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Cited by 453

The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.

Role of oxidative damage in toxicity of particulates

Møller, Peter, Jacobsen, Nicklas R., Folkmann, Janne K., Danielsen, Pernille H., Mikkelsen, Lone, Hemmingsen, Jette G., Vesterdal, Lise K., Forchhammer, Lykke, Wallin, Håkan, Loft, Steffen·2010·Free Radical Research

Abstract

Particulates are small particles of solid or liquid suspended in liquid or air. In vitro studies show that particles generate reactive oxygen species, deplete endogenous antioxidants, alter mitochondrial function and produce oxidative damage to lipids and DNA. Surface area, reactivity and chemical composition play important roles in the oxidative potential of particulates. Studies in animal models indicate that particles from combustion processes (generated by combustion of wood or diesel oil), silicate, titanium dioxide and nanoparticles (C60 fullerenes and carbon nanotubes) produce elevated levels of lipid peroxidation products and oxidatively damaged DNA. Biomonitoring studies in humans have shown associations between exposure to air pollution and wood smoke particulates and oxidative damage to DNA, deoxynucleotides and lipids measured in leukocytes, plasma, urine and/or exhaled breath. The results indicate that oxidative stress and elevated levels of oxidatively altered biomolecules are important intermediate endpoints that may be useful markers in hazard characterization of particulates.

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Metadata

Authors
Møller, P., Jacobsen, N. R., Folkmann, J. K., Danielsen, P. H., Mikkelsen, L., Hemmingsen, J. G., Vesterdal, L. K., Forchhammer, L., Wallin, H., & Loft, S.
Venue
Free Radical Research
Published
2009-11-03
Volume
44
Issue
1
Pages
1-46
ISSN
  • 1029-2470 (ISSN-L)
  • 1071-5762
OpenAlex
W2114477244
Cited by
453
References
7
FWCI
17.57
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Role of oxidative damage in toxicity of particulates. https://app.cochat.ai/papers/10.3109/10715760903300691
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Møller, P., Jacobsen, N. R., Folkmann, J. K., Danielsen, P. H., Mikkelsen, L., Hemmingsen, J. G., Vesterdal, L. K., Forchhammer, L., Wallin, H., & Loft, S. (2010). Role of oxidative damage in toxicity of particulates. Free Radical Research. https://doi.org/10.3109/10715760903300691

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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