Formulations of Curcumin Nanoparticles for Brain Diseases

Del Prado-Audelo, María L.; Caballero-Florán, Isaac H.; Meza-Toledo, Jorge A.; Mendoza-Muñoz, Néstor; González-Torres, Maykel; Florán, Benjamín; Cortés, Hernán; Leyva-Gómez, Gerardo

doi:10.3390/biom9020056

Cited by 191Curcumin's Biomedical ApplicationsDrug Solubulity and Delivery SystemsAdvanced Drug Delivery Systems

Formulations of Curcumin Nanoparticles for Brain Diseases

Open access

Del Prado-Audelo, María L., Caballero-Florán, Isaac H., Meza-Toledo, Jorge A., Mendoza-Muñoz, Néstor, González-Torres, Maykel, Florán, Benjamín, Cortés, Hernán, Leyva-Gómez, Gerardo·2019·Biomolecules

DOI 10.3390/biom9020056PMC PMC6406762

Open this paper in CoChat — free account Open PDF

Abstract

Curcumin is a polyphenol that is obtained from Curcuma longa and used in various areas, such as food and textiles. Curcumin has important anti-inflammatory and antioxidant properties that allow it to be applied as treatment for several emerging pathologies. Remarkably, there are an elevated number of publications deriving from the terms “curcumin” and “curcumin brain diseases”, which highlights the increasing impact of this polyphenol and the high number of study groups investigating their therapeutic actions. However, its lack of solubility in aqueous media, as well as its poor bioavailability in biological systems, represent limiting factors for its successful application. In this review article, the analysis of its chemical composition and the pivotal mechanisms for brain applications are addressed in a global manner. Furthermore, we emphasize the use of nanoparticles with curcumin and the benefits that have been reached as an example of the extensive advances in this area of health.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.3390/biom9020056

