Factors associated with oxidative stress and cancer risk in the Breast and Prostate Cancer Cohort Consortium
Open accessAbstract
Both endogenous factors (genomic variations) and exogenous factors (environmental exposures, lifestyle) impact the balance of reactive oxygen species (ROS). Variants of the ND3 (rs2853826; G10398A) gene of the mitochondrial genome, manganese superoxide dismutase (MnSOD; rs4880 Val16Ala) and glutathione peroxidase (GPX-1; rs1050450 Pro198Leu), are purported to have functional effects on regulation of ROS balance. In this study, we examined associations of breast and prostate cancer risks and survival with these variants, and interactions between rs4880-rs1050450, and alcohol consumption-rs2853826. Nested case-control studies were conducted in the Breast and Prostate Cancer Cohort Consortium (BPC3), consisting of nine cohorts. The analyses included over 10726 post-menopausal breast and 7532 prostate cancer cases with matched controls. Logistic regression models were used to evaluate associations with risk, and proportional hazard models were used for survival outcomes. We did not observe significant interactions between polymorphisms in MnSOD and GPX-1, or between mitochondrial polymorphisms and alcohol intake and risk of either breast (p-interaction of 0.34 and 0.98, respectively) or prostate cancer (p-interaction of 0.49 and 0.50, respectively). We observed a weak inverse association between prostate cancer risk and GPX-1 Leu198Leu carriers (OR 0.87, 95% CI 0.79-0.97, p = 0.01). Overall survival among women with breast cancer was inversely associated with G10398 carriers who consumed alcohol (HR 0.66 95% CI 0.49-0.88). Given the high power in our study, it is unlikely that interactions tested have more than moderate effects on breast or prostate cancer risk. Observed associations need both further epidemiological and biological confirmation.
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- Authors
- Blein, S., Berndt, S., Joshi, A. D., Campa, D., Ziegler, R. G., Riboli, E., Cox, D. G., on Behalf of the NCI Breast and Prostate Cancer Cohort Consortium, Gaudet, M. M., Stevens, V. L., Diver, W. R., Gapstur, S. M., Chanock, S. J., Hoover, R. N., Yeager, M., Albanes, D., Virtamo, J., Crawford, E. D., Isaacs, C., Berg, C., Trichopoulos, D., Panico, S., Peeters, P. H., Johansson, M., Khaw, K. T., Kraft, P., Hunter, D. J., Lindström, S., Ma, J., Stampfer, M., Gaziano, J. M., Giovannucci, E., Willett, W. H., Hankinson, S. E., Lee, I. M., Buring, J., Henderson, B., Marchand, L. L., Kolonel, L., & Haiman, C. J.
- Affiliations
- Lyon 1 Université (FR)
- National Institutes of Health (US)
- Harvard University (US)
- German Cancer Research Center (DE)
- Université de Lyon (FR)
- Corresponding author
- Cox, D. G.
- ORCID
- Blein, S.
- Berndt, S.
- Joshi, A. D.
- Campa, D.
- Ziegler, R. G.
- Cox, D. G.
- Stevens, V. L.
- Diver, W. R.
- Gapstur, S. M.
- Chanock, S. J.
- Yeager, M.
- Albanes, D.
- Isaacs, C.
- Berg, C.
- Panico, S.
- Peeters, P. H.
- Johansson, M.
- Khaw, K. T.
- Kraft, P.
- Hunter, D. J.
- Lindström, S.
- Ma, J.
- Stampfer, M.
- Giovannucci, E.
- Hankinson, S. E.
- Lee, I. M.
- Buring, J.
- Kolonel, L.
- Haiman, C. J.
- Venue
- Free Radical Research
- Publisher
- Informa UK Limited
- Published
- 2014-01-23
- Volume
- 48
- Issue
- 3
- Pages
- 380-386
- ISSN
- 1029-2470 (ISSN-L)
- 1071-5762
- PMC
- PMC4591275
- OpenAlex
- W2134179485
- Cited by
- 40
- References
- 35
- Citations by year
- 2024: 3 · 2023: 4 · 2022: 4 · 2021: 2 · 2020: 3 · 2019: 1 · 2018: 4 · 2017: 5 · 2016: 6 · 2015: 4 · 2014: 4
- FWCI
- 2.58
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Free Radical Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- CINECA IRIS Institutial research information system (University of Pisa) (submittedVersion)
- Funders
- Cancer Research UK (14136)
- National Institute for Health and Care Research (NF-SI-0512-10114)
- Association Nationale de la Recherche et de la Technologie
- Ligue Contre le Cancer
- National Institutes of Health
- Centers for Disease Control and Prevention
- National Cancer Institute (U01CA098710, U01CA098216, UM1CA164973, U01CA098758, U01CA098233)
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glutathione Transferases and Polymorphisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- oxidative stress, reactive oxygen species, breast cancer, prostate cancer, mitochondrial DNA polymorphism, manganese superoxide dismutase, glutathione peroxidase 1, alcohol consumption, cancer risk, overall survival, postmenopausal women
- MeSH terms
- Breast Neoplasms, Female, Genotype, Humans, Male, Prostatic Neoplasms, Survival Analysis, Reactive Oxygen Species, Oxidative Stress, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide
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