The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Mechanisms of free radical-induced damage to DNA
Abstract
Endogenous and exogenous sources cause free radical-induced DNA damage in living organisms by a variety of mechanisms. The highly reactive hydroxyl radical reacts with the heterocyclic DNA bases and the sugar moiety near or at diffusion-controlled rates. Hydrated electron and H atom also add to the heterocyclic bases. These reactions lead to adduct radicals, further reactions of which yield numerous products. These include DNA base and sugar products, single- and double-strand breaks, 8,5'-cyclopurine-2'-deoxynucleosides, tandem lesions, clustered sites and DNA-protein cross-links. Reaction conditions and the presence or absence of oxygen profoundly affect the types and yields of the products. There is mounting evidence for an important role of free radical-induced DNA damage in the etiology of numerous diseases including cancer. Further understanding of mechanisms of free radical-induced DNA damage, and cellular repair and biological consequences of DNA damage products will be of outmost importance for disease prevention and treatment.
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Cites
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ROS function in redox signaling and oxidative stress
Schieber, M., & Chandel, N. S. (2014) · Current Biology · doi:10.1016/j.cub.2014.03.034 · Cited by 6,931
Free radicals, natural antioxidants, and their reaction mechanisms
Nimse, S. B., & Pal, D. (2015) · RSC Advances · doi:10.1039/c4ra13315c · Cited by 2,077
Iron and cancer: more ore to be mined
Torti, S. V., & Torti, F. M. (2013) · Nature Reviews Cancer · doi:10.1038/nrc3495 · Cited by 1,621
Baliyan, S., Mukherjee, R., Priyadarshini, A., Vibhuti, A., Gupta, A., Pandey, R. P., & Chang, C.-M. (2022) · Molecules · doi:10.3390/molecules27041326 · Cited by 1,485
Valavanidis, A., Vlachogianni, T., Fiotakis, K., & Loridas, S. (2013) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph10093886 · Cited by 910
Metadata
- Authors
- Dizdaroglu, M., & Jaruga, P.
- Venue
- Free Radical Research
- Publisher
- Informa UK Limited
- Published
- 2012-01-26
- Volume
- 46
- Issue
- 4
- Pages
- 382-419
- ISSN
- 1029-2470 (ISSN-L)
- 1071-5762
- OpenAlex
- W1983598709
- Cited by
- 738
- References
- 13
- FWCI
- 11.85
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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