Cites

129 of 129 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Sophisticated surface modification of nanoparticles allows adequate transit to the brain.
“Mainly due to a sophisticated surface modification of the nanoparticle that allows adequate transit to the brain [215,216].”
From Multi-Target Mechanisms of Phytochemicals in Alzheimer’s Disease: Effects on Oxidative Stress, Neuroinflammation and Protein Aggregation (2022) · cites this paper as [216]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Doxil® — The first FDA-approved nano-drug: Lessons learned
Barenholz, Y. (. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2012.03.020 · Cited by 4,792 · cited 1× · see citing works
“, Doxil (Janssen, Titusville, FL, USA) for the treatment of certain types of cancer [83].”
Curcumin Inhibits Formation of Amyloid β Oligomers and Fibrils, Binds Plaques, and Reduces Amyloid in Vivo
Yang, F., Lim, G. P., Begum, A. N., Ubeda, O. J., Simmons, M. R., Ambegaokar, S. S., Chen, P. P., Kayed, R., Glabe, C. G., Frautschy, S. A., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m404751200 · Cited by 2,336 · cited 1× · see citing works
“A more detailed report on the inhibition of Aβ aggregation revealed that, besides curcumin inhibiting fibril formation in vitro, it also inhibited the formation of Aβ oligomers and their toxicity in vivo [37].”
Background
Tau-mediated neurodegeneration in Alzheimer’s disease and related disorders
Ballatore, C., Lee, V. M.-Y., & Trojanowski, J. Q. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2194 · Cited by 2,174 · cited 1× · see citing works
“Its main clinical features are memory loss, behavioral changes, and cognitive impairment [126,127].”
Background
Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases
Aggarwal, B. B., & Harikumar, K. B. (2008) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2008.06.010 · Cited by 2,043 · cited 1× · see citing works
“It has been shown that curcumin possess anti-inflammatory and antioxidant properties [1,2].”
Background
Curcumin: the Indian solid gold.
Aggarwal, B., Sundaram, C., Malani, N., & Ichikawa, H. (2007) · Advances in Experimental Medicine and Biology · doi:10.1007/978-0-387-46401-5_1 · Cited by 1,742 · cited 1× · see citing works
“It has been shown to decompose when it is exposed to UV/visible light, both in solution and in the solid state [26].”
Background
Stability of curcumin in buffer solutions and characterization of its degradation products
Wang, Y., Pan, M., Cheng, A., Lin, L., Ho, Y., Hsieh, C., & Lin, J. (1997) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/s0731-7085(96)02024-9 · Cited by 1,709 · cited 2× · see citing works
“2–6) than in alkaline pH (Figure 3); the degradation products found under hydrolytic conditions are: trans-6-(4′-hydroxy-3′-methoxyphenyl)-2,4-dioxo-5-hexenal, ferulic acid, ferulic aldehyde, feruloylmethane, and vanillin [22,23].”
Background
Neuroinflammation: The Devil Is in the Details
DiSabato, D. J., Quan, N., & Godbout, J. P. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13607 · Cited by 1,640 · cited 1× · see citing works
“Interleukins such as IL-1β, IL-6, and IL-23, and cytokines such as TNF, interferon gamma (IFNγ), and granulocyte/macrophage colony-stimulating factor (GM-CSF), chemokines (such as CCL2, CCL5, and CXCL1), secondary messengers (nitric oxide and prostaglandins), and ROS are also mediators for the neuroinflammatory respon…”
Background
The Chemistry of Curcumin: From Extraction to Therapeutic Agent
Priyadarsini, K. I. (2014) · Molecules · doi:10.3390/molecules191220091 · Cited by 1,520 · cited 9× · see citing works
“From a structural point of view, there are three chemical entities in the molecule: two aromatic ring systems containing o-methoxy phenolic groups linked by a seven-carbon spacer consisting of an α,β-unsaturated β-diketone moiety [11].”
BackgroundMethodResultInfluential
Activation of Transcription Factor NF-κB Is Suppressed by Curcumin (Diferuloylmethane)
Singh, S., & Aggarwal, B. B. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.42.24995 · Cited by 1,386 · cited 1× · see citing works
“These authors reported that curcumin reduced the transcription and secretion of TNF-α, and also IL-6, which is induced by palmitate, and induces the nuclear translocation of NF-κB in a concentration-dependent manner [48,49].”
Phase I Clinical Trial of Oral Curcumin
Sharma, R. A., Euden, S. A., Platton, S. L., Cooke, D. N., Shafayat, A., Hewitt, H. R., Marczylo, T. H., Morgan, B., Hemingway, D., Plummer, S. M., et al. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-0744 · Cited by 1,260 · cited 1× · see citing works
“1 nmol/L after one hour of dosing on days one, two, eight, and 29 of the administration [65].”
Background
Alzheimer's disease: strategies for disease modification
Citron, M. (2010) · Nature Reviews Drug Discovery · doi:10.1038/nrd2896 · Cited by 1,060 · cited 1× · see citing works
“Its main clinical features are memory loss, behavioral changes, and cognitive impairment [126,127].”
Background
Cyclodextrins: structure, physicochemical properties and pharmaceutical applications
Jansook, P., Ogawa, N., & Loftsson, Þ. (2017) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2017.11.018 · Cited by 824 · cited 1× · see citing works
“Cyclodextrins are glucopyranose structures in the form of a glass with a hydrophobic interior and a hydrophilic exterior by the exposure of hydroxyl units [84].”
Background
Curcumin nanoformulations: a future nanomedicine for cancer
Yallapu, M. M., Jaggi, M., & Chauhan, S. C. (2011) · Drug Discovery Today · doi:10.1016/j.drudis.2011.09.009 · Cited by 780 · cited 1× · see citing works
“This is because they can be designed and adapted to the desired size, chemical composition, surface charge, and surface functionalization, rendering them potent tools for the treatment of specific diseases such as neurodegenerative disorders and cancer [75,76].”
Background
Protein aggregation diseases: pathogenicity and therapeutic perspectives
Aguzzi, A., & O’Connor, T. (2010) · Nature Reviews Drug Discovery · doi:10.1038/nrd3050 · Cited by 750 · cited 2× · see citing works
“These neuronal diseases include disorders in which the aggregates may accumulate in the nucleus, such as for example in polyglutamine expansion diseases (such as spinocerebellar ataxias and Huntington’s disease (HD)), which are pathologies that are characterized by inclusions in cytoplasm (for example, α-synuclein in…”
Background
The Targets of Curcumin
Zhou, H., Beevers, C. S., & Huang, S. (2011) · Current Drug Targets · doi:10.2174/138945011794815356 · Cited by 715 · cited 2× · see citing works
“During angioge esis, curcumi can inhibit and/or downregulate the expression of various pro- ngiogenic growth factors suc as the vascula endothelial grow h factor (VEGF), fibroblas growth factor (FGF), and the endothelial gr wth fact r (EGF) [30].”
Background
Physical and Chemical Stability of Curcumin in Aqueous Solutions and Emulsions: Impact of pH, Temperature, and Molecular Environment
Kharat, M., Du, Z., Zhang, G., & McClements, D. J. (2016) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.6b04815 · Cited by 694 · cited 2× · see citing works
“[16] mentioned the formation of condensation yellow products (such as feruloymethane) as a potential reason for this color increment under an alkaline environment.”
Background
Cytokine networks in neuroinflammation
Becher, B., Spath, S., & Goverman, J. M. (2016) · Nature reviews. Immunology · doi:10.1038/nri.2016.123 · Cited by 681 · cited 4× · see citing works
“parenchyma by leukocytes, it is one of its main characteristics, as well as a severe loss of the blood– brain barrier (BBB) integrity [6].”
BackgroundInfluential
Curcumin-Loaded Nanoparticles Potently Induce Adult Neurogenesis and Reverse Cognitive Deficits in Alzheimer’s Disease Model <i>via</i> Canonical Wnt/β-Catenin Pathway
Tiwari, S. K., Agarwal, S., Seth, B., Yadav, A., Nair, S., Bhatnagar, P., Karmakar, M., Kumari, M., Chauhan, L. K. S., Patel, D. K., et al. (2014) · ACS Nano · doi:10.1021/nn405077y · Cited by 558 · cited 2× · see citing works
“[105] explored the effect of PLGA nanoparticles loaded with curcumin (PLGA–NP–Cur) on neuronal differentiation and NSC proliferation.”
Background
Antioxidant and structure–activity relationships (SARs) of some phenolic and anilines compounds
Bendary, E., Francis, R. R., Ali, H. M. G., Sarwat, M. I., & El Hady, S. (2013) · Annals of Agricultural Sciences · doi:10.1016/j.aoas.2013.07.002 · Cited by 555 · cited 2× · see citing works
“In addition to BDE and IP, proton dissociation enthalpy, proton affinity (PA), and electron transfer enthalpy are important factors for evaluating antioxidant activity [55,57].”
Background
Nanoparticles—a historical perspective
Kreuter, J. (2006) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2006.10.021 · Cited by 540 · cited 1× · see citing works
“Conventionally, nanoparticles for medical purposes arise from the combination of two master ideas: from Paul Ehrlich with the concept of magical bullets [77], and Richard Feynman with the notion of miniaturization [78].”
Background
Passage of peptides through the blood-brain barrier with colloidal polymer particles (nanoparticles)
Kreuter, J., Alyautdin, R. N., Kharkevich, D. A., & Aa, I. (1995) · Brain Research · doi:10.1016/0006-8993(95)00023-j · Cited by 538 · cited 1× · see citing works
“[80] began the initial assessments on the coating of nanoparticles with polysorbate 80 to facilitate their passage into the CNS.”
Background
Curcumin and its nano-formulation: The kinetics of tissue distribution and blood–brain barrier penetration
Tsai, Y.-M., Chien, C.-F., Lin, L.-C., & Tsai, T. (2011) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2011.06.030 · Cited by 535 · see citing works
Neuroprotective effects of curcumin
Cole, G. M., Teter, B., & Frautschy, S. A. (2007) · ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY · doi:10.1007/978-0-387-46401-5_8 · Cited by 516 · see citing works
The molecular targets and therapeutic uses of curcumin in health and disease
Aggarwal, B., Surh, Y., & Shishodia, S. (2007) · Advances in experimental medicine and biology · doi:10.1007/978-0-387-46401-5 · Cited by 505 · see citing works
Nanoparticles Types, Classification, Characterization, Fabrication Methods and Drug Delivery Applications
Bhatia, S. (2016) · Springer eBooks · doi:10.1007/978-3-319-41129-3_2 · Cited by 498 · see citing works
Neuroprotective properties of the natural phenolic antioxidants curcumin and naringenin but not quercetin and fisetin in a 6-OHDA model of Parkinson's disease
Zbarsky, V., Datla, K. P., Parkar, S., Rai, D. K., Aruoma, O. I., & Dexter, D. T. (2005) · Free Radical Research · doi:10.1080/10715760500233113 · Cited by 462 · cited 2× · see citing works
“[58] applied, in the unilateral 6-hydroxydopamine (6-OHDA) rat model of PD, natural compounds, with phenolic groups in their structure to evaluate the neuroprotection level.”
Background
Degradation of Curcumin: From Mechanism to Biological Implications
Schneider, C. G., Gordon, O. N., Edwards, R. L., & Luis, P. B. (2015) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5b00244 · Cited by 445 · cited 2× · see citing works
“However, new evidence suggests that the major degradation product is bicyclopentadione, which is the result of the autoxidation of curcumin [24], and is formed by the oxygenation and double cyclization of the heptadienedione chain connecting the two methoxyphenol rings of curcumin [25].”
Background
Polymer degradation and drug delivery in PLGA ‐based drug–polymer applications: A review of experiments and theories
Xu, Y., Kim, C. S., Saylor, D. M., & Koo, D. (2016) · Journal of Biomedical Materials Research Part B Applied Biomaterials · doi:10.1002/jbm.b.33648 · Cited by 434 · cited 2× · see citing works
“However, other studies have indicated that the degradation of PLGA could induce cellular damage by the generated acidic medium, although this is restricted to the amount of polymer that was administered [82].”
Background
Curcumin: an orally bioavailable blocker of TNF and other pro‐inflammatory biomarkers
Aggarwal, B. B., Gupta, S. C., & Sung, B. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12131 · Cited by 401 · cited 1× · see citing works
“These authors reported that curcumin reduced the transcription and secretion of TNF-α, and also IL-6, which is induced by palmitate, and induces the nuclear translocation of NF-κB in a concentration-dependent manner [48,49].”
Background
Curcumin Loaded-PLGA Nanoparticles Conjugated with Tet-1 Peptide for Potential Use in Alzheimer's Disease
Mathew, A., Fukuda, T., Nagaoka, Y., Hasumura, T., Morimoto, H., Yoshida, Y., Maekawa, T., Venugopal, K., & Kumar, D. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032616 · Cited by 399 · cited 1× · see citing works
“PLGA Tet-1 150-200, Ψ = −30 to −20 Amyloid aggregates (in vitro model) [107]”
Background
Enhancement of oral absorption of curcumin by self-microemulsifying drug delivery systems
Cui, J., Yu, B., Zhao, Y., Zhu, W., Li, H., Lou, H., & Zhai, G. (2008) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2008.12.009 · Cited by 396 · see citing works
NMR Study of the Solution Structure of Curcumin
Payton, F., Sandusky, P. O., & Alworth, W. L. (2007) · Journal of Natural Products · doi:10.1021/np060263s · Cited by 381 · cited 1× · see citing works
