Galantamine-loaded solid–lipid nanoparticles for enhanced brain delivery: preparation, characterization, in vitro and in vivo evaluations
Open accessAbstract
Galantamine hydrobromide, a promising acetylcholinesterase inhibitor is reported to be associated with cholinergic side effects. Its poor brain penetration results in lower bioavailability to the target site. With an aim to overcome these limitations, solid-lipid nanoparticulate formulation of galantamine hydrobromide was developed employing biodegradable and biocompatible components. The selected galantamine hydrobromide-loaded solid-lipid nanoparticles offered nanocolloidal with size lower than 100 nm and maximum drug entrapment 83.42 ± 0.63%. In vitro drug release from these spherical drug-loaded nanoparticles was observed to be greater than 90% for a period of 24 h in controlled manner. In vivo evaluations demonstrated significant memory restoration capability in cognitive deficit rats in comparison with naive drug. The developed carriers offered approximately twice bioavailability to that of plain drug. Hence, the galantamine hydrobromide-loaded solid-lipid nanoparticles can be a promising vehicle for safe and effective delivery especially in disease like Alzheimer's.
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Maximum drug entrapment of galantamine SLNs was ~83%, with greater than 90% drug release in 24 h.
“The maximum drug entrapment of these SLNs was ~83 %, with greater than 90% drug release in 24 h.”
From Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles (2019) · cites this paper as [104]
SLNs loaded with galantamine hydrobromide demonstrated enhanced bioavailability (two times higher than pure drug) and improved memory and cognition in animals.
“Interestingly, SLNs loaded with galantamine hydrobromide demonstrated enhanced bioavailability (two times higher than that of the pure drug) and improved memory and cognition in animals.104”
From Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles (2019) · cites this paper as [104]
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- Authors
- Misra, S., Chopra, K., Sinha, V. R., & Medhi, B.
- Affiliations
- Post Graduate Institute of Medical Education and Research (IN)
- Panjab University (IN)
- Corresponding author
- Medhi, Bikash
- Venue
- Drug Delivery
- Publisher
- Informa UK Limited
- Published
- 2015-09-25
- Volume
- 23
- Issue
- 4
- Pages
- 1434-1443
- ISSN
- 1071-7544 (ISSN-L)
- 1521-0464
- OpenAlex
- W1867774233
- Cited by
- 136
- References
- 40
- Citations by year
- 2026: 12 · 2025: 14 · 2024: 11 · 2023: 19 · 2022: 29 · 2021: 10 · 2020: 16 · 2019: 9 · 2018: 7 · 2017: 6 · 2016: 3
- FWCI
- 2.96
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Drug Delivery (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Sun Pharma
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
- Keywords
- galantamine hydrobromide, solid lipid nanoparticles, brain drug delivery, acetylcholinesterase inhibitors, Alzheimer's disease, encapsulation efficiency, controlled drug release, cognitive impairment, bioavailability enhancement, nanocarriers
- MeSH terms
- Animals, Brain, Cholinesterase Inhibitors, Drug Carriers, Galantamine, Lipids, Drug Delivery Systems, Rats, Nanoparticles
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