Cited by 147Circadian rhythm and melatoninBlood Pressure and Hypertension StudiesHeart Rate Variability and Autonomic Control

Dipper and Non-Dipper Blood Pressure 24-Hour Patterns: Circadian Rhythm–Dependent Physiologic and Pathophysiologic Mechanisms

Fabbian, Fabio, Smolensky, Michael H., Tiseo, Ruana, Pala, Marco, Manfredini, Roberto, Portaluppi, Francesco·2013·Chronobiology International

Abstract

Neuroendocrine mechanisms are major determinants of the normal 24-h blood pressure (BP) pattern. At the central level, integration of the major driving factors of this temporal variability is mediated by circadian rhythms of monoaminergic systems in conjunction with those of the hypothalamic-pituitary-adrenal, hypothalamic-pituitary-thyroid, opioid, renin-angiotensin-aldosterone, plus endothelial systems and specific vasoactive peptides. Humoral secretions are typically episodic, coupled either to sleep and/or the circadian endogenous (suprachiasmatic nucleus) central pacemaker clock, but exhibiting also weekly, monthly, seasonal, and annual periodicities. Sleep induction and arousal are influenced also by many hormones and chemical substances that exhibit 24-h variation, e.g., arginine vasopressin, vasoactive intestinal peptide, melatonin, somatotropin, insulin, steroids, serotonin, corticotropin-releasing factor, adrenocorticotropic hormone, thyrotropin-releasing hormone, endogenous opioids, and prostaglandin E2, all with established effects on the cardiovascular system. As a consequence, physical, mental, and pathologic stimuli that activate or inhibit neuroendocrine effectors of biological rhythmicity may also interfere with, or modify, the temporal BP structure. Moreover, immediate adjustment to exogenous components/environment demands by BP rhythms is modulated by the circadian-time-dependent responsiveness of biological oscillators and their neuroendocrine effectors. This knowledge contributes to a better understanding of the pathophysiology of abnormalities of the 24-h BP pattern and level and their correction through circadian rhythm-based chronotherapeutic strategies.

Integrity signals

Registry

Crossref · 10.3109/07420528.2012.715872

Cites

225 of 225 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • In most healthy subjects, there is diurnal variation in blood pressure that parallels the circadian variation of blood pressure regulating systems such as sympathetic activity, cortisol and aldosterone.

    “In most healthy subjects, there is diurnal variation in blood pressure with systolic and diastolic blood pressures which parallels, in general, the circadian variation of blood pressure regulating systems such as sympathetic activity, cortisol and aldosterone 62.”

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Fabbian, F., Smolensky, M. H., Tiseo, R., Pala, M., Manfredini, R., & Portaluppi, F.
Affiliations
  • University of Ferrara (IT)
  • The University of Texas at Austin (US)
Corresponding author
Portaluppi, Francesco
Venue
Chronobiology International
Published
2012-09-24
Volume
30
Issue
1-2
Pages
17-30
ISSN
  • 0742-0528 (ISSN-L)
  • 1525-6073
OpenAlex
W1992744537
Cited by
147
References
225
Citations by year
2026: 3 · 2025: 8 · 2024: 7 · 2023: 11 · 2022: 5 · 2021: 18 · 2020: 14 · 2019: 7 · 2018: 10 · 2017: 10 · 2016: 12 · 2015: 17 · 2014: 11 · 2013: 10 · 2012: 4
FWCI
5.90
Type
journal article
Language
en
Open access
closed
Locations
  • Chronobiology International (publishedVersion)
  • PubMed (publishedVersion)
  • Institutional Research Information System University of Ferrara (University of Ferrara) (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
Keywords
non-dipping blood pressure, circadian rhythm, neuroendocrine regulation, monoaminergic systems, hypothalamic-pituitary-adrenal axis, renin-angiotensin-aldosterone system, vasoactive peptides, suprachiasmatic nucleus, chronotherapy, hypertension pathophysiology
MeSH terms
Adrenal Glands, Analgesics, Opioid, Animals, Autonomic Nervous System, Blood Pressure, Cardiovascular Diseases, Circadian Rhythm, Humans, Hypothalamus, Kidney, Pituitary Gland, Renin-Angiotensin System, Seasons, Sleep, Thyroid Gland, Time Factors, Blood Pressure Monitoring, Ambulatory

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review