“However, nuclear magnetic resonance (NMR) studies carried out on a variety of solvents concluded that the enol form of curcumin is essentially the only form of this molecule in solution [12].”
Background
BACE1: The β-Secretase Enzyme in Alzheimer's Disease
Vassar, R. J. (2004) · Journal of Molecular Neuroscience · doi:10.1385/jmn:23:1-2:105 · Cited by 369 · see citing works
Intracellular ROS Protection Efficiency and Free Radical-Scavenging Activity of Curcumin
Barzegar, A., & Moosavi‐Movahedi, A. A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026012 · Cited by 369 · cited 2× · see citing works
“[60] analyzed the antioxidant properties of curcumin.”
Background
The Metabolism and Excretion of Curcumin (1,7-Bis-(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione) in the Rat
Holder, G. M., Plummer, J. L., & Ryan, A. J. (1978) · Xenobiotica · doi:10.3109/00498257809069589 · Cited by 361 · cited 1× · see citing works
“In fact, the majority of oral curcumin is excreted in the feces—about 90%—and the rest in urine (6%) after 72 hours in rats [64].”
Background
Curcumin, An Atoxic Antioxidant and Natural NFκB, Cyclooxygenase‐2, Lipooxygenase, and Inducible Nitric Oxide Synthase Inhibitor: A Shield Against Acute and Chronic Diseases
Bengmark, S. (2006) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/014860710603000145 · Cited by 345 · see citing works
Self-microemulsifying drug delivery system (SMEDDS) – challenges and road ahead
Dokania, S., & Joshi, A. (2014) · Drug Delivery · doi:10.3109/10717544.2014.896058 · Cited by 337 · cited 1× · see citing works
“Self-microemulsifying drug delivery systems (SMEDDS) are isotropic mixtures of oil, hydrophilic surfactant, and co-solvents that rapidly form oil-in-water (o/w) microemulsion upon gentle agitation followed by dilution in an aqueous medium [70].”
Background
Structure–activity Relationships of Amyloid Beta‐aggregation Inhibitors Based on Curcumin: Influence of Linker Length and Flexibility
Reinke, A. A., & Gestwicki, J. E. (2007) · Chemical Biology & Drug Design · doi:10.1111/j.1747-0285.2007.00557.x · Cited by 330 · cited 3× · see citing works
“Finally, the diketo chain contributes to the flexibility and correct length between aromatic rings [27].”
BackgroundInfluential
Preparation of Curcumin-Loaded Liposomes and Evaluation of Their Skin Permeation and Pharmacodynamics
Chen, Y., Wu, Q., Zhang, Z., Yuan, L., Liu, X., & Zhou, L. (2012) · Molecules · doi:10.3390/molecules17055972 · Cited by 316 · cited 2× · see citing works
“05 °C, which is in agreement with data reported previously [14].”
Result
Highly Stabilized Curcumin Nanoparticles Tested in an In Vitro Blood–Brain Barrier Model and in Alzheimer’s Disease Tg2576 Mice
Cheng, K. K., Yeung, C. F., Ho, S. W., Chow, S. F., Chow, A. H. L., & Baum, L. (2012) · The AAPS Journal · doi:10.1208/s12248-012-9444-4 · Cited by 315 · cited 1× · see citing works
“29 EE = 99 Alzheimer’s Disease Tg2576 Mice (in vitro and in vivo models) [113]”
Background
Nanotechnology-based drug delivery systems for the treatment of Alzheimer’s disease
Fonseca‐Santos, B., Chorilli, M., & Gremião, M. P. D. (2015) · International Journal of Nanomedicine · doi:10.2147/ijn.s87148 · Cited by 313 · see citing works
The pharmacology of curcumin: is it the degradation products?
Shen, L., & Ji, H. (2012) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2012.01.004 · Cited by 296 · cited 8× · see citing works
“In AD, curcumin protects against Aβ-induced oxidative stress, prevents the formation and extension of Aβ fibrils, destabilizes Aβ fibrils, inhibits acetylcholinesterase, decreases neuroinflammation, and sequesters transition metals [22].”
BackgroundInfluential
Curcumin downregulates human tumor necrosis factor-α levels: A systematic review and meta-analysis ofrandomized controlled trials
Sahebkar, A., Cicero, A. F. G., Simental‐Mendía, L. E., Aggarwal, B. B., & Gupta, S. C. (2016) · Pharmacological Research · doi:10.1016/j.phrs.2016.03.026 · Cited by 295 · cited 1× · see citing works
“On the other hand, TNF-α is a very important inflammatory mediator; thus, its reduction is a therapeutic target in several inflammatory diseases [47].”
Background
Curcumin-conjugated magnetic nanoparticles for detecting amyloid plaques in Alzheimer's disease mice using magnetic resonance imaging (MRI)
Cheng, K. K., Chan, P. S., Fan, S., Kwan, S. M., Yeung, K. L., Wáng, Y. X. J., Chow, A. H. L., Wu, E. X., & Baum, L. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2014.12.005 · Cited by 293 · cited 1× · see citing works
“01 EE = 99 Detection of amyloid plaques in Alzheimer’s (in vitro and in vivo models) [120]”
Background
Curcumin inhibits aggregation of α-synuclein
Pandey, N., Strider, J., Nolan, W. C., Yan, S. X., & Galvin, J. E. (2008) · Acta Neuropathologica · doi:10.1007/s00401-007-0332-4 · Cited by 265 · cited 1× · see citing works
“[34] analyzed the curcumin effect both in vitro and in cell culture models of α-synuclein aggregation.”
Background
Curcumin-loaded PLGA-PEG nanoparticles conjugated with B6 peptide for potential use in Alzheimer’s disease
Fan, S., Zheng, Y., Liu, X., Fang, W., Chen, X., Liao, W., Jing, X., Lei, M., Tao, E., Ma, Q., et al. (2018) · Drug Delivery · doi:10.1080/10717544.2018.1461955 · Cited by 263 · cited 2× · see citing works
“Finally, in a recent report, PLGA–PEG nanoparticles attached to the B6 peptide with curcumin encapsulated (PLGA/PEG-B6-Cur) were designed [108].”
Background
Identification of permeability-related hurdles in oral delivery of curcumin using the Caco-2 cell model
Wahlang, B., Pawar, Y. B., & Bansal, A. K. (2010) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2010.12.006 · Cited by 260 · cited 1× · see citing works
“There are two main limitations when curcumin is formulated for therapeutic purposes: limited solubility in water and low permeability [63].”
Background
Dual-Targeting Magnetic PLGA Nanoparticles for Codelivery of Paclitaxel and Curcumin for Brain Tumor Therapy
Cui, Y., Zhang, M., Zeng, F., Jin, H., Xu, Q., & Huang, Y. (2016) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b10175 · Cited by 243 · cited 1× · see citing works
“9 EE = 18 Brain tumor (in vitro and in vivo models) [110]”
Background
Trace metal contamination initiates the apparent auto-aggregation, amyloidosis, and oligomerization of Alzheimer?s A? peptides
Huang, X., Atwood, C., Moir, R. D., Hartshorn, M. A., Tanzi, R. E., & Bush, A. I. (2004) · JBIC Journal of Biological Inorganic Chemistry · doi:10.1007/s00775-004-0602-8 · Cited by 241 · cited 1× · see citing works
“It has been reported that amyloid formation could be limited by mechanisms such as metal chelation [38], and reducing the induction of the β-secretase enzyme (BACE1) by proinflammatory cytokines [39].”
Background
Curcumin-loaded nanostructured lipid carriers (NLCs) for nasal administration: design, characterization, and in vivo study
Madane, R. G., & Mahajan, H. S. (2014) · Drug Delivery · doi:10.3109/10717544.2014.975382 · Cited by 241 · cited 1× · see citing works
“86 Astrocytoma-glioblastoma (in vitro and in vivo models) [92]”
Background
Advances in Nanotechnology-Based Delivery Systems for Curcumin
Sun, M. H., Su, X. J., Ding, B., He, X., Liu, X., Yu, A., Lou, H., & Zhai, G. (2012) · Nanomedicine · doi:10.2217/nnm.12.80 · Cited by 240 · cited 1× · see citing works
“This is because they can be designed and adapted to the desired size, chemical composition, surface charge, and surface functionalization, rendering them potent tools for the treatment of specific diseases such as neurodegenerative disorders and cancer [75,76].”
Background
Use of Curcumin, a Natural Polyphenol for Targeting Molecular Pathways in Treating Age-Related Neurodegenerative Diseases
Maiti, P., & Dunbar, G. L. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19061637 · Cited by 236 · cited 2× · see citing works
“On the other hand, under basic conditions (p > 8), the enol confor ation is predo inant, hich presents po erful free radical-scavenger properties [59].”
Background
“There is plenty of room at the Bottom”.
Leson, A. (2005) · Vakuum in Forschung und Praxis · doi:10.1002/vipr.200590035 · Cited by 232 · cited 1× · see citing works
“Conventionally, nanoparticles for medical purposes arise from the combination of two master ideas: from Paul Ehrlich with the concept of magical bullets [77], and Richard Feynman with the notion of miniaturization [78].”
Background
Curcumin loaded solid lipid nanoparticles: an efficient formulation approach for cerebral ischemic reperfusion injury in rats.
Kakkar, V., Muppu, S. K., Chopra, K., & Kaur, I. P. (2013) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2013.02.005 · Cited by 222 · cited 1× · see citing works
“3 Cerebral ischemic injury (in vivo model) [86]”
Background
Phagocytic Uptake and Cytotoxicity of Solid Lipid Nanoparticles (SLN) Sterically Stabilized with Poloxamine 908 and Poloxamer 407
Müller, R., Maaben, S., Weyhers, H., & Mehnert, W. (1996) · Journal of drug targeting · doi:10.3109/10611869609015973 · Cited by 222 · cited 1× · see citing works
“[81] worked on the development of lipid nanoparticles that would later allow for wide applications in the same area.”
Background
Molecular targets of curcumin for cancer therapy: an updated review
Kasi, P. D., Rajavel, T., Skalicka‐Woźniak, K., Nabavi, S. F., Daglia, M., Bishayee, A., Pazoki–Toroudi, H., & Nabavi, S. M. (2016) · Tumor Biology · doi:10.1007/s13277-016-5183-y · Cited by 216 · cited 2× · see citing works
“The spe ific molecul targets fo curcumin that are therapeutically important in cancer-si naling pathways include cyclin-dependent kinases (CDKs), p53, Ras, phosphoinositide 3-kinase (PI3K), Protein inase B (Ak ), Wnt/β-catenin, and mammalian target of rapamycin (mTOR) [29].”
Background
Evaluating potential of curcumin loaded solid lipid nanoparticles in aluminium induced behavioural, biochemical and histopathological alterations in mice brain
Kakkar, V., & Kaur, I. P. (2011) · Food and Chemical Toxicology · doi:10.1016/j.fct.2011.08.006 · Cited by 212 · cited 1× · see citing works
“3 Aluminum-induced behavioral (in vivo model) [90]”
Curcumin Suppresses IL-1β Secretion and Prevents Inflammation through Inhibition of the NLRP3 Inflammasome
Yin, H., Guo, Q., Li, X., Tang, T., Li, C., Wang, H., Sun, Y., Feng, Q., Ma, C., Gao, C., et al. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1701495 · Cited by 210 · cited 6× · see citing works
“Some authors have reported that curcumin suppresses the expression of IL-1β [44,45].”
BackgroundInfluential
Development of an optimized hyaluronic acid-based lipidic nanoemulsion co-encapsulating two polyphenols for nose to brain delivery
Nasr, M. (2016) · Drug Delivery · doi:10.3109/10717544.2015.1092619 · Cited by 208 · cited 1× · see citing works
“8 Biodistribution (ex vivo and in vivo models) [117]”
Background
Enhanced Oral Delivery of Curcumin from N-trimethyl Chitosan Surface-Modified Solid Lipid Nanoparticles: Pharmacokinetic and Brain Distribution Evaluations
Ramalingam, P., & Ko, Y. T. (2014) · Pharmaceutical Research · doi:10.1007/s11095-014-1469-1 · Cited by 206 · cited 1× · see citing works
“7 93, 4 Biodistribution (in vitro and in vivo models) [89]”
Background
Curcumin nanoparticles attenuate neurochemical and neurobehavioral deficits in experimental model of huntington’s disease.
Sandhir, R., Yadav, A., Mehrotra, A., Sunkaria, A., Singh, A., & Sharma, S. (2014) · NeuroMolecular Medicine · doi:10.1007/s12017-013-8261-y · Cited by 204 · cited 2× · see citing works
“[87] fabricated solid lipid nanoparticles loaded with curcumin (SLNP-Cur) and explored their neuroprotective effectiveness in a HD rat model induced by 3-nitropropionic acid (3-NP).”
Background
Brain Delivery of Curcumin Using Solid Lipid Nanoparticles and Nanostructured Lipid Carriers: Preparation, Optimization, and Pharmacokinetic Evaluation
Malvajerd, S. S., Azadi, A., Izadi, Z., Kurd, M., Dara, T., Dibaei, M., Zadeh, M. S., Javar, H. A., & Hamidi, M. (2018) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.8b00510 · Cited by 203 · cited 2× · see citing works
“It has been suggested that aluminum is involved in the etiology of AD; thus, in an early study, the neuroprotective effect of solid lipid nanoparticles loaded with curcumin (SLN-Cur) was proved in an AD mouse model induced by 100 mg/kg of aluminum chloride [91].”
Curcumin Decreases Amyloid-β Peptide Levels by Attenuating the Maturation of Amyloid-β Precursor Protein
Zhang, C. M., Browne, A., Child, D. D., & Tanzi, R. E. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.133520 · Cited by 190 · cited 3× · see citing works
“Furthermore, it h s been recently de onstrated that curcumin may inhibit protein aggregation, such as amyloid-β (Aβ) protein, which is related to sever l neurological pathologies, such as Alzheimer’s disease (AD) [7].”
BackgroundInfluential
Curcumin Pretreatment Induces Nrf2 and an Antioxidant Response and Prevents Hemin-Induced Toxicity in Primary Cultures of Cerebellar Granule Neurons of Rats
González-Reyes, S., Guzmán‐Beltrán, S., Medina‐Campos, O. N., & Pedraza‐Chaverrí, J. (2013) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2013/801418 · Cited by 180 · cited 1× · see citing works
“[61] evaluated the neuroprotection of curcumin in the primary cultures of the cerebellar granule neurons of rats.”
Background
Localized delivery of curcumin into brain with polysorbate 80-modified cerasomes by ultrasound-targeted microbubble destruction for improved Parkinson's disease therapy
