP without modifying heart rate. The effect was inversely related to the day-night difference in BP. CONCLUSION: These data indicate that prolonged administration of melatonin may improve the day-night rhythm of BP, particularly in women with a blunted nocturnal decline.

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  • The blood pressure lowering effect of melatonin after repeated administration in hypertensive patients has been replicated by others.

    “The blood pressure lowering effect of melatonin after repeated administration in hypertensive patients has been replicated by others (Cagnacci et al., 2005; Grossman et al., 2006).”

    From The impact of the circadian timing system on cardiovascular and metabolic function (2012) · cites this paper as Cagnacci et al., 2005

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Authors
CAGNACCI, A., CANNOLETTA, M., RENZI, A., BALDASSARI, F., ARANGINO, S., & VOLPE, A.
Affiliations
  • Azienda Ospedaliero-Universitaria di Modena (IT)
  • Azienda Unita' Sanitaria Locale Di Modena (IT)
Corresponding author
CAGNACCI, A
ORCID
Venue
American Journal of Hypertension
Publisher
Oxford University Press (OUP)
Published
2005-12
Volume
18
Issue
12
Pages
1614-1618
ISSN
0895-7061 (ISSN-L)
DOI
10.1016/j.amjhyper.2005.05.008
OpenAlex
W1979626105
Cited by
156
References
30
Citations by year
2026: 2 · 2025: 3 · 2024: 9 · 2023: 8 · 2022: 9 · 2021: 9 · 2020: 4 · 2019: 12 · 2018: 8 · 2017: 6 · 2016: 3 · 2015: 5 · 2014: 13 · 2013: 8 · 2012: 10
FWCI
2.32
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • American Journal of Hypertension (publishedVersion)
  • PubMed (publishedVersion)
  • Institutional Research Information System (University of Udine) (submittedVersion)
  • CINECA IRIS Institutial Research Information System (University of Genoa) (submittedVersion)
  • IRIS UNIMORE (University of Modena and Reggio Emilia) (submittedVersion, cc-by)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
Keywords
melatonin, nocturnal blood pressure, blood pressure rhythm, essential hypertension, women, ambulatory blood pressure monitoring, vasodilation, heart rate
MeSH terms
Administration, Oral, Angiotensin-Converting Enzyme Inhibitors, Antihypertensive Agents, Blood Pressure, Circadian Rhythm, Delayed-Action Preparations, Double-Blind Method, Female, Humans, Hypertension, Melatonin, Middle Aged

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