Curcumin-loaded lipid nanocarrier for improving bioavailability, stability and cytotoxicity against malignant glioma cells
Open accessAbstract
OBJECTIVE: In the present study, Curcumin (CU)-loaded nanocarrier (NC) such as nanoemulsion (NE) was developed with the objective of increasing its cytotoxicity and bioavailability through lymphatic transport by enhancing its solubility and intestinal permeability. MATERIALS AND METHODS: Based on the area obtained in pseudoternary phase diagram, various % combination of Labrafac Lipophile WL 1349, Solutol HS 15, Transcutol HP and distilled water were selected. Formulations which passed physical stability studies were selected for further studies such as globule size, zeta potential, in vitro release, ex vivo permeation, in vitro lipolysis studies, bioavailability studies and cytotoxicity against glioblastoma cells (U-87). RESULT AND DISCUSSION: The optimized NC (NE-SB1) had small average globule diameter of 67 ± 6 nm with zeta potential of -37 ± 2.5 mv which indicated long-term dispersion stability. During in vitro lipolysis study, the digestion rate of medium chain triglycerides increased with decreased globule diameter. Statistically significant difference was found in AUC0-inf of NC formulation (p < 0.05) compared to CU suspension. The relative bioavailability of NC was found 11.88 ± 0.47 with respect to CU suspension. During cytotoxicity studies, IC50 of CU solution on U87 cells was found 24.23 µM, while for the NE- SB1 it was 16.41 µM. The optimized formulation was found to be stable during 6 months of accelerated stability. CONCLUSION: The overall results revealed that the CU-loaded NC is a very effective approach for enhancing the oral absorption of poorly water-soluble drug CU and have great potential for future clinical application.
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Nanocarriers and nanotechnology could potentially enhance clinical efficacy and therapeutic response.
“Nonetheless, numerous studies have attempted to improve bioavailability by employing nanocarriers and nanotechnology, which could potentially enhance clinical efficacy and therapeutic response [205].”
From The Multifaceted Role of Neuroprotective Plants in Alzheimer’s Disease Treatment (2022) · cites this paper as [205]
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“Nonetheless, numerous studies have attempted to improve bioavailability by employing nanocarriers and nanotechnology, which could potentially enhance clinical efficacy and therapeutic response [205].”
Background
- Authors
- Kumar, A., Ahuja, A., Ali, J., & Baboota, S.
- Affiliations
- Jamia Hamdard (IN)
- Oman Medical College (OM)
- Corresponding author
- Baboota, Sanjula
- Venue
- Drug Delivery
- Publisher
- Informa UK Limited
- Published
- 2014-05-14
- Volume
- 23
- Issue
- 1
- Pages
- 214-229
- ISSN
- 1071-7544 (ISSN-L)
- 1521-0464
- OpenAlex
- W2061498899
- Cited by
- 76
- References
- 30
- Citations by year
- 2026: 2 · 2025: 8 · 2024: 4 · 2023: 7 · 2022: 10 · 2021: 7 · 2020: 5 · 2019: 13 · 2018: 7 · 2017: 1 · 2016: 8 · 2015: 3 · 2014: 1
- FWCI
- 1.98
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Drug Delivery (publishedVersion)
- PubMed (publishedVersion)
- Funders
- All-India Institute of Medical Sciences
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Curcumin's Biomedical Applications
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
- Keywords
- curcumin, nanoemulsions, bioavailability enhancement, oral bioavailability, glioblastoma, U87 cells, cytotoxicity, lymphatic transport, intestinal permeability, lipolysis, poorly water-soluble drugs, drug stability
- MeSH terms
- Animals, Antineoplastic Agents, Phytogenic, Biological Availability, Brain Neoplasms, Chemistry, Pharmaceutical, Curcumin, Drug Carriers, Drug Stability, Glioblastoma, Humans, Intestinal Absorption, Lipolysis, Particle Size, Triglycerides, Rats, Wistar, Cell Line, Tumor, Rats, Nanoparticles
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