Zhang, N., Yan, F., Liang, X., Wu, M., Shen, Y., Chen, M., Xu, Y., Zou, G., Jiang, P., Tang, C., et al. (2018) · Theranostics · doi:10.7150/thno.23734 · Cited by 180 · cited 1× · see citing works
“[133] developed curcumin-loaded polysorbate 80-modified cerasomes (PS80-NP-Cur).”
Novel Curcumin loaded nanoparticles engineered for Blood-Brain Barrier crossing and able to disrupt Abeta aggregates
Ruozi, B., Belletti, D., Pederzoli, F., Masoni, M., Keller, J., Ballestrazzi, A., Vandelli, M. A., Tosi, G., & Grabrucker, A. M. (2017) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2017.05.015 · Cited by 178 · cited 1× · see citing works
“[129] designed and engineered a curcumin-encapsulated PLGA nanoparticle bound to peptide g7 (Cur-NP-g7) to promote BBB crossing.”
A novel LDL-mimic nanocarrier for the targeted delivery of curcumin into the brain to treat Alzheimer's disease
Meng, F., Asghar, S., Gao, S., Su, Z., Song, J., Huo, M., Meng, W., Ping, Q., & Xiao, Y. (2015) · Colloids and Surfaces B: Biointerfaces · doi:10.1016/j.colsurfb.2015.06.025 · Cited by 176 · cited 4× · see citing works
“60 Alzheimer ́s disease (in vitro and in vivo models) [94]”
BackgroundInfluential
Structure-Thermodynamics-Antioxidant Activity Relationships of Selected Natural Phenolic Acids and Derivatives: An Experimental and Theoretical Evaluation
Chen, Y., Xiao, H., Zheng, J., & Liang, G. (2015) · PLoS ONE · doi:10.1371/journal.pone.0121276 · Cited by 172 · cited 1× · see citing works
“In addition to BDE and IP, proton dissociation enthalpy, proton affinity (PA), and electron transfer enthalpy are important factors for evaluating antioxidant activity [55,57].”
Background
PLGA nanoparticles modified with a BBB-penetrating peptide co-delivering Aβ generation inhibitor and curcumin attenuate memory deficits and neuropathology in Alzheimer's disease mice
Huang, N., Lü, S., Liu, X., Zhu, J., Wang, Y., & Liu, R. (2017) · Oncotarget · doi:10.18632/oncotarget.20944 · Cited by 170 · cited 1× · see citing works
“[130], PLGA nanoparticles were designed conjugated with the S1 peptide (an inhibitor of Aβ generation), brain-targeting calreticulin (CRT) (a peptide that binds to the transferrin receptor), and curcumin (as a therapeutic substance to tackle the disorder).”
Background
Enhanced Therapeutic Potential of Nano-Curcumin Against Subarachnoid Hemorrhage-Induced Blood–Brain Barrier Disruption Through Inhibition of Inflammatory Response and Oxidative Stress
Zhang, Z., Jiang, M., Fang, J., Yang, M., Zhang, S., Yin, Y., Li, D., Mao, L., Fu, X., Hou, Y., et al. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9635-y · Cited by 165 · cited 1× · see citing works
“3 Subarachnoid hemorrhage-induced BBB disruption (in vivo model) [112]”
Background
Delivery of Dual Drug Loaded Lipid Based Nanoparticles across the Blood–Brain Barrier Impart Enhanced Neuroprotection in a Rotenone Induced Mouse Model of Parkinson’s Disease
Kundu, P., Das, M., Tripathy, K., & Sahoo, S. K. (2016) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.6b00207 · Cited by 164 · cited 2× · see citing works
“[88] designed glyceryl monooleate nanoparticles loaded with piperine and curcumin (GMO-NP-Pip/Cur).”
Background
Curcumin, a Potential Inhibitor of Up-regulation of TNF-alpha and IL-6 Induced by Palmitate in 3T3-L1 Adipocytes through NF-kappaB and JNK Pathway
Shao-Ling, W. A. N. G., Ying, L. I., Wen, Y., Yan-Feng, C. H. E. N., Na, L.-X., Li, S., & Sun, C. (2009) · Biomedical and Environmental Sciences · doi:10.1016/s0895-3988(09)60019-2 · Cited by 157 · cited 1× · see citing works
“[4] found inhibition in the expression of this factor through downregulating the expression of NF-κB.”
Autoxidative and Cyclooxygenase-2 Catalyzed Transformation of the Dietary Chemopreventive Agent Curcumin
Grießer, M., Pistis, V., Suzuki, T., Tejera, N., Pratt, D. A., & Schneider, C. G. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.178806 · Cited by 154 · cited 2× · see citing works
“However, new evidence suggests that the major degradation product is bicyclopentadione, which is the result of the autoxidation of curcumin [24], and is formed by the oxygenation and double cyclization of the heptadienedione chain connecting the two methoxyphenol rings of curcumin [25].”
Background
Curcumin encapsulated in chitosan nanoparticles: A novel strategy for the treatment of arsenic toxicity
Yadav, A., Lomash, V., Samim, M., & Flora, S. J. S. (2012) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2012.05.011 · Cited by 154 · cited 1× · see citing works
“8 Arsenic toxicity (in vivo model) [102]”
Neuroinflammation in Alzheimer's disease: different molecular targets and potential therapeutic agents including curcumin
Ray, B., & Lahiri, D. K. (2009) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2009.06.012 · Cited by 152 · cited 3× · see citing works
“Other molecular targets inhibited by curcumin are inducible nitric oxide synthase (iNOs), c-Jun N-terminal kinase (JNK) activation, and activating protein-1 (AP-1) [28].”
BackgroundInfluential
Relationship between the tautomeric structures of curcumin derivatives and their Aβ-binding activities in the context of therapies for Alzheimer's disease
Yanagisawa, D., Shirai, N., Amatsubo, T., Taguchi, H., Hirao, K., Urushitani, M., Morikawa, S., Inubushi, T., Kato, M. G., Kato, F., et al. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.01.142 · Cited by 151 · cited 1× · see citing works
“[13]; these authors suggested that curcumin and its analogues exist predominantly in the enol form during binding to Aβ fibrils/aggregates, in turn suggesting that the enolization of curcumin derivatives is crucial for binding to Aβ aggregates in the treatment of AD.”
Background
Curcumin-conjugated Nanoliposomes with High Affinity for Aβ Deposits: Possible Applications to Alzheimer Disease
Lazar, A. N., Mourtas, S., Youssef, I., Parizot, C., Dauphin, A., Delatour, B., Antimisiaris, S. G., & Duyckaerts, C. (2013) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2012.11.004 · Cited by 149 · cited 1× · see citing works
“5 Amyloid peptide plaques (in vivo model) [124]”
Background
ApoE3 Mediated Poly(butyl) Cyanoacrylate Nanoparticles Containing Curcumin: Study of Enhanced Activity of Curcumin against Beta Amyloid Induced Cytotoxicity Using In Vitro Cell Culture Model
Mulik, R. S., Mönkkönen, J., Juvonen, R. O., Mahadik, K. R., & Paradkar, A. R. (2010) · Molecular Pharmaceutics · doi:10.1021/mp900306x · Cited by 147 · cited 1× · see citing works
“44 Beta amyloid induced cytotoxicity in neuroblastoma cells (in vitro model) [97]”
Dendrosomal curcumin nanoformulation downregulates pluripotency genes via miR-145 activation in U87MG glioblastoma cells
Sadeghizadeh, M., Birgani, M. T., Isacchi, Marra, F., Bilia, A. R., Mowla, S. J., Najafi, F., & Babaei, E. (2014) · International Journal of Nanomedicine · doi:10.2147/ijn.s48136 · Cited by 137 · cited 1× · see citing works
“4, Ψ = −7 EE = 87 Glioblastoma cells (in vitro model) [115]”
Self-microemulsifying drug delivery system improves curcumin dissolution and bioavailability
Wu, X., Xu, J., Huang, X., & Wen, C. (2010) · Drug Development and Industrial Pharmacy · doi:10.3109/03639045.2010.489560 · Cited by 134 · see citing works
Curcumin is a potent modulator of microglial gene expression and migration
Karlstetter, M., der Lippe, E., Walczak, Y., Moehle, C., Aslanidis, A., Mirza, M., & Langmann, T. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-125 · Cited by 127 · cited 2× · see citing works
“It has been demonstrated that curcumin reduces the expression of several inflammatory cytokines, including IL-1α, IL-1β, IL-6, TNF, IFNγ, and many others (Figure 8) [42,43].”
Background
Curcumin binds to the α‐helical intermediate and to the amyloid form of prion protein – a new mechanism for the inhibition of PrPSc accumulation
Hafner‐Bratkovič, I., Gašperšič, J., Šmid, L. M., Bresjanac, M., & Jerala, R. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.05105.x · Cited by 126 · cited 1× · see citing works
“[32] reported that the binding of curcumin to the α-intermediate could block conformational change into the β-structure, and that the binding of curcumin to prion fibrils could prevent further growth, thus, the formation of new seeds.”
Background
Neuroprotective effect of curcumin-loaded lactoferrin nano particles against rotenone induced neurotoxicity
Bollimpelli, V. S., Kumar, P., Kumari, S., & Kondapi, A. K. (2016) · Neurochemistry International · doi:10.1016/j.neuint.2016.01.006 · Cited by 121 · cited 1× · see citing works
“[132] elaborated lactoferrin nanoparticles by sol-oil chemistry, which were loaded with curcumin (Lf-NP-Cur).”
Inhibition of Protease-Resistant Prion Protein Accumulation In Vitro by Curcumin
Caughey, B. W., Raymond, L. D., Raymond, G. J., Maxson, L., Silveira, J. R., & Baron, G. S. (2003) · Journal of Virology · doi:10.1128/jvi.77.9.5499-5502.2003 · Cited by 119 · cited 1× · see citing works
“[33] concluded in their work that curcumin inhibits prion protein resistance (PrP-Res) accumulation in neuroblastoma cells infected with the scrapie agent.”
Background
Hyaluronic acid/chitosan nanoparticles for delivery of curcuminoid and its in vitro evaluation in glioma cells
Liu, Y., Gao, S., Asghar, S., Liu, G., Song, J., Wang, X., Ping, Q. N., Zhang, C., & Xiao, Y. (2014) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2014.10.039 · Cited by 116 · see citing works
Enhanced bioavailability and bioefficacy of an amorphous solid dispersion of curcumin
Chuah, A. M., Jacob, B., Zhang, J., Ramesh, S., Mandal, S., Puthan, J. K., Deshpande, P., Vaidyanathan, V. V., Gelling, R. W., Patel, G. K., et al. (2014) · Food Chemistry · doi:10.1016/j.foodchem.2014.01.108 · Cited by 116 · cited 1× · see citing works
“In other studies, curcumin revealed an increase of >1000 times when it was formulated as ASD in hydroxypropyl methylcellulose matrixes [67].”
Background
Theoretical study on Curcumin: A comparison of calculated spectroscopic properties with NMR, UV–vis and IR experimental data
Benassi, R., Ferrari, É., Lazzari, S., Spagnolo, F., & Saladini, M. (2008) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2008.05.024 · Cited by 112 · cited 2× · see citing works
“The C=O t t i i ration of t e carboxylic groups (methyl esters and triglycerides) can be attributed to the strong and at 1510 cm−1 [18].”
Background
Bioavailability of curcumin and curcumin glucuronide in the central nervous system of mice after oral delivery of nano-curcumin
Szymusiak, M., Hu, X., León-Plata, P., Ciupinski, P., Wang, Z. J., & Liu, Y. (2016) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2016.07.027 · Cited by 109 · cited 1× · see citing works
“3 Bioavailability in the CNS (in vivo model) [99]”
Background
Curcumin-loaded chitosan-alginate-STPP nanoparticles ameliorate memory deficits and reduce glial activation in pentylenetetrazol-induced kindling model of epilepsy
Hashemian, M., Anissian, D., Ghasemi‐Kasman, M., Akbari, A., Khalili-Fomeshi, M., Ghasemi, S., Ahmadi, F., Moghadamnia, A. A., & Ebrahimpour, A. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.07.025 · Cited by 104 · cited 1× · see citing works
“Chitosan-alginate 50 Epilepsy (in vivo model) [103]”
Curcumin-loaded chitosan–bovine serum albumin nanoparticles potentially enhanced Aβ 42 phagocytosis and modulated macrophage polarization in Alzheimer’s disease
Yang, R., Zheng, Y., Wang, Q., & Zhao, L. (2018) · Nanoscale Research Letters · doi:10.1186/s11671-018-2759-z · Cited by 99 · see citing works
A cost-effective method to prepare curcumin nanosuspensions with enhanced oral bioavailability
Wang, Y., Wang, C., Zhao, J., Ding, Y., & Li, L. (2016) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2016.09.003 · Cited by 97 · cited 1× · see citing works
“[68] found an increase in the oral bioavailability of curcumin of about three to four times after the administration of curcumin in nanosuspensions in rats.”
Curcumin-lipoic acid conjugate as a promising anticancer agent on the surface of gold‑iron oxide nanocomposites: A pH-sensitive targeted drug delivery system for brain cancer theranostics
Ghorbani, M., Bigdeli, B., Jalili‐Baleh, L., Baharifar, H., Akrami, M., Dehghani, S., Goliaei, B., Amani, A., Lotfabadi, A., Rashedi, H., et al. (2017) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2017.12.008 · Cited by 96 · see citing works
PLA/PLGA nanoparticles for delivery of drugs across the blood-brain barrier
Li, J., & Sabliov, C. M. (2013) · Nanotechnology Reviews · doi:10.1515/ntrev-2012-0084 · Cited by 90 · see citing works
Effects of curcumin-loaded PLGA nanoparticles on the RG2 rat glioma model
Orunoğlu, M., Kaffashi, A., Pehlivan, S. B., Şahin, S., Söylemezoğlu, F., Oğuz, K. K., & Mut, M. (2017) · Materials Science and Engineering C · doi:10.1016/j.msec.2017.03.292 · Cited by 87 · cited 1× · see citing works
“22 EE = 35 Glioblastoma (in vitro and in vivo models) [111]”
Background
Relevance of the Anti-Inflammatory Properties of Curcumin in Neurodegenerative Diseases and Depression
Tizabi, Y., Hurley, L. L., Qualls, Z., & Akinfiresoye, L. R. (2014) · Molecules · doi:10.3390/molecules191220864 · Cited by 83 · cited 2× · see citing works
“It has been demonstrated that curcumin reduces the expression of several inflammatory cytokines, including IL-1α, IL-1β, IL-6, TNF, IFNγ, and many others (Figure 8) [42,43].”
Background
