Nitric oxide influences red blood cell velocity independently of changes in the vascular tone
Abstract
Nitric oxide (NO) plays a key role in regulation of vascular tone and blood flow. In the microcirculation blood flow is strongly dependent on red blood cells (RBC) deformability. In vitro NO increases RBC deformability. This study hypothesized that NO increases RBC velocity in vivo not only by regulating vascular tone, but also by modifying RBC deformability. The effects of NO on RBC velocity were analysed by intra-vital microscopy in the microcirculation of the chorioallantoic membrane (CAM) of the avian embryo at day 7 post-fertilization, when all vessels lack smooth muscle cells and vascular tone is not affected by NO. It was found that inhibition of enzymatic NO synthesis and NO scavenging decreased intracellular NO levels and avian RBC deformability in vitro. Injection of a NO synthase-inhibitor or a NO scavenger into the microcirculation of the CAM decreased capillary RBC velocity and deformation, while the diameter of the vessels remained constant. The results indicate that scavenging of NO and inhibition of NO synthesis decrease RBC velocity not only by regulating vascular tone but also by decreasing RBC deformability.
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In the microcirculation of the chorioallantoic membrane of the chicken egg, eNOS inhibition and NO donors affect RBC deformation and velocity independently from changes of vascular diameter.
“In microcirculation of the chorioallantoic membrane of the chicken egg, eNOS inhibition and NO donors affected RBC deformation and velocity independently from changes of the vascular diameter (82)”
From Red Blood Cell Function and Dysfunction: Redox Regulation, Nitric Oxide Metabolism, Anemia (2017) · cites this paper as [82]
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- Authors
- Horn, P., Cortese-Krott, M. M., Keymel, S., Kumara, I., Burghoff, S., Schrader, J., Kelm, M., & Kleinbongard, P.
- Affiliations
- Heinrich Heine University Düsseldorf (DE)
- Stiftung Universitätsmedizin Essen (DE)
- Corresponding author
- Kelm, Malte
- Venue
- Free Radical Research
- Publisher
- Informa UK Limited
- Published
- 2011-04-11
- Volume
- 45
- Issue
- 6
- Pages
- 653-661
- ISSN
- 1029-2470 (ISSN-L)
- 1071-5762
- OpenAlex
- W2102917954
- Cited by
- 34
- References
- 44
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 3 · 2020: 4 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 4 · 2015: 2 · 2014: 3 · 2013: 4 · 2012: 2
- FWCI
- 2.99
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Free Radical Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Blood properties and coagulation
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- nitric oxide, red blood cell velocity, erythrocyte deformability, microcirculation, chorioallantoic membrane, NO synthase inhibition, nitric oxide scavenging, vascular tone, capillary blood flow, avian embryo
- MeSH terms
- Animals, Chick Embryo, Chickens, Erythrocytes, Hemodynamics, Nitric Oxide, Ornithine, Nitric Oxide Synthase, Cell Shape, Chorioallantoic Membrane, In Vitro Techniques
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Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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