Curcumin inhibits interferon-γ signaling in colonic epithelial cells
Midura‐Kiela, M. T., Radhakrishnan, V. M., Larmonier, C. B., Laubitz, D., Ghishan, F. K., & Kiela, P. R. (2011) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00275.2011 · Cited by 77 · cited 1× · see citing works
“[53] studied the interaction of IFN-γ and curcumin in epithelial cells.”
Background
Synthesis of Alginate-Curcumin Nanocomposite and Its Protective Role in TransgenicDrosophilaModel of Parkinson’s Disease
Siddique, Y. H., Khan, W., Singh, B. R., & Naqvi, A. H. (2013) · ISRN Pharmacology · doi:10.1155/2013/794582 · Cited by 77 · cited 1× · see citing works
“Therefore, this report provided a rationale for employing curcumin-encapsulated nanoparticles in preclinical and clinical studies [131].”
Background
Curcumin-loaded lipid nanocarrier for improving bioavailability, stability and cytotoxicity against malignant glioma cells
Kumar, A., Ahuja, A., Ali, J., & Baboota, S. (2016) · Drug Delivery · doi:10.3109/10717544.2014.909906 · Cited by 76 · cited 1× · see citing works
“137, Ψ = −37 Malignant glioma cells (in vitro model) [116]”
Background
In vitro characterization and in vivo evaluation of nanostructured lipid curcumin carriers for intragastric administration
Fang, M., Jin, J., Bao, Gao, Xu, Wang, Wang, YAO, Y., & Liu (2012) · International Journal of Nanomedicine · doi:10.2147/ijn.s36257 · Cited by 73 · cited 1× · see citing works
“21 Pharmacokinetic and biodistribution (in vivo model) [93]”
Background
Neuronal CCL2 expression drives inflammatory monocyte infiltration into the brain during acute virus infection
Howe, C. L., LaFrance‐Corey, R. G., Goddery, E. N., Johnson, R. K., & Mirchia, K. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-1015-2 · Cited by 72 · cited 1× · see citing works
“Similarly, the suppression of CCL2 function may decrease the attraction of cells of the immune system to the sites of inflammation, which could result in a slowdown of the advancement of inflammation [50].”
Background
Neuronal Uptake and Neuroprotective Properties of Curcumin-Loaded Nanoparticles on SK-N-SH Cell Line: Role of Poly(lactide-co-glycolide) Polymeric Matrix Composition
Paka, G. D., Doggui, S., Zaghmi, A., Safar, R., Dao, L. H., Reisch, A., Klymchenko, A. S., Roullin, G., Joubert, O., & Ramassamy, C. (2015) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.5b00611 · Cited by 71 · cited 1× · see citing works
“[128] evaluated the antioxidant and anti-inflammatory activities of curcumin-loaded PLGA nanoparticles (Cur–PLGA–NP) in SK-N-SH cells, which are human neuroblastoma-derived cells.”
Background
Antidepressant effects of curcumin and HU-211 coencapsulated solid lipid nanoparticles against corticosterone-induced cellular and animal models of major depression
He, X., Zhu, Y., Wang, M., Jing, G., Zhu, R., & Wang, S. (2016) · International Journal of Nanomedicine · doi:10.2147/ijn.s109088 · Cited by 70 · cited 1× · see citing works
“61 Major depression (in vitro and in vivo models) [85]”
Background
Dual‐Targeting Lactoferrin‐Conjugated Polymerized Magnetic Polydiacetylene‐Assembled Nanocarriers with Self‐Responsive Fluorescence/Magnetic Resonance Imaging for In Vivo Brain Tumor Therapy
Fang, J., Chiu, T., Huang, W., Lai, Y., Hu, S., Chen, Y., & Chen, S. (2016) · Advanced Healthcare Materials · doi:10.1002/adhm.201500750 · Cited by 68 · cited 1× · see citing works
“3 Orthotopic Brain Tumor-Bearing Rat (in vitro and in vivo models) [123]”
Background
Evaluation of the antioxidant properties of curcumin derivatives by genetic function algorithm
Alisi, I. O., Uzairu, A., Abechi, S. E., & Idris, S. O. (2018) · Journal of Advanced Research · doi:10.1016/j.jare.2018.03.003 · Cited by 67 · see citing works
Curcumin Alters the Salt Bridge-containing Turn Region in Amyloid β(1–42) Aggregates
Mithu, V. S., Sarkar, B., Bhowmik, D., Das, A. K., Chandrakesan, M., Maiti, S., & Madhu, P. K. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.519447 · Cited by 66 · cited 1× · see citing works
“[36] reported that curcumin disorganizes Aβ fibrils; the disruption of Aβ-fibrils was achieved by means of structural changes in the salt bridge region and near the C terminus.”
Enhanced solubility and dissolution of curcumin by a hydrophilic polymer solid dispersion and its insilico molecular modeling studies
Gangurde, A. B., Kundaikar, H., Javeer, S. D., Jaiswar, D. R., Degani, M. S., & Amin, P. D. (2015) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2015.08.005 · Cited by 59 · cited 2× · see citing works
“[66], the authors demonstrated that curcumin formulated in an Eudragit E (Evonik Nutrition & Care GmbH, Essen, Germany) polymeric matrix dissolved more rapidly (20–45% release after 60 minutes) than curcumin alone (2–5% release after 120 minutes) at pH 1.”
Enhanced Oral Bioavailability of Curcumin Using a Supersaturatable Self-Microemulsifying System Incorporating a Hydrophilic Polymer; In Vitro and In Vivo Investigations
Jaisamut, P., Wiwattanawongsa, K., Graidist, P., Sangsen, Y., & Wiwattanapatapee, R. (2017) · AAPS PharmSciTech · doi:10.1208/s12249-017-0857-3 · Cited by 59 · see citing works
ApoE3 mediated polymeric nanoparticles containing curcumin: Apoptosis induced in vitro anticancer activity against neuroblastoma cells
Mulik, R. S., Mönkkönen, J., Juvonen, R. O., Mahadik, K. R., & Paradkar, A. R. (2012) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2012.07.062 · Cited by 58 · cited 1× · see citing works
“85 Anticancer activity in neuroblastoma cells (in vitro model) [98]”
Background
Anti-Inflammatory Potency of Nano-Formulated Puerarin and Curcumin in Rats Subjected to the Lipopolysaccharide-Induced Inflammation
Singh, A. K., Jiang, Y., Gupta, S., Younus, M., & Ramzan, M. (2013) · Journal of Medicinal Food · doi:10.1089/jmf.2012.0049 · Cited by 57 · cited 1× · see citing works
“Metallic nanoparticles Au PEG Lipopolysaccharide-induced inflammation (in vitro and in vivo models) [119]”
Background
Hansen solubility parameters (HSP) for prescreening formulation of solid lipid nanoparticles (SLN): in vitro testing of curcumin-loaded SLN in MCF-7 and BT-474 cell lines
Doktorovová, S., Souto, E. B., & Silva, A. M. (2017) · Pharmaceutical Development and Technology · doi:10.1080/10837450.2017.1384491 · Cited by 56 · see citing works
Curcumin Inhibits LPS-Induced CCL2 Expression via JNK Pathway in C6 Rat Astrocytoma Cells
Zhang, Z.-J., Zhao, L.-X., Cao, D.-L., Zhang, X., Gao, Y.-J., & Xia, C.-L. (2012) · Cellular and molecular neurobiology · doi:10.1007/s10571-012-9816-4 · Cited by 55 · cited 1× · see citing works
“[51] investigated the inhibitory effect of curcumin on lipopolysaccharide (LPS)-induced chemokine CCL production.”
Background
Inhibition of IL-6 Signaling Pathway by Curcumin in Uterine Decidual Cells
Devi, Y. S., DeVine, M., DeKuiper, J. L., Ferguson, S. D., & Fazleabas, A. T. (2015) · PLoS ONE · doi:10.1371/journal.pone.0125627 · Cited by 54 · cited 2× · see citing works
“[46] reported that curcumin could ex rt a direct effect on constitu ive ignal tr sducer and activator of transcription 3 (STAT3) phosphorylation.”
Background
Ameliorating Amyloid-β Fibrils Triggered Inflammation via Curcumin-Loaded Polymeric Nanoconstructs
Ameruoso, A., Palomba, R., Palange, A. L., Cervadoro, A., Lee, A., Mascolo, D. D., & Decuzzi, P. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01411 · Cited by 53 · cited 1× · see citing works
“31 Inflammation model (in vitro model) [96]”
Design and evaluation of lipoprotein resembling curcumin-encapsulated protein-free nanostructured lipid carrier for brain targeting
Meng, F., Asghar, S., Xu, Y., Wang, J., Jin, X., Wang, Z., Wang, J., Ping, Q. N., Zhou, J., & Xiao, Y. (2016) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2016.04.033 · Cited by 52 · cited 1× · see citing works
“29 Biodistribution (in vitro and in vivo models) [95]”
Background
Development of Nasal Lipid Nanocarriers Containing Curcumin for Brain Targeting
Vaz, G. R., Hädrich, G., Bidone, J., Rodrigues, J. L., Falkembach, M., Putaux, J., Hort, M. A., Monserrat, J. M., Varela, A. S., Teixeira, H. F., et al. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-160355 · Cited by 50 · cited 1× · see citing works
“7 EE ≥ 99 Permeation in Franz cells (ex vivo model) [118]”
Background
Curcumin Attenuates Opioid Tolerance and Dependence by Inhibiting Ca2+/Calmodulin-Dependent Protein Kinase II α Activity
Hu, X., Huang, F. P., Szymusiak, M., Liu, Y., & Wang, Z. J. (2014) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.114.219303 · Cited by 49 · cited 1× · see citing works
“PLGA Opioid tolerance and dependence (in vivo model) [101]”
Background
Curcumin nanoconjugate inhibits aggregation of N-terminal region (Aβ-16) of an amyloid beta peptide
Brahmkhatri, V. P., Sharma, N., Sunanda, P., D’Souza, A., Raghothama, S., & Atreya, H. S. (2018) · New Journal of Chemistry · doi:10.1039/c8nj03541e · Cited by 49 · cited 1× · see citing works
“[35] reported that curcumin-loaded gold nanoparticles inhibited Aβ aggregation, and that these were capable of dissolving aggregates.”
Background
Preparation and in-vitro/in-vivo evaluation of curcumin nanosuspension with solubility enhancement
Li, X., Yuan, H., Zhang, C., Chen, W., Cheng, W., Chen, X., & Ye, X. (2016) · Journal of Pharmacy and Pharmacology · doi:10.1111/jphp.12575 · Cited by 48 · cited 1× · see citing works
“[69] found an increase in bioavailability after the intravenous administration of a nanosuspension of about 4.”
Background
Curcumin Blocks Interleukin-1 (IL-1) Signaling by Inhibiting the Recruitment of the IL-1 Receptor–Associated Kinase IRAK in Murine Thymoma EL-4 Cells
Jurrmann, N., Brigelius‐Flohé, R., & Böl, G. (2005) · Journal of Nutrition · doi:10.1093/jn/135.8.1859 · Cited by 47 · cited 6× · see citing works
“Some authors have reported that curcumin suppresses the expression of IL-1β [44,45].”
BackgroundInfluential
Curcumin blocks CCL2-induced adhesion, motility and invasion, in part, through down-regulation of CCL2 expression and proteolytic activity
Roselli (2009) · International Journal of Oncology · doi:10.3892/ijo_00000259 · Cited by 45 · cited 1× · see citing works
“[52] suggested that curcumin downregulates CCL2 activity via the inhibition of protein kinase C (PKC) and matrix metalloproteinases.”
Background
PREPARATION AND CHARACTERIZATION OF CURCUMIN LOADED CASSAVA STARCH NANOPARTICLES WITH IMPROVED CELLULAR ABSORPTION
Athira, G. K., & Jyothi, A. N. (2014) · International Journal of Pharmacy and Pharmaceutical Sciences · Cited by 44 · see citing works
“Curcumin-loaded Poly (d, l-lactide-co-glycolide) nanovesicles induce antinociceptive effects and reduce pronociceptive cytokine and BDNF release in spinal cord after acute administration in mice”
Pieretti, S., Ranjan, A. P., Giannuario, A. D., Mukerjee, A., Marzoli, F., Giovannandrea, R. D., & Vishwanatha, J. K. (2017) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2017.07.027 · Cited by 33 · see citing works
Cyclic hexapeptide-conjugated nanoparticles enhance curcumin delivery to glioma tumor cells and tissue
Zhang, X., Li, X., Hua, H., Wang, A., Liu, W., Li, Y., Fu, F., Shi, Y., & Sun, K. (2017) · International Journal of Nanomedicine · doi:10.2147/ijn.s138501 · Cited by 30 · cited 1× · see citing works
“5 Glioma tumor cells (in vitro and in vivo models) [109]”
Background
Curcumin loading potentiates the neuroprotective efficacy of Fe3O4 magnetic nanoparticles in cerebellum cells of schizophrenic rats
Naserzadeh, P., Hafez, A. A., Abdorahim, M., Abdollahifar, M., Shabani, R., Peirovi, H., Simchi, A., & Ashtari, K. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.09.106 · Cited by 30 · cited 1× · see citing works
“5, EE = 75 Schizophrenic rats (in vivo model) [122]”
Background
Comparative analysis of protective effects of curcumin, curcumin-β-cyclodextrin nanoparticle and nanoliposomal curcumin on unsymmetrical dimethyl hydrazine poisoning in mice
Li, W., Zhou, M., Xu, N., Hu, Y. X., Wang, C., Li, D., Liu, L., & Li, D. (2016) · Bioengineered · doi:10.1080/21655979.2016.1197029 · Cited by 27 · see citing works
Effect of curcumin on expressions of NF-κBp65, TNF-α and IL-8 in placental tissue of premature birth of infected mice
Guo, Y., He, P., & Feng, A. (2017) · Asian Pacific Journal of Tropical Medicine · doi:10.1016/j.apjtm.2017.01.004 · Cited by 27 · see citing works
The Antioxidant Effect of Curcumin on Cochlear Fibroblasts in Rat Models of Diabetes Mellitus.
Haryuna, T. S. H., Munir, D., María, A., & Bashiruddin, J. (2017) · PubMed Central · doi:10.22038/ijorl.2017.19603.1660 · Cited by 19 · cited 1× · see citing works
“[62] investigated the antioxidant action of curcumin against oxidative stress caused by diabetes mellitus.”
Background
Epoxy Resin Beads as a Pharmaceutical Dosage Form II: Dissolution Studies of Epoxy-Amine Beads and Release of Drug
Khanna, S. C., Soliva, M., & Speiser, P. P. (1969) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600581120 · Cited by 14 · cited 1× · see citing works
“However, the materialization of the investigation of new carriers for the transport of drugs to the brain with the use of nanoparticles dates from the first conceptions of Peter Speiser in 1969 [79].”
Background
TO ENHANCE THE SOLUBILITY OF CURCUMIN BY SOLID SELF-MICROEMULSIFYING DRUG DELIVERY SYSTEM (SMEDDS).
Bele, M. H. (2017) · Zenodo (CERN European Organization for Nuclear Research) · doi:10.5281/zenodo.2526128 · Cited by 3 · see citing works

Flagged first, then by citations

Research works printed but not linked: 3

[2]Alsamydai A. Jaber N. Pharmacological aspects of curcumin: Review article Int. J. Pharmacogn. 2018 5 313 326
[15]Subramani P.A. Panati K. Lebaka V.R. Redd D.D. Narala V.R. Nanostructures for curcumin delivery: Posibilities and challenges Nano and -Micro Drug Delivery Systems Andrew W. Elsevier Science Ltd Desing and Fabrication Amsterdam, The Netherlands 2017 393 418
[20]O’Neil M.J. The Merck Index, An Encyclopedia of Chemicals, Drugs, and Biologicals 15th ed. Royal Society of Chemistry Cambridge, UK 2013

Sorted by citations

Natural Products and Their Bioactive Compounds: Neuroprotective Potentials against Neurodegenerative Diseases
Sairazi, N. S. M., & Sirajudeen, K. N. S. (2020) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2020/6565396 · Cited by 250 · see citing works
Nanoformulations of Herbal Extracts in Treatment of Neurodegenerative Disorders
Moradi, S. Z., Momtaz, S., Bayrami, Z., Farzaei, M. H., & Abdollahi, M. R. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.00238 · Cited by 181 · see citing works
Therapeutic Potential of Natural Products in Treating Neurodegenerative Disorders and Their Future Prospects and Challenges
Rahman, M. H., Bajgai, J., Fadriquela, A., Sharma, S., Trinh, T. T., Akter, R., Jeong, Y. J., Goh, S. H., Kim, C.-S., & Lee, K.-J. (2021) · Molecules · doi:10.3390/molecules26175327 · Cited by 182 · see citing works
Chronic Inflammatory Diseases, Anti-Inflammatory Agents and Their Delivery Nanosystems
Plachá, D., & Jampílek, J. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13010064 · Cited by 177 · see citing works
Molecular mechanism of curcumin action in signaling pathways: Review of the latest research
Liczbiński, P., Michałowicz, J., & Bukowska, B. (2020) · Phytotherapy Research · doi:10.1002/ptr.6663 · Cited by 168 · see citing works
Curcumin, Hormesis and the Nervous System
Scuto, M. C., Mancuso, C., Tomasello, B., Ontario, M. L., Cavallaro, A. S., Frasca, F., Maiolino, L., Salinaro, A. T., Calabrese, E. J., & Calabrese, V. (2019) · Nutrients · doi:10.3390/nu11102417 · Cited by 155 · see citing works
Natural Compounds as Inhibitors of Aβ Peptide Aggregation: Chemical Requirements and Molecular Mechanisms
Pagano, K., Tomaselli, S., Molinari, H., & Ragona, L. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.619667 · Cited by 137 · see citing works
“…capable to penetrate the BBB (Barbara et al., 2017), many drug delivery systems and formulations were investigated including liposomes, solid lipid microparticles, cyclodextrins, and nanoparticles using both natural or synthetic polymers (Barbara et al., 2017; Del Prado-Audelo et al., 2019).”
Background
Curcumin-Based Nanomedicines in the Treatment of Inflammatory and Immunomodulated Diseases: An Evidence-Based Comprehensive Review
Laurindo, L. F., de Carvalho, G. M., Zanuso, B. D. O., Figueira, M. E., Direito, R., Goulart, R. D. Á., Buglio, D. S., & Barbalho, S. M. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15010229 · Cited by 128 · see citing works
Multi-Target Mechanisms of Phytochemicals in Alzheimer’s Disease: Effects on Oxidative Stress, Neuroinflammation and Protein Aggregation
Sharifi-Rad, J., Rapposelli, S., Sestito, S., Herrera-Bravo, J., Arancibia-Diaz, A., Salazar, L. A., Yeskaliyeva, B., Beyatli, A., Leyva-Gómez, G., González-Contreras, C., et al. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12091515 · Cited by 125 · see citing works
Self-citation
The Credible Role of Curcumin in Oxidative Stress-Mediated Mitochondrial Dysfunction in Mammals
Sathyabhama, M., Dharshini, L. C. P., Karthikeyan, A., Senthil, K., & Min, T. (2022) · Biomolecules · doi:10.3390/biom12101405 · Cited by 115 · see citing works
“S-transferases (GST), and glutathione peroxidase (GPx) adapted from [39,40,44,45].”
Background
Potential therapeutic effects of curcumin mediated by JAK/STAT signaling pathway: A review
Ashrafizadeh, M., Rafiei, H., Mohammadinejad, R., Afshar, E. G., Farkhondeh, T., & Samarghandian, S. (2020) · Phytotherapy Research · doi:10.1002/ptr.6642 · Cited by 114 · see citing works
A Reevaluation of Chitosan-Decorated Nanoparticles to Cross the Blood-Brain Barrier
Cortés, H., Alcalá-Alcalá, S., Caballero-Florán, I. H., Bernal-Chávez, S. A., Ávalos‐Fuentes, A., González‐Torres, M., Carmen, M. G., Figueroa‐González, G., Reyes‐Hernández, O. D., Florán, B., et al. (2020) · Membranes · doi:10.3390/membranes10090212 · Cited by 108 · see citing works
Self-citation
Therapeutic Applications of Curcumin Nanomedicine Formulations in Cardiovascular Diseases
Salehi, B., Prado-Audelo, M. L. D., Cortés, H., Leyva‐Gómez, G., Stojanović-Radić, Z. Z., Singh, Y. D., Patra, J. K., Das, G., Martins, N. A., Martorell, M., et al. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9030746 · Cited by 99 · see citing works
“The use of organic solvents such as acetone and ethyl acetate for the internal phase of emulsions allows rapid solubility of the drug and subsequent solvent removal [91].”
BackgroundMethodInfluentialSelf-citation
Mutual Two-Way Interactions of Curcumin and Gut Microbiota
Pluta, R. M., Januszewski, S., & Ułamek-Kozioł, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21031055 · Cited by 90 · see citing works
Dietary Polyphenols: A Multifactorial Strategy to Target Alzheimer’s Disease
Dhakal, S., Kushairi, N., Phan, C., Adhikari, B., Sabaratnam, V., & Macreadie, I. G. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20205090 · Cited by 89 · see citing works
Transferrin-functionalized lipid nanoparticles for curcumin brain delivery
Neves, A. R., van der Putten, L., Queiroz, J. F., Pinheiro, M., & Reis, S. (2021) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2021.03.010 · Cited by 87 · see citing works
Enhanced neuroprotective and antidepressant activity of curcumin-loaded nanostructured lipid carriers in lipopolysaccharide-induced depression and anxiety rat model
Rubab, S., Naeem, K., Rana, I., Khan, N., Afridi, M., Ullah, I., Shah, F. A., Sarwar, S., Din, F. U., Choi, H.-I., et al. (2021) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2021.120670 · Cited by 85 · see citing works
Innovative Delivery Systems for Curcumin: Exploring Nanosized and Conventional Formulations
Yakubu, J., & Pandey, A. V. (2024) · Pharmaceutics · doi:10.3390/pharmaceutics16050637 · Cited by 82 · see citing works
Emerging Trends in Topical Delivery of Curcumin Through Lipid Nanocarriers: Effectiveness in Skin Disorders
Waghule, T., Gorantla, S., Rapalli, V. K., Shah, P., Dubey, S. K., Saha, R. N., & Singhvi, G. (2020) · AAPS PharmSciTech · doi:10.1208/s12249-020-01831-9 · Cited by 80 · see citing works
Nano‐Derived Therapeutic Formulations with Curcumin in Inflammation‐Related Diseases
Quispe, C., Martins, N. A., Manca, M. L., Manconi, M., Sytar, O., Hudz, N., Shanaida, M., Kumar, M., Taheri, Y., Martorell, M., et al. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/3149223 · Cited by 80 · see citing works
Curcumin-based nanotechnology approaches and therapeutics in restoration of autoimmune diseases
Rahiman, N., Markina, Y. V., Kesharwani, P., Johnston, T. P., & Sahebkar, A. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.05.046 · Cited by 79 · see citing works
Optimization of Curcumin Nanocrystals as Promising Strategy for Nose-to-Brain Delivery Application
Bonaccorso, A., Gigliobianco, M. R., Pellitteri, R., Santonocito, D., Carbone, C., Martino, P. D., Puglisi, G., & Musumeci, T. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12050476 · Cited by 77 · see citing works
“, molecular weight, solubility, lipophilicity, degree of dissociation, stability, dose, and volume of dose administered) many encapsulation technologies have been developed [11,12].”
siRNA‐based nanotherapeutics as emerging modalities for immune‐mediated diseases: A preliminary review
Sargazi, S., Arshad, R., Ghamari, R., Rahdar, A., Bakhshi, A., Fathi‐karkan, S., Ajalli, N., Bilal, M., & Diez-Pascual, A. M. (2022) · Cell Biology International · doi:10.1002/cbin.11841 · Cited by 77 · see citing works
Combination Therapy Comprising Paclitaxel and 5-Fluorouracil by Using Folic Acid Functionalized Bovine Milk Exosomes Improves the Therapeutic Efficacy against Breast Cancer
Kumar, D. N., Chaudhuri, A., Dehari, D., Shekher, A., Gupta, S., Majumdar, S., Krishnamurthy, S., Singh, S., Kumar, D., & Agrawal, A. (2022) · Life · doi:10.3390/life12081143 · Cited by 73 · see citing works
Synthesis, characterization and evaluation of anti-arthritic and anti-inflammatory potential of curcumin loaded chitosan nanoparticles
Asif, H. M., Zafar, F., Ahmad, K., Iqbal, A., Shaheen, G., Ansari, K. A., Rana, S., Zahid, R., & Ghaffar, S. (2023) · Scientific Reports · doi:10.1038/s41598-023-37152-7 · Cited by 75 · see citing works
Nanocarrier mediated drug delivery as an impeccable therapeutic approach against Alzheimer’s disease
Taliyan, R., Kakoty, V., Sarathlal, K. C., Kharavtekar, S. S., Karennanavar, C. R., Choudhary, Y. K., Singhvi, G., Riadi, Y., Dubey, S. K., & Kesharwani, P. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.01.044 · Cited by 76 · see citing works
Effect of nano‐curcumin on various diseases: A comprehensive review of clinical trials
Hassanizadeh, S., Shojaei, M., Bagherniya, M., Orekhov, A. N., & Sahebkar, A. (2023) · BioFactors · doi:10.1002/biof.1932 · Cited by 73 · see citing works
Curcumin nanoparticles: physicochemical fabrication, characterization, antioxidant, enzyme inhibition, molecular docking and simulation studies
Kanwal, Q., Ahmed, M., Hamza, M., Ahmad, M., Atiq‐ur‐Rehman, Yousaf, N., Javaid, A., Anwar, A., Khan, I. H., & Muddassar, M. (2023) · RSC Advances · doi:10.1039/d3ra01432k · Cited by 73 · see citing works
Antitumor Activity of Curcumin in Glioblastoma
Walker, B. C., & Mittal, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21249435 · Cited by 71 · see citing works
Curcumin as a novel reducing and stabilizing agent for the green synthesis of metallic nanoparticles
Patra, D., & Kurdi, R. E. (2021) · Green Chemistry Letters and Reviews · doi:10.1080/17518253.2021.1941306 · Cited by 68 · see citing works
Recent Advances in Nanotechnology with Nano-Phytochemicals: Molecular Mechanisms and Clinical Implications in Cancer Progression
Kim, B., Park, J.-E., Im, E., Cho, Y., Lee, J., Lee, H., Sim, D. Y., Park, W.-Y., Shim, B., & Kim, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22073571 · Cited by 65 · see citing works
Development and Evaluation of Alginate Membranes with Curcumin-Loaded Nanoparticles for Potential Wound-Healing Applications
Guadarrama-Acevedo, M. C., Mendoza-Flores, R. A., Prado-Audelo, M. L. D., Urbán‐Morlán, Z., Giraldo‐Gómez, D. M., Magaña, J. J., González‐Torres, M., Reyes‐Hernández, O. D., Figueroa‐González, G., Caballero-Florán, I. H., et al. (2019) · Pharmaceutics · doi:10.3390/pharmaceutics11080389 · Cited by 64 · see citing works
Self-citation
Curcumin Loaded Chitosan-Protamine Nanoparticles Revealed Antitumor Activity Via Suppression of NF-κB, Proinflammatory Cytokines and Bcl-2 Gene Expression in the Breast Cancer Cells
Abdel-Hakeem, M. A., Mongy, S., Hassan, B., Tantawi, O. I., & Badawy, I. (2021) · Journal of Pharmaceutical Sciences · doi:10.1016/j.xphs.2021.06.004 · Cited by 61 · see citing works
Curcumin activates Nrf2 through PKCδ-mediated p62 phosphorylation at Ser351
Park, J.-Y., Sohn, H., Koh, Y. H., & Jo, C. (2021) · Scientific Reports · doi:10.1038/s41598-021-87225-8 · Cited by 62 · see citing works
Nanoemulsion Improves the Neuroprotective Effects of Curcumin in an Experimental Model of Parkinson’s Disease
Ramires, O., Alves, B. M. D. S., Barros, P., Rodrigues, J. L., Ferreira, S. P., Monteiro, L. K. S., Araújo, G. D. M. S., Fernandes, S. S., Vaz, G., Dora, C. L., et al. (2021) · Neurotoxicity research · doi:10.1007/s12640-021-00362-w · Cited by 44 · see citing works
The Role of Natural Antioxidants in the Prevention of Dementia—Where Do We Stand and Future Perspectives
Jurcău, A. (2021) · Nutrients · doi:10.3390/nu13020282 · Cited by 55 · see citing works
“New formulations, such as encapsulation in nanoparticles, liposomes, self-micro-emulsifying delivery systems, or apomorphous solid dispersions are trying to overcome the barriers imposed by the pharmacokinetics of curcumin [199].”
Background
Leveraging hallmark Alzheimer’s molecular targets using phytoconstituents: Current perspective and emerging trends
Dhage, P. A., Sharbidre, A. A., Dakua, S. P., & Balakrishnan, S. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111634 · Cited by 53 · see citing works
Curcumin: Could This Compound Be Useful in Pregnancy and Pregnancy-Related Complications?
Filardi, T., Varı́, R., Ferretti, E., Zicari, A., Morano, S., & Santangelo, C. (2020) · Nutrients · doi:10.3390/nu12103179 · Cited by 51 · see citing works
Recent Advances in Nanoencapsulation Systems Using PLGA of Bioactive Phenolics for Protection against Chronic Diseases
Rahim, R. A., Jayusman, P. A., Muhammad, N., Ahmad, F., Mokhtar, N. M., Mohamed, I. N., Mohamed, N., & Shuid, A. N. (2019) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph16244962 · Cited by 49 · see citing works
Stable nanoemulsions for poorly soluble curcumin: From production to digestion response in vitro
Ye, Q., Kwon, S., Gu, Z., & Selomulya, C. (2023) · Journal of Molecular Liquids · doi:10.1016/j.molliq.2023.123720 · Cited by 49 · see citing works
PLGA-Based Curcumin Delivery System: An Interesting Therapeutic Approach in the Treatment of Alzheimer's Disease
Shahbaz, S. K., Koushki, K., Sathyapalan, T., Majeed, M., & Sahebkar, A. (2021) · Current Neuropharmacology · doi:10.2174/1570159x19666210823103020 · Cited by 49 · see citing works
“Recent studies focused on curcumin-loaded nanoparticle delivery systems, specific CNS targeting, and intranuclear levels in neurons [150].”
BackgroundMethod
Nature's toolbox against tau aggregation: An updated review of current research
Khan, S., Hassan, M. I., Shahid, M., & Islam, A. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.101924 · Cited by 50 · see citing works
Liposomal Encapsulated Curcumin Effectively Attenuates Neuroinflammatory and Reactive Astrogliosis Reactions in Glia Cells and Organotypic Brain Slices
Schmitt, C. R., Lechanteur, A., Cossais, F., Bellefroid, C., Arnold, P., Lucius, R., Held‐Feindt, J., Piel, G., & Hattermann, K. (2020) · International Journal of Nanomedicine · doi:10.2147/ijn.s245300 · Cited by 46 · see citing works
A comprehensive review of the therapeutic potential of curcumin nanoformulations
Khezri, K., Saeedi, M., Mohammadamini, H., & Zakaryaei, A. S. (2021) · Phytotherapy Research · doi:10.1002/ptr.7190 · Cited by 46 · see citing works
Co-Delivery of Curcumin and Bioperine via PLGA Nanoparticles to Prevent Atherosclerotic Foam Cell Formation
Pillai, S. C., Borah, A., Le, M. N. T., Kawano, H., Hasegawa, K., & Kumar, D. S. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13091420 · Cited by 45 · see citing works
GRGDS-conjugated and curcumin-loaded magnetic polymeric nanoparticles for the hyperthermia treatment of glioblastoma cells
Şentürk, F., Çakmak, S., Koçum, İ. C., Gümüşderelı́oğlu, M., & Öztürk, G. G. (2021) · Colloids and Surfaces A Physicochemical and Engineering Aspects · doi:10.1016/j.colsurfa.2021.126648 · Cited by 45 · see citing works
Lactoferrin: neuroprotection against Parkinson's disease and secondary molecule for potential treatment
Eker, F., Bolat, E., Pekdemir, B., Duman, H., & Karav, S. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1204149 · Cited by 43 · see citing works
Application of curcumin nanoformulations in Alzheimer’s disease: prevention, diagnosis and treatment
Lv, H., Wang, Y., Yang, X., Ling, G., & Zhang, P. (2022) · Nutritional Neuroscience · doi:10.1080/1028415x.2022.2084550 · Cited by 41 · see citing works
“Polymer-based nanoformulations Polymers are the first materials to be used to deliver drugs to the brain [59].”
BackgroundInfluential
Challenges and Future Prospects: A Benefaction of Phytoconstituents on Molecular Targets Pertaining to Alzheimer’s Disease
Sharma, H., & Chandra, P. (2023) · International Journal of Pharmaceutical Investigation · doi:10.5530/ijpi.14.1.15 · Cited by 40 · see citing works
Nanodelivery of phytobioactive compounds for treating aging-associated disorders
Lushchak, O. V., Strilbytska, O. M., Koliada, A. K., Zayachkivska, A., Burdyliuk, N., Yurkevych, I. S., Storey, K. B., & Vaiserman, A. M. (2020) · GeroScience · doi:10.1007/s11357-019-00116-9 · Cited by 40 · see citing works
Antioxidant for Neurological Diseases and Neurotrauma and Bioengineering Approaches
Rizwana, N., Agarwal, V., & Nune, M. (2021) · Antioxidants · doi:10.3390/antiox11010072 · Cited by 40 · see citing works
“It consists of two aromatic rings containing phenolic groups linked by seven carbon spacers consisting of diketone moiety [81].”
Background
Evolving therapeutic interventions for the management and treatment of Alzheimer’s disease
Ahmad, F., Karan, A., Sharma, R., Sharma, N. S., Sundar, V., Jayaraj, R. L., Mukherjee, S., & DeCoster, M. A. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102229 · Cited by 38 · see citing works
Prospective Role of Polyphenolic Compounds in the Treatment of Neurodegenerative Diseases
Akter, R., Rahman, H., Behl, T., Chowdhury, M. A. R., Manirujjaman, M., Bulbul, I. J., Elshenawy, S. E., Ţiţ, D. M., & BUNGAU, S. G. (2021) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527320666210218084444 · Cited by 38 · see citing works
Curcumin and Heme Oxygenase: Neuroprotection and Beyond
Mhillaj, E., Tarozzi, A., Pruccoli, L., Cuomo, V., Trabace, L., & Mancuso, C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20102419 · Cited by 37 · see citing works
Curcumin and its analog alleviate diabetes-induced damages by regulating inflammation and oxidative stress in brain of diabetic rats
Miao, C., Chen, H., Li, Y., Guo, Y., Xu, F., Chen, Q., Zhang, Y., Hu, M., & Chen, G. (2021) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-021-00638-3 · Cited by 37 · see citing works
Curcumin Release from Biomaterials for Enhanced Tissue Regeneration Following Injury or Disease
Hamilton, A. E., & Gilbert, R. J. (2023) · Bioengineering · doi:10.3390/bioengineering10020262 · Cited by 36 · see citing works
Nose-to-brain delivery of self-assembled curcumin-lactoferrin nanoparticles: Characterization, neuroprotective effect and in vivo pharmacokinetic study
Li, L., Tan, L., Zhang, Q. Y., Cheng, Y., Liu, Y., Li, R., & Hou, S. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1168408 · Cited by 36 · see citing works
Aluminium Binding to Modified Amyloid-β Peptides: Implications for Alzheimer’s Disease
Mocanu, C. S., Jureschi, M., & Drochioiu, G. (2020) · Molecules · doi:10.3390/molecules25194536 · Cited by 34 · see citing works
Advances in Nano-Enabled Platforms for the Treatment of Depression
Mutingwende, F. P., Kondiah, P. P. D., Ubanako, P. N., Marimuthu, T., & Choonara, Y. E. (2021) · Polymers · doi:10.3390/polym13091431 · Cited by 34 · see citing works
Natural Alkaloid Compounds as Inhibitors for Alpha-Synuclein Seeded Fibril Formation and Toxicity
Ghanem, S. S., Fayed, H. S., Zhu, Q., Lu, J., Vaikath, N. N., Ponraj, J., Mansour, S. A., & El‐Agnaf, O. M. A. (2021) · Molecules · doi:10.3390/molecules26123736 · Cited by 33 · see citing works
Albumin-mediated “Unlocking” of supramolecular prodrug-like nanozymes toward selective imaging-guided phototherapy
Han, J., Li, H., Zhao, L., Kim, G., Chen, Y., Yan, X., & Yoon, J. (2022) · Chemical Science · doi:10.1039/d2sc02025d · Cited by 32 · see citing works
Curcumin and nano‐curcumin applications in psychiatric disorders
Mohammadzadeh, R., Fathi, M., Pourseif, M. M., Omidi, Y., Farhang, S., Barzegar-Jalali, M., Valizadeh, H., Nakhlband, A., & Adibkia, K. (2024) · Phytotherapy Research · doi:10.1002/ptr.8265 · Cited by 27 · see citing works
Current advancements related to phytobioactive compounds based liposomal delivery for neurodegenerative diseases
Khot, K. B., Gopan, G., Bandiwadekar, A., & Jose, J. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101806 · Cited by 25 · see citing works
Novel targets for parkinsonism-depression comorbidity
Tizabi, Y., Getachew, B., Csoka, A. B., Manaye, K. F., & Copeland, R. (2019) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2019.06.004 · Cited by 25 · see citing works
Nrf2/Keap1/ARE regulation by plant secondary metabolites: a new horizon in brain tumor management
Dewanjee, S., Bhattacharya, H., Bhattacharyya, C., Chakraborty, P., Fleishman, J. S., Alexiou, A. T., Papadakis, M., & Jha, S. K. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-024-01878-2 · Cited by 29 · see citing works
Curcumin Solubility and Bioactivity Enhancement Through Amorphization with Tryptophan via Supercritical Fluid Technology
Garbiec, E., Rosiak, N., Sip, S., Zalewski, P., & Cielecka‐Piontek, J. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26020855 · Cited by 24 · see citing works
Nanoparticles with curcumin and piperine modulate steroid biosynthesis in prostate cancer
Yakubu, J., Natsaridis, E., du Toit, T., Barata, I. S., Tagit, O., & Pandey, A. V. (2025) · Scientific Reports · doi:10.1038/s41598-025-98102-z · Cited by 24 · see citing works
Curcuma Longa, the “Golden Spice” to Counteract Neuroinflammaging and Cognitive Decline—What Have We Learned and What Needs to Be Done
Berry, A., Collacchi, B., Masella, R., Varı́, R., & Cirulli, F. (2021) · Nutrients · doi:10.3390/nu13051519 · Cited by 23 · see citing works
Potential of Ferritin-Based Platforms for Tumor Immunotherapy
Xu, X., Tian, K., Lou, X.-F., & Du, Y. (2022) · Molecules · doi:10.3390/molecules27092716 · Cited by 23 · see citing works
“In the past decade, hundreds of nanodrug delivery systems have been developed based on passive and active targeting by ferritin, including physical or chemical loading of various therapeutic drugs [8,65] (curcumin [66,67], doxorubicin [68,69], paclitaxel [70,71], and quercetin [72], among others), imaging contrast age…”
Background
Curcuma Longa-Based Green and Sustainable Antioxidants for Biopolymers
Sattar, M. A. (2024) · ACS Sustainable Chemistry & Engineering · doi:10.1021/acssuschemeng.3c07597 · Cited by 22 · see citing works
Nanoparticle-Mediated Delivery of Flavonoids for Cancer Therapy: Prevention and Treatment
Sharma, G., Nim, S., Alle, M., Husen, A., & Kim, J. (2021) · Nanotechnology in the life sciences · doi:10.1007/978-3-030-84262-8_3 · Cited by 22 · see citing works
Updates on Titanium Dioxide
Bejaoui, B. (2023) · IntechOpen eBooks · doi:10.5772/intechopen.104130 · Cited by 21 · see citing works
The Effects of Curcumin on Neurodegenerative Diseases: a Systematic Review
Bássoli, R. M. F., Audi, D., Ramalho, B. J., Audi, M., Quesada, K. R., & Barbalho, S. M. (2023) · Journal of Herbal Medicine · doi:10.1016/j.hermed.2023.100771 · Cited by 21 · see citing works
Green nanotechnology: nanoparticle synthesis using Curcuma amada , Curcuma caesia , Curcuma longa , and Curcuma zedoaria
Gangal, A., Sethiya, N. K., Duseja, M., Shukla, R. K., Bisht, D., Rana, V. S., Lalhlenmawia, H., Azizov, S., & Kumar, D. (2025) · Green Chemistry Letters and Reviews · doi:10.1080/17518253.2024.2449122 · Cited by 21 · see citing works
“In another study, PLGA nanoparticles encapsulating curcumin (197), formulation of curcumin-loaded SLN (198), formulations of curcumin nanoparticles for brain diseases (199), and curcumin-loaded electrospun nanofibers for the management of the biofilm-associated infections were discussed (200).”
Solid-State 1H, 13C, and 17O NMR Characterization of the Two Uncommon Polymorphs of Curcumin
Dai, Y., Terskikh, V. V., Brinkmann, A., & Wu, G. (2020) · Crystal Growth & Design · doi:10.1021/acs.cgd.0c01164 · Cited by 20 · see citing works
Polyphenols and Their Biogenic Nano‐Formulations Targeting BACE1 as Anti‐Amyloid Therapies; Meeting the Challenges of Bioavailability, Safety, and Specificity for the Treatment of Alzheimer's Disease
Elawad, M. A., Ayaz, M., Mosa, O. F., Usman, A., Hamdoon, A. A. E., Almawash, S., Salim, L. H. M., Ahmed, A., & Elkhalifa, M. E. M. (2024) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202400525 · Cited by 20 · see citing works
Curcumin-loaded poly-ε-caprolactone nanoparticles show antioxidant and cytoprotective effects in the presence of reactive oxygen species
Prado-Audelo, M. L. D., Martinez, G. R., Martínez-López, V., Ortega-Sánchez, C., Velasquillo, C., Magaña, J. J., González‐Torres, M., David, Q.-G., Sánchez‐Sánchez, R., & Leyva‐Gómez, G. (2020) · Journal of Bioactive and Compatible Polymers · doi:10.1177/0883911520921499 · Cited by 19 · see citing works
Self-citation
Curcumin Protects Human Umbilical Vein Endothelial Cells against H2O2-Induced Cell Injury
Ouyang, J., Li, R., Shi, H., & Jian-ping, Z. (2019) · Pain Research and Management · doi:10.1155/2019/3173149 · Cited by 18 · see citing works
“In addition, lots of researches showed that nanocarriers including liposomes, isomerization, polymeric nanoparticles, and polymeric micelles rendered a larger effect size for curcumin [32, 33].”
Background
Exploring the molecular mechanisms of curcumin in modulating memory impairment in neurodegenerative disorders
Baghcheghi, Y., Razazpour, F., Mirzaee, F., Dalfardi, M., Pourfridoni, M., & Hedayati‐Moghadam, M. (2024) · Molecular Biology Reports · doi:10.1007/s11033-024-10115-5 · Cited by 17 · see citing works
Maytansinoids in cancer therapy: advancements in antibody–drug conjugates and nanotechnology-enhanced drug delivery systems
Perra, M., Castangia, I., Aroffu, M., Fulgheri, F., Rached, R. A., Manca, M. L., Cortés, H., Prado-Audelo, M. L. D., Nomura-Contreras, C. A., Romero‐Montero, A., et al. (2025) · Discover Oncology · doi:10.1007/s12672-025-01820-z · Cited by 16 · see citing works
Self-citation
Study of anti-inflammatory and anti-arthritic potential of curcumin-loaded Eudragit L100 and hydroxy propyl methyl cellulose (HPMC) microparticles
Rajpoot, S. R., Ahmad, K., Asif, H. M., Madni, A., Tasleem, M. W., Zafar, F., Majeed, H., Khalid, A., Hashmi, H. A. S., Aslam, M. R., et al. (2023) · Polymer Bulletin · doi:10.1007/s00289-023-04899-y · Cited by 16 · see citing works
In vitro therapeutic evaluation of nanoliposome loaded with Xyloglucans polysaccharides from Tamarindus flower extract
Govindappa, M., Birawat, R., Akshatha, K., Raghavendra, V. B., Uzma, M., Ningaraju, S., Al-Rashed, S. A., Chowdappa, S., & Pugazhendhi, A. (2021) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2021.02.140 · Cited by 16 · see citing works
Anti-inflammatory effect of curcumin on neurological disorders: a narrative review
Zhou, B., & Hu, B. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1658115 · Cited by 15 · see citing works
Nanomedicine: Pioneering Advances in Neural Disease, Stroke and Spinal Cord Injury Treatment
Loushambam, B., Yanglem, S., Krishnaswami, V., Kumar, M., & Vijayaraghavalu, S. (2025) · Neuroglia · doi:10.3390/neuroglia6010009 · Cited by 14 · see citing works
“NLCs have been explored for their capacity to encapsulate curcumin to curtail the inflammation and oxidative damage resulting from PD [35].”
Synthesis of New Water Soluble β-Cyclodextrin@Curcumin Conjugates and In Vitro Safety Evaluation in Primary Cultures of Rat Cortical Neurons
Mihoub, A. B., Acherar, S., Frochot, C., Malaplate, C., Yen, F. T., & Arab‐Tehrany, E. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22063255 · Cited by 14 · see citing works
“CDs (α-, β-, and δ-CD) are a family of nat ral gluc pyranose-based cyclic oligosaccharides, with hydrophobic i ternal and hydrophilic external surfac s by the exposure of hydroxyl units [10].”
Background
Exploring the protective effect exhibited by curcumin-loaded coconut oil microemulsion in the experimental models of neurodegeneration: an insight of formulation development, in vitro and in vivo study
Patil, V., Mhamane, S., More, S., Pawar, A., & Arulmozhi, S. (2022) · Future Journal of Pharmaceutical Sciences · doi:10.1186/s43094-022-00441-5 · Cited by 14 · see citing works
Advances in Alzheimer’s disease therapeutics: biochemistry, exploring bioactive compounds and novel approaches
Atoki, A. V., Aja, P. M., Ondari, E. N., & Shinkafi, T. S. (2023) · International Journal of Food Properties · doi:10.1080/10942912.2023.2243050 · Cited by 19 · see citing works
Study on condition of ultrasound-assisted thermo-alkali-modified peanut protein embedding curcumin for nanoparticles
Li, W., Shi, Y., Hu, Y., Xu, N., Li, D., Wang, C., & Li, D. (2019) · Journal of Food Science and Technology · doi:10.1007/s13197-019-04139-0 · Cited by 14 · see citing works
“…groups to total sulfhydryl groups increased significantly under extreme alkaline (pH[ 10) conditions (P\ 0.05), which made the tertiary structure of soybean protein highly unfolded and helped the dissociation of the active group of protein molecule (Wang and Jiang 2012; Mehdi et al. 2017).”
BackgroundInfluential
Nutraceuticals and their Derived Nano-Formulations for the Prevention and Treatment of Alzheimer's Disease
Haque, S. E., Iqubal, A., Iqubal, M. K., Fazal, S. A., & Pottoo, F. H. (2021) · Current Molecular Pharmacology · doi:10.2174/1874467214666210309115605 · Cited by 14 · see citing works
Bio-MOF-Polymeric Hybrid Wound Healing Patch for Enhanced Transdermal Codelivery of Curcumin and Heparin
Pandya, I., Joshi, V., Kuddushi, M., Zhang, X., Kumar, S., Aswal, V. K., Raje, N. H., & Malek, N. I. (2025) · ACS Applied Engineering Materials · doi:10.1021/acsaenm.5c00246 · Cited by 13 · see citing works
Phytonutrients and Technological Development in Formulations
Jahangir, M. A. (2022) · doi:10.31531/jprst.1000159 · Cited by 13 · see citing works
Can Polyherbal Medicine be used for the Treatment of Diabetes? - A Review of Historical Classics, Research Evidence and Current Prevention Programs
Brahma, S., Goyal, A. K., Prakash, D., Kumari, M. R., Sadasivam, J., Usha, T., & Middha, S. K. (2023) · Current Diabetes Reviews · doi:10.2174/1573399819666230314093721 · Cited by 13 · see citing works
Polyphenol‐Based Assembly Nanosystems as Multifunctional Biopharmaceutical Platform
Jiang, X. Y., Zhang, J., Lo, P. K., & Mao, Z. (2023) · Advanced NanoBiomed Research · doi:10.1002/anbr.202200168 · Cited by 12 · see citing works
PEG 400:Trehalose Coating Enhances Curcumin-Loaded PLGA Nanoparticle Internalization in Neuronal Cells
Caballero-Florán, I. H., Cortés, H., Borbolla‐Jiménez, F. V., Florán-Hernández, C. D., Prado-Audelo, M. L. D., Magaña, J. J., Florán, B., & Leyva‐Gómez, G. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15061594 · Cited by 12 · see citing works
Self-citation
Curcumin encapsulated in PAMAM dendrimers for the therapeutic treatment of ischemic stroke in rats
Stadler, J., Garmo, L., Doyle, D., Cheng, C.-I., Richardson, G., Waheed, Z., Tofan, T., Srinageshwar, B., Sharma, A., Petersen, R., et al. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1467417 · Cited by 13 · see citing works
Curcumin and Its Nanoformulations as Therapeutic for Alzheimer’s Disease
Kakkar, V., Kumari, P., Adlakha, S., & Kaur, I. P. (2019) · Springer eBooks · doi:10.1007/978-3-030-30930-5_14 · Cited by 12 · see citing works
New Approaches for the Discovery of Pharmacologically-Active Natural Compounds
Medina‐Franco, J. L. (2019) · Biomolecules · doi:10.3390/biom9030115 · Cited by 12 · see citing works
Phytochemical Nanoparticles for the Treatment of Neurological Disorders
Ehtezazi, T., & Sarker, S. D. (2025) · Phytochemical Analysis · doi:10.1002/pca.70020 · Cited by 12 · see citing works
“NPs can be used as a carrier to deliver small hydrophilic molecules such as curcumin to the brain [86, 87].”
Curcumin Nanoparticles-related Non-invasive Tumor Therapy, and Cardiotoxicity Relieve
Cheng, Y., Xu, Q., Yu, M., Dang, C., Deng, L., & Chen, H. (2024) · Current Medicinal Chemistry · doi:10.2174/0109298673305616240610153554 · Cited by 11 · see citing works
GINGER LOADED CHITOSAN NANOPARTICLES FOR THE MANAGEMENT OF 3–NITROPROPIONIC ACID-INDUCED HUNTINGTON’S DISEASE-LIKE SYMPTOMS IN MALE WISTAR RATS
AKILA, R. M., & SHAJI, D. M. (2022) · International Journal of Pharmacy and Pharmaceutical Sciences · doi:10.22159/ijpps.2022v14i1.42894 · Cited by 11 · see citing works
“Some of the reported research on chitosan as a nano vehicle indicate that chitosan-based formulations are suitable systems for targeted drug delivery to the brain [7, 8].”
Background

Curcumin-loaded nanoparticles: a novel therapeutic strategy in treatment of central nervous system disorders
Yavarpour‐Bali, H., Ghasemi‐Kasman, M., & Pirzadeh, M. (2019) · International Journal of Nanomedicine · doi:10.2147/ijn.s208332 · Cited by 367 · see citing works
Pharmaceutical Applications of Curcumin-Loaded Nanoparticles
Rai, M., Pandit, R., Paralikar, P., Nagaonkar, D., Rehman, F., & dos Santos, C. A. (2017) · Springer eBooks · doi:10.1007/978-3-319-70299-5_6 · Cited by 10 · see citing works
Nano Encapsulated Curcumin: And Its Potential for Biomedical Applications
Chen, Y., Lu, Y., Lee, R. J., & Xiang, G. (2020) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 8 · see citing works
Transformation of Curcumin from Food Additive to Multifunctional Medicine: Nanotechnology Bridging the Gap
Ahmad, M. Z., Akhter, S., Mohsin, N., Abdel‐Wahab, B. A., Ahmad, J., Warsi, M. H., Rahman, M., Mallick, N., & Ahmad, F. J. (2014) · Current Drug Discovery Technologies · doi:10.2174/1570163811666140616153436 · Cited by 45 · see citing works
Curcumin Nano Drug Delivery Systems: A Review on its Type and Therapeutic Application
Dhivya, D., & Rajalakshmi, A. N. (2017) · Pharmatutor · doi:10.29161/pt.v5.i12.2017.30 · Cited by 8 · see citing works

Authors: Del Prado-Audelo, M. L., Caballero-Florán, I. H., Meza-Toledo, J. A., Mendoza-Muñoz, N., González-Torres, M., Florán, B., Cortés, H., & Leyva-Gómez, G.
Affiliations: Laboratorio de Posgrado en Tecnología Farmacéutica, FES-Cuautitlán, Universidad Nacional Autónoma de México, Cuautitlán Izcalli 54740, Mexico
Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (MX)
Universidad del Valle de México (MX)
Facultad de Ciencias Químicas, Universidad de Colima, C.P. Colima 28400, México
CONACyT-Laboratorio de Biotecnología, Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra, Ciudad de México 14389, Mexico
Departamento de Fisiología, Biofísica & Neurociencias, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Ciudad de México 07360, Mexico
Instituto Nacional de Rehabilitación (MX)
Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria, Circuito Exterior S/N, Del. Coyoacán, C.P. Ciudad de México 04510, Mexico
Corresponding author: Cortés, Hernán
ORCID: Caballero-Florán, Isaac H.
Mendoza-Muñoz, Néstor
González-Torres, Maykel
Florán, Benjamín
Cortés, Hernán
Venue: Biomolecules
Publisher: MDPI AG
Published: 2019-02-08
Volume: 9
Issue: 2
Pages: 56
ISSN: 2218-273X (ISSN-L)
DOI: 10.3390/biom9020056
PMC: PMC6406762
OpenAlex: W2913877945
Cited by: 191
References: 129
Citations by year: 2026: 18 · 2025: 28 · 2024: 22 · 2023: 30 · 2022: 26 · 2021: 35 · 2020: 21 · 2019: 11
FWCI: 1.54
Type: journal article
Language: en
Open access: gold
dx.doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Biomolecules (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: Dirección General de Asuntos del Personal Académico, Universidad Nacional Autónoma de México (PAPIIT TA 200318)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Curcumin's Biomedical Applications
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Keywords: curcumin, curcumin nanoparticles, brain disorders, nanoparticle drug delivery, bioavailability, water solubility, anti-inflammatory activity, antioxidant activity, polyphenols, neurodegenerative diseases
MeSH terms: Animals, Anti-Inflammatory Agents, Non-Steroidal, Brain Diseases, Curcumin, Humans, Temperature, Molecular Structure, Curcuma, Nanoparticles

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Formulations of Curcumin Nanoparticles for Brain Diseases

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks