Manufactured nanoparticles: their uptake and effects on fish—a mechanistic analysis

Handy, Richard D.; Henry, Theodore B.; Scown, Tessa M.; Johnston, Blair D.; Tyler, Charles R.

doi:10.1007/s10646-008-0205-1

Cited by 447Environmental Toxicology and EcotoxicologyNanoparticles: synthesis and applicationsImmunotoxicology and immune responses

Manufactured nanoparticles: their uptake and effects on fish—a mechanistic analysis

Handy, Richard D., Henry, Theodore B., Scown, Tessa M., Johnston, Blair D., Tyler, Charles R.·2008·Ecotoxicology

DOI 10.1007/s10646-008-0205-1

Open this paper in CoChat — free account

Abstract

There is an emerging literature reporting toxic effects of manufactured nanomaterials (NMs) and nanoparticles (NPs) in fish, but the mechanistic basis of both exposure and effect are poorly understood. This paper critically evaluates some of the founding assumptions in fish toxicology, and likely mechanisms of absorption, distribution, metabolism and excretion (ADME) of NPs in fish compared to other chemicals. Then, using a case study approach, the paper compares these assumptions for two different NPs; TiO2 and C60 fullerenes. Adsorption of NPs onto the gill surface will involve similar processes in the gill microenvironment and mucus layer to other substances, but the uptake mechanisms for NPs by epithelial cells are more likely to occur via vesicular processes (e.g., endocytosis) than uptake on membrane transporters or by diffusion through the cell membranes. Target organs may include the gills, gut, liver and sometimes the brain. Information on metabolism and excretion of NPs in fish is limited; but hepatic excretion into the bile seems a more likely mechanism, rather than mainly by renal or branchial excretion. TiO2 and C60 share some common chemical properties that appear to be associated with some similar toxic effects, but there are also differences, that highlight the notion that chemical reactivity can inform toxic effect of NPs in a fundamentally similar way to other chemicals. In this paper we identify many knowledge gaps including the lack of field observations on fish and other wildlife species for exposure and effects of manufactured NMs. Systematic studies of the abiotic factors that influence bioavailability, and investigation of the cell biology that informs on the mechanisms of metabolism and excretion of NMs, will greatly advance our understanding of the potential for adverse effects. There are also opportunities to apply existing tools and techniques to fundamental studies of fish toxicology with NPs, such as perfused organs and fish cell culture systems.

Integrity signals

Registry

Crossref · 10.1007/s10646-008-0205-1

Cites

72 of 72 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Mechanisms of translocation have been proposed for micro- and nanoplastic particles, including by vesicular processes such as endocytosis by enterocytes.
“Mechanisms of translocation have been proposed for micro- and nanoplastic particles, including by vesicular processes, such as endocytosis19 by enterocytes.20”
From Microplastics and Anthropogenic Particles in Recreationally Caught Freshwater Fish from an Urbanized Region of the North American Great Lakes (2024) · cites this paper as [19]

Helical microtubules of graphitic carbon
Iijima, S. (1991) · Nature · doi:10.1038/354056a0 · Cited by 43,126 · see citing works
C60: Buckminsterfullerene
Kroto, H. W., Heath, J. R., O’Brien, S. C., Curl, R. F., & Smalley, R. E. (1985) · Nature · doi:10.1038/318162a0 · Cited by 16,169 · see citing works
The potential environmental impact of engineered nanomaterials
Colvin, V. L. (2003) · Nature Biotechnology · doi:10.1038/nbt875 · Cited by 2,161 · see citing works
Manufactured Nanomaterials (Fullerenes, C60) Induce Oxidative Stress in the Brain of Juvenile Largemouth Bass
Oberdörster, E. (2004) · Environmental Health Perspectives · doi:10.1289/ehp.7021 · Cited by 1,393 · see citing works
Do nanoparticles present ecotoxicological risks for the health of the aquatic environment?
Moore, M. N. (2006) · Environment International · doi:10.1016/j.envint.2006.06.014 · Cited by 1,255 · see citing works
Photophysical properties of sixty atom carbon molecule (C60)
Arbogast, J. W., Darmanyan, A. P., Foote, C. S., Diederich, F., Whetten, R. L., Rubin, Y. F., Alvarez, M. M., & Anz, S. J. (1991) · The Journal of Physical Chemistry · doi:10.1021/j100154a006 · Cited by 1,213 · see citing works
Particle Deposition and Aggregation: Measurement, Modelling and Simulation
Elimelech, M. (1995) · Cited by 1,190 · see citing works
Acute toxicity and biodistribution of different sized titanium dioxide particles in mice after oral administration
Wang, J., Zhou, G.-D., Chen, C., YU, H., WANG, T., Ma, Y., JIA, G., Gao, Y., Li, B., & SUN, J. (2006) · Toxicology Letters · doi:10.1016/j.toxlet.2006.12.001 · Cited by 1,145 · see citing works
The Differential Cytotoxicity of Water-Soluble Fullerenes
Sayes, C. M., Fortner, J. D., Guo, W., Lyon, D. Y., Boyd, A. M., Ausman, K. D., Tao, Y. J., Sitharaman, B., Wilson, L. J., Hughes, J. B., et al. (2004) · Nano Letters · doi:10.1021/nl0489586 · Cited by 1,090 · see citing works
Carbon nanotubes show no sign of acute toxicity but induce intracellular reactive oxygen species in dependence on contaminants
Pulskamp, K., Diabaté, S., & Krug, H. F. (2006) · Toxicology Letters · doi:10.1016/j.toxlet.2006.11.001 · Cited by 1,003 · see citing works
The ecotoxicology and chemistry of manufactured nanoparticles
Handy, R. D., von der Kammer, F., Lead, J. R., Hassellöv, M., Owen, R., & Crane, M. (2008) · Ecotoxicology · doi:10.1007/s10646-008-0199-8 · Cited by 916 · see citing works
Self-citation
The ecotoxicology of nanoparticles and nanomaterials: current status, knowledge gaps, challenges, and future needs
Handy, R. D., Owen, R., & Valsami‐Jones, E. (2008) · Ecotoxicology · doi:10.1007/s10646-008-0206-0 · Cited by 890 · see citing works
Self-citation
Toxicity of titanium dioxide nanoparticles to rainbow trout (Oncorhynchus mykiss): Gill injury, oxidative stress, and other physiological effects
Federici, G., Shaw, B. J., & Handy, R. D. (2007) · Aquatic Toxicology · doi:10.1016/j.aquatox.2007.07.009 · Cited by 821 · see citing works
Self-citation
Adsorption of Polycyclic Aromatic Hydrocarbons by Carbon Nanomaterials
Yang, K., Zhu, L., & Xing, B. (2006) · Environmental Science & Technology · doi:10.1021/es052208w · Cited by 774 · see citing works
Nanotechnology: convergence with modern biology and medicine
Roco, M. C. (2003) · Current Opinion in Biotechnology · doi:10.1016/s0958-1669(03)00068-5 · Cited by 764 · see citing works
The biotic ligand model: a historical overview
Paquin, P. R., Gorsuch, J. W., Apte, S. C., Batley, G. E., Bowles, K. C., Campbell, P. G. C., Delos, C. G., Toro, D. M. D., Dwyer, R., Gálvez-Montosa, F., et al. (2002) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/s1532-0456(02)00112-6 · Cited by 741 · see citing works
Nanoparticles: structure, properties, preparation and behaviour in environmental media
Christian, P. W. N., von der Kammer, F., Baalousha, M., & Hofmann, T. (2008) · Ecotoxicology · doi:10.1007/s10646-008-0213-1 · Cited by 713 · see citing works
Nano-C60 cytotoxicity is due to lipid peroxidation
Sayes, C. M., Gobin, A. M., Ausman, K. D., Mendez, J. S., West, J. L., & Colvin, V. L. (2005) · Biomaterials · doi:10.1016/j.biomaterials.2005.05.027 · Cited by 687 · see citing works
C60 in Water: Nanocrystal Formation and Microbial Response
Fortner, J. D., Lyon, D. Y., Sayes, C. M., Boyd, A. M., Falkner, J. C., Hotze, E. M., Alemany, L. B., Tao, Y. J., Guo, W., Ausman, K. D., et al. (2005) · Environmental Science & Technology · doi:10.1021/es048099n · Cited by 667 · see citing works
Pulmonary Responses of Mice, Rats, and Hamsters to Subchronic Inhalation of Ultrafine Titanium Dioxide Particles
Bermudez, E., Mangum, J. B., Wong, B. A., Asgharian, B., Hext, P. M., Warheit, D. B., & Everitt, J. I. (2004) · Toxicological Sciences · doi:10.1093/toxsci/kfh019 · Cited by 652 · see citing works
Pulmonary toxicity study in rats with three forms of ultrafine-TiO2 particles: Differential responses related to surface properties
Warheit, D. B., Webb, T. R., Reed, K. L., Frerichs, S., & Sayes, C. M. (2006) · Toxicology · doi:10.1016/j.tox.2006.11.002 · Cited by 645 · see citing works
Manufacture and use of nanomaterials: current status in the UK and global trends
Aitken, R. J., Chaudhry, M. Q., Boxall, A. B. A., & Hull, M. S. (2006) · Occupational Medicine · doi:10.1093/occmed/kql051 · Cited by 638 · see citing works
Toxicity of single walled carbon nanotubes to rainbow trout, (Oncorhynchus mykiss): Respiratory toxicity, organ pathologies, and other physiological effects
SMITH, C., Shaw, B. J., & Handy, R. D. (2007) · Aquatic Toxicology · doi:10.1016/j.aquatox.2007.02.003 · Cited by 618 · see citing works
Self-citation
Daphnia magna mortality when exposed to titanium dioxide and fullerene (C60) nanoparticles
Lovern, S. B., & Klaper, R. D. (2006) · Environmental Toxicology and Chemistry · doi:10.1897/05-278r.1 · Cited by 600 · see citing works
Exposure to Copper Nanoparticles Causes Gill Injury and Acute Lethality in Zebrafish ( Danio rerio )
Griffitt, R. J., Weil, R. E., Hyndman, K. A., Denslow, N. D., Powers, K. W., Taylor, D., & Barber, D. S. (2007) · Environmental Science & Technology · doi:10.1021/es071235e · Cited by 593 · see citing works
Photocatalytic activity and photoinduced hydrophilicity of titanium dioxide coated glass
Watanabe, T., Nakajima, A., Wang, R., Minabe, M., Koizumi, S., Fujishima, A., & Hashimoto, K. (1999) · Thin Solid Films · doi:10.1016/s0040-6090(99)00205-9 · Cited by 586 · see citing works
Direct and indirect effects of single walled carbon nanotubes on RAW 264.7 macrophages: Role of iron
Kagan, V. E., Tyurina, Y. Y., Tyurin, V. A., Konduru, N. V., Potapovich, A. I., Osipov, A. N., Kisin, E. R., Schwegler‐Berry, D., Mercer, R. R., Castranova, V., et al. (2006) · Toxicology Letters · doi:10.1016/j.toxlet.2006.02.001 · Cited by 560 · see citing works
Aquatic Colloids and Nanoparticles: Current Knowledge and Future Trends
Lead, J. R., & Wilkinson, K. J. (2006) · Environmental Chemistry · doi:10.1071/en06025 · Cited by 526 · see citing works
Distribution of Nanoparticles in the See-through Medaka ( Oryzias latipes )
Kashiwada, S. (2006) · Environmental Health Perspectives · doi:10.1289/ehp.9209 · Cited by 524 · see citing works
Role of the alveolar macrophage in lung injury: studies with ultrafine particles.
Oberdörster, G., Ferin, J., Gelein, R. M., Soderholm, S. C., & Finkelstein, J. N. (1992) · Environmental Health Perspectives · doi:10.1289/ehp.97-1519541 · Cited by 515 · see citing works
Pulmonary Instillation Studies with Nanoscale TiO2 Rods and Dots in Rats: Toxicity Is not Dependent upon Particle Size and Surface Area
Warheit, D. B., Webb, T. R., Sayes, C. M., Colvin, V. L., & Reed, K. L. (2006) · Toxicological Sciences · doi:10.1093/toxsci/kfj140 · Cited by 508 · see citing works
Ecotoxicology of carbon-based engineered nanoparticles: Effects of fullerene (C60) on aquatic organisms
Oberdörster, E., Zhu, S., Blickley, T. M., McClellan‐Green, P. D., & Haasch, M. L. (2005) · Carbon · doi:10.1016/j.carbon.2005.11.008 · Cited by 506 · see citing works
A review of non-DLVO interactions in environmental colloidal systems
Grasso*, D., Subramaniam, K., Butkus, M., Strevett, K. A., & Bergendahl, J. (2002) · Reviews in Environmental Science and Bio/Technology · doi:10.1023/a:1015146710500 · Cited by 468 · see citing works
Toxicity of an engineered nanoparticle (fullerene, C60) in two aquatic species, Daphnia and fathead minnow
Zhu, S., Oberdörster, E., & Haasch, M. L. (2006) · Marine Environmental Research · doi:10.1016/j.marenvres.2006.04.059 · Cited by 417 · see citing works
Toxic effects of nanoparticles and nanomaterials: Implications for public health, risk assessment and the public perception of nanotechnology
Handy, R. D., & Shaw, B. J. (2007) · Health Risk & Society · doi:10.1080/13698570701306807 · Cited by 394 · see citing works
Self-citation
Effect of carbon nanotubes on developing zebrafish ( Danio Rerio ) embryos
Cheng, J., Flahaut, E., & Cheng, S. H. (2007) · Environmental Toxicology and Chemistry · doi:10.1897/06-272r.1 · Cited by 391 · see citing works
The in vitro absorption of microfine zinc oxide and titanium dioxide through porcine skin
Gamer, A. O., Leibold, E., & van Ravenzwaay, B. (2005) · Toxicology in Vitro · doi:10.1016/j.tiv.2005.08.008 · Cited by 342 · see citing works
Attributing Effects of Aqueous C60 Nano-Aggregates to Tetrahydrofuran Decomposition Products in Larval Zebrafish by Assessment of Gene Expression
Henry, T. B., Menn, F., Fleming, J. T., Wilgus, J. R., Compton, R. N., & Sayler, G. S. (2007) · Environmental Health Perspectives · doi:10.1289/ehp.9757 · Cited by 257 · see citing works
Self-citation
SIGNIFICANCE OF PARTICLE PARAMETERS IN THE EVALUATION OF EXPOSURE-DOSE RESPONSE RELATIONSHIPS OF INHALED PARTICLES
Oberdörster, G. (1996) · Particulate Science And Technology · doi:10.1080/02726359608906690 · Cited by 241 · see citing works
Significance of particle parameters in the evaluation of exposure-dose-response relationships of inhaled particles.
Oberdörster, G. (1996) · PubMed · Cited by 227 · see citing works
Comparative Pulmonary Toxicity Inhalation and Instillation Studies with Different TiO2 Particle Formulations: Impact of Surface Treatments on Particle Toxicity
Warheit, D. B., Brock, W. J., Lee, K. P., Webb, T., & Reed, K. L. (2005) · Toxicological Sciences · doi:10.1093/toxsci/kfi331 · Cited by 222 · see citing works
Developmental toxicity in zebrafish (Danio rerio) embryos after exposure to manufactured nanomaterials: Buckminsterfullerene aggregates (nC60) and fullerol
Zhu, X., Zhu, L., Li, Y., Duan, Z., Chen, W., & Alvarez, P. J. J. (2007) · Environmental Toxicology and Chemistry · doi:10.1897/06-583.1 · Cited by 212 · see citing works
The effects of pH and calcium concentrations on gill potentials in the Brown Trout,Salmo trutta
McWilliams, P. G., & Potts, W. T. W. (1978) · Journal of Comparative Physiology B · doi:10.1007/bf00688938 · Cited by 197 · see citing works
Single-Walled Carbon Nanotubes Induces Oxidative Stress in Rat Lung Epithelial Cells
Sharma, C. S., Sarkar, S., Periyakaruppan, A., Barr, J. L., WISE, K. C., THOMAS, R. L., Wilson, B. L., & Ramesh, G. T. (2007) · Journal of Nanoscience and Nanotechnology · doi:10.1166/jnn.2007.431 · Cited by 175 · see citing works
Concepts of Nanoparticle Dose Metric and Response Metric
Oberdörster, G., Oberdörster, E., & Oberdörster, J. (2007) · Environmental Health Perspectives · doi:10.1289/ehp.115-a290a · Cited by 173 · see citing works
Photochemical Production of Reactive Oxygen Species by C60in the Aqueous Phase During UV Irradiation
Lee, J., Fortner, J. D., Hughes, J. B., & Kim, J. (2007) · Environmental Science & Technology · doi:10.1021/es062066l · Cited by 163 · see citing works
Concepts of Nanoparticle Dose Metric and Response Metric
Oberdörster, G., Oberdörster, E., & Oberdörster, J. (2007) · Environmental Health Perspectives · doi:10.1289/ehp.115-1892118 · Cited by 157 · see citing works
•OH and O2•- Generation in Aqueous C60 and C70 Solutions by Photoirradiation: An EPR Study
Yamakoshi, Y., Sueyoshi, S., Fukuhara, K., Miyata, N., Masumizu, T., & Kohno, M. (1998) · Journal of the American Chemical Society · doi:10.1021/ja9823969 · Cited by 157 · see citing works
Studies of aqueous colloidal solutions of fullerene C60 by electron microscopy
Andrievsky, G. V., Klochkov, V., Karyakina, E. L., & Mchedlov‐Petrossyan, N. O. (1999) · Chemical Physics Letters · doi:10.1016/s0009-2614(98)01393-1 · Cited by 153 · see citing works
Changes in size distribution of fresh water nanoscale colloidal matter and associated elements on mixing with seawater
Stolpe, B., & Hassellöv, M. (2007) · Geochimica et Cosmochimica Acta · doi:10.1016/j.gca.2007.04.025 · Cited by 151 · see citing works
Viewpoint: Formulating the Problems for Environmental Risk Assessment of Nanomaterials
HANDY, R. O. A. R. (2007) · Environmental Science & Technology · doi:10.1021/es072598h · Cited by 144 · see citing works
Self-citation
A model for exchange of organic chemicals at fish gills: flow and diffusion limitations
Erickson, R. J., & McKim, J. M. (1990) · Aquatic Toxicology · doi:10.1016/0166-445x(90)90001-6 · Cited by 125 · see citing works
Pharmacokinetics of a water-soluble fullerene in rats
Rajagopalan, P., Wudl, F., Schinazi, R. F., & Boudinot, F. D. (1996) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.40.10.2262 · Cited by 124 · see citing works
Cultured gill epithelia as models for the freshwater fish gill
Wood, C. M., Kelly, S. P., Zhou, B., Fletcher, M., O'Donnell, M., Eletti, B., & Pärt, P. (2002) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(02)00595-3 · Cited by 104 · see citing works
Mechanisms of Gastrointestinal Copper Absorption in the African Walking Catfish: Copper Dose-Effects and a Novel Anion-Dependent Pathway in the Intestine
Handy, R. D., Makasa, M., Phillips, C., & Falla, S. J. (2000) · Journal of Experimental Biology · doi:10.1242/jeb.203.15.2365 · Cited by 103 · see citing works
Self-citation
Adsorption behavior of copper and cyanide ions at TiO2–solution interface
Barakat, M. A. E.-F. (2005) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2005.05.047 · Cited by 93 · see citing works
Functional units in rainbow trout (Salmo gairdneri, Richardson) liver: II. The biliary system
Hampton, J. A., Lantz, R. C., Goldblatt, P. J., Laurén, D. J., & Hinton, D. E. (1988) · The Anatomical Record · doi:10.1002/ar.1092210208 · Cited by 83 · see citing works
Solubilisation of C60 in aqueous micellar solution
Beeby, A., Eastoe, J., & Heenan, R. K. (1994) · Journal of the Chemical Society Chemical Communications · doi:10.1039/c39940000173 · Cited by 77 · see citing works
Fine particles that adsorb lipopolysaccharide via bridging calcium cations may mimic bacterial pathogenicity towards cells.
Ashwood, P., Thompson, R. P. H., & Powell, J. J. (2007) · PubMed · Cited by 72 · see citing works
Histological observations on intrahepatocytic copper-containing granules in rainbow trout reared on diets containing elevated levels of copper
Lanno, R. P., Hicks, B., & Hilton, J. W. (1987) · Aquatic Toxicology · doi:10.1016/0166-445x(87)90001-4 · Cited by 70 · see citing works
Nanoparticles and Nanolayers In Commercial Applications
Anselmann, R. (2001) · Journal of Nanoparticle Research · doi:10.1023/a:1017529712314 · Cited by 66 · see citing works
Effect of cortisol on the physiology of cultured pavement cell epithelia from freshwater trout gills
Kelly, S. P., & Wood, C. M. (2001) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2001.281.3.r811 · Cited by 59 · see citing works
Environmental particles. Vol. 1. (IUPAC Environmental analytical and physical chemistry series).
Buffle, J., & van Leeuwen, H. P. (1992) · Socio-Environmental Systems Modeling · Cited by 57 · see citing works
Effect of sonication on the photo-catalytic mineralization of some chlorinated organic compounds
Hirano, K., Nitta, H., & Sawada, K. (2004) · Ultrasonics Sonochemistry · doi:10.1016/j.ultsonch.2004.01.034 · Cited by 55 · see citing works
Copper uptake kinetics across the gills of rainbow trout (Oncorhynchus mykiss) measured using an improved isolated perfused head technique
Campbell, H. A., Handy, R. D., & Nimmo, M. (1999) · Aquatic Toxicology · doi:10.1016/s0166-445x(99)00003-x · Cited by 49 · see citing works
Self-citation
The development of osmotic flow through an unstirred layer
Pedley, T. J., & Fischbarg, J. (1978) · Journal of Theoretical Biology · doi:10.1016/0022-5193(78)90251-5 · Cited by 47 · see citing works
Uptake of 203Hg2+ in the olfactory system in pike
Borg‐Neczak, K., & Tjälve, H. (1996) · Toxicology Letters · doi:10.1016/0378-4274(95)03622-9 · Cited by 33 · see citing works
Transport of Solutes Across Biological Membranes in Eukaryotes: An Environmental Perspective
Handy, R. D., & Eddy, F. B. (2004) · doi:10.1002/0470094044.ch7 · Cited by 32 · see citing works
Self-citation
Effects of Inorganic Cations on Na+Adsorption to the Gill and Body Surface of Rainbow Trout,Oncorhynchus mykiss, in Dilute Solutions
Handy, R. D., & Eddy, F. B. (1991) · Canadian Journal of Fisheries and Aquatic Sciences · doi:10.1139/f91-216 · Cited by 29 · see citing works
Self-citation
Substrate access channel topology in membrane-bound prostacyclin synthase
Deng, H. Y., HUANG, A., So, S., Lin, Y.-Z., & Ruan, K. (2002) · Biochemical Journal · doi:10.1042/bj3620545 · Cited by 27 · see citing works
Reactive Species Responsible for Biological Actions of Photoexcited Fullerenes
Miyata, N., Yamakoshi, Y. N., & Nakanishi, I. (2000) · YAKUGAKU ZASSHI · doi:10.1248/yakushi1947.120.10_1007 · Cited by 21 · see citing works
SUNSCREENS AND COSMETICS CONTAINING MANGANESE DOPED TITANIUM OXIDE NANOPARTICLES
Wakefield, G., & Stott, J. (2005) · Cited by 14 · see citing works

Flagged first, then by citations

Sorted by citations

Plastic and Human Health: A Micro Issue?
Wright, S. L., & Kelly, F. J. (2017) · Environmental Science & Technology · doi:10.1021/acs.est.7b00423 · Cited by 3,413 · see citing works
Potential Health Impact of Environmentally Released Micro- and Nanoplastics in the Human Food Production Chain: Experiences from Nanotoxicology
Bouwmeester, H., Hollman, P. C. H., & Peters, R. (2015) · Environmental Science & Technology · doi:10.1021/acs.est.5b01090 · Cited by 1,275 · see citing works
Manufactured nanoparticles: An overview of their chemistry, interactions and potential environmental implications
Ju‐Nam, Y., & Lead, J. R. (2008) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2008.06.042 · Cited by 1,042 · see citing works
Presence of microplastics and nanoplastics in food, with particular focus on seafood
(CONTAM), E. P. O. C. I. T. F. C. (2016) · EFSA Journal · doi:10.2903/j.efsa.2016.4501 · Cited by 958 · see citing works
Microplastics in Wild Fish from North East Atlantic Ocean and Its Potential for Causing Neurotoxic Effects, Lipid Oxidative Damage, and Human Health Risks Associated with Ingestion Exposure
Barboza, L. G. A., Lopes, C., Oliveira, P., Bessa, F., Otero, V., Henriques, B., Raimundo, J., Caetano, M., Vale, C., & Guilhermino, L. (2020) · Science of The Total Environment · doi:10.1016/j.scitotenv.2019.134625 · Cited by 951 · see citing works
Micro(nano)plastics: A threat to human health?
Revel, M., Châtel, A., & Mouneyrac, C. (2017) · Current Opinion in Environmental Science & Health · doi:10.1016/j.coesh.2017.10.003 · Cited by 813 · see citing works
From ecotoxicology to nanoecotoxicology
Kahru, A., & Dubourguier, H. (2009) · Toxicology · doi:10.1016/j.tox.2009.08.016 · Cited by 793 · see citing works
Nanomaterials in the Construction Industry: A Review of Their Applications and Environmental Health and Safety Considerations
Lee, J., Mahendra, S., & Alvarez, P. J. J. (2010) · ACS Nano · doi:10.1021/nn100866w · Cited by 750 · see citing works
Toxicity of Engineered Nanoparticles in the Environment
Maurer‐Jones, M. A., Gunsolus, I. L., Murphy, C. J., & Haynes, C. L. (2013) · Analytical Chemistry · doi:10.1021/ac303636s · Cited by 734 · see citing works
Nanomaterials in the environment: Behavior, fate, bioavailability, and effects—An updated review
Lead, J. R., Batley, G. E., Alvarez, P. J. J., Croteau, M., Handy, R. D., McLaughlin, M. J., Judy, J. D., & Schirmer, K. (2018) · Environmental Toxicology and Chemistry · doi:10.1002/etc.4147 · Cited by 691 · see citing works
Self-citation
Nanoparticles: Their potential toxicity, waste and environmental management
Bystrzejewska-Piotrowska, G., Golimowski, J., & Urban, P. L. (2009) · Waste Management · doi:10.1016/j.wasman.2009.04.001 · Cited by 645 · see citing works
ROS-mediated genotoxicity induced by titanium dioxide nanoparticles in human epidermal cells
Shukla, R. K., Sharma, V., Pandey, A. K., Singh, S. S., Sultana, S., & Dhawan, A. (2010) · Toxicology in Vitro · doi:10.1016/j.tiv.2010.11.008 · Cited by 564 · see citing works
Ecotoxicity and analysis of nanomaterials in the aquatic environment
Farré, M., Gajda‐Schrantz, K., Kantiani, L., & Barceló, ‪. (2008) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-008-2458-1 · Cited by 504 · see citing works
Nanopesticides: Guiding Principles for Regulatory Evaluation of Environmental Risks
Kookana, R. S., Boxall, A. B. A., Reeves, P. T., Ashauer, R., Beulke, S., Chaudhry, Q., Cornelis, G., Fernandes, T. F., Gan, J. J., Kah, M., et al. (2014) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf500232f · Cited by 483 · see citing works
Physiological effects of nanoparticles on fish: A comparison of nanometals versus metal ions
Shaw, B. J., & Handy, R. D. (2011) · Environment International · doi:10.1016/j.envint.2011.03.009 · Cited by 408 · see citing works
Self-citation
Ecotoxicity of nanosized TiO2. Review of in vivo data
Menard, A., Drobne, D., & Kokalj, A. J. (2010) · Environmental Pollution · doi:10.1016/j.envpol.2010.11.027 · Cited by 403 · see citing works
Fate and Transport of Engineered Nanomaterials in the Environment
Lin, D., Tian, X., Wu, F., & Xing, B. (2010) · Journal of Environmental Quality · doi:10.2134/jeq2009.0423 · Cited by 377 · see citing works
New views on cellular uptake and trafficking of manufactured nanoparticles
Treuel, L., Jiang, X., & Nienhaus, G. U. (2013) · Journal of The Royal Society Interface · doi:10.1098/rsif.2012.0939 · Cited by 361 · see citing works
A review of the characteristics of nanoparticles in the urban atmosphere and the prospects for developing regulatory controls
Kumar, P., Robins, A. G., Vardoulakis, S., & Britter, R. E. (2010) · Atmospheric Environment · doi:10.1016/j.atmosenv.2010.08.016 · Cited by 352 · see citing works
Ecotoxicity test methods for engineered nanomaterials: Practical experiences and recommendations from the bench
Handy, R. D., Cornelis, G., Fernandes, T. F., Tsyusko, O. V., Decho, A. W., Sabo‐Attwood, T., Metcalfe, C. D., Steevens, J. A., Klaine, S. J., Koelmans, A. A., et al. (2011) · Environmental Toxicology and Chemistry · doi:10.1002/etc.706 · Cited by 345 · see citing works
Self-citation
Role of Physicochemical Properties in Nanoparticle Toxicity
Shin, S. W., Song, I. K., & Um, S. H. (2015) · Nanomaterials · doi:10.3390/nano5031351 · Cited by 345 · see citing works
Effects of Aqueous Exposure to Silver Nanoparticles of Different Sizes in Rainbow Trout
Scown, T. M., Santos, E. M., Johnston, B. D., Gaiser, B. K., Baalousha, M., Mitov, S., Lead, J. R., Stone, V., Fernandes, T. F., Jepson, M. A., et al. (2010) · Toxicological Sciences · doi:10.1093/toxsci/kfq076 · Cited by 341 · see citing works
Self-citation
Review: Do engineered nanoparticles pose a significant threat to the aquatic environment?
Scown, T. M., van Aerle, R., & Tyler, C. R. (2010) · Critical Reviews in Toxicology · doi:10.3109/10408444.2010.494174 · Cited by 332 · see citing works
Self-citation
Bioavailability of silver nanoparticles and ions: from a chemical and biochemical perspective
Behra, R., Sigg, L., Clift, M. J. D., Herzog, F., Minghetti, M., Johnston, B. D., Petri‐Fink, A., & Rothen‐Rutishauser, B. (2013) · Journal of The Royal Society Interface · doi:10.1098/rsif.2013.0396 · Cited by 329 · see citing works
Self-citation
Bioaccumulation and ecotoxicity of carbon nanotubes
Jackson, P., Jacobsen, N. R., Baun, A., Birkedal, R. K., Kühnel, D., Jensen, K. A., Vogel, U. B., & Wallin, H. (2013) · Chemistry Central Journal · doi:10.1186/1752-153x-7-154 · Cited by 322 · see citing works
Trophic transfer of TiO2 nanoparticles from daphnia to zebrafish in a simplified freshwater food chain
Zhu, X., Wang, J., Zhang, X., Chang, Y., & Chen, Y. (2010) · Chemosphere · doi:10.1016/j.chemosphere.2010.03.022 · Cited by 301 · see citing works
Evidence of Microplastic Translocation in Wild-Caught Fish and Implications for Microplastic Accumulation Dynamics in Food Webs
McIlwraith, H. K., Kim, J., Helm, P., Bhavsar, S. P., Metzger, J. S., & Rochman, C. M. (2021) · Environmental Science & Technology · doi:10.1021/acs.est.1c02922 · Cited by 295 · see citing works
Evaluation of the toxic impact of silver nanoparticles on Japanese medaka (Oryzias latipes)
Chae, Y. J., Pham, C. H., Lee, J., Bae, E., Yi, J., & Gu, M. B. (2009) · Aquatic Toxicology · doi:10.1016/j.aquatox.2009.07.019 · Cited by 285 · see citing works
Effect of sub-acute exposure to TiO2 nanoparticles on oxidative stress and histopathological changes in Juvenile Carp (Cyprinus carpio)
Hao, L., Wang, Z., & Xing, B. (2009) · Journal of Environmental Sciences · doi:10.1016/s1001-0742(08)62440-7 · Cited by 281 · see citing works
Toxic effects of engineered nanoparticles in the marine environment: Model organisms and molecular approaches
Matranga, V., & Corsi, I. (2012) · Marine Environmental Research · doi:10.1016/j.marenvres.2012.01.006 · Cited by 280 · see citing works
Review of Nanomaterials in Dentistry: Interactions with the Oral Microenvironment, Clinical Applications, Hazards, and Benefits
Besinis, A., de Peralta, T. L., Tredwin, C. J., & Handy, R. D. (2015) · ACS Nano · doi:10.1021/nn505015e · Cited by 274 · see citing works
Self-citation
Effects of microplastics and nanoplastics on marine environment and human health
Sana, S. S., Dogiparthi, L. K., Gangadhar, L., Chakravorty, A., & Abhishek, N. (2020) · Environmental science and pollution research international · doi:10.1007/s11356-020-10573-x · Cited by 203 · see citing works
Exploring uptake and biodistribution of polystyrene (nano)particles in zebrafish embryos at different developmental stages
van Pomeren, M., Brun, N. R., Peijnenburg, W. J. G. M., & Vijver, M. G. (2017) · Aquatic Toxicology · doi:10.1016/j.aquatox.2017.06.017 · Cited by 258 · see citing works
Biomarkers in Mytilus galloprovincialis exposed to suspensions of selected nanoparticles (Nano carbon black, C60 fullerene, Nano-TiO2, Nano-SiO2)
Canesi, L., Fabbri, R., Gallo, G., Vallotto, D., Marcomini, A., & Pojana, G. (2010) · Aquatic Toxicology · doi:10.1016/j.aquatox.2010.04.009 · Cited by 257 · see citing works
Carbon Quantum Dots for Zebrafish Fluorescence Imaging
Kang, Y., Li, Y., Fang, Y., Xu, Y., Wei, X.-M., & Yin, X. (2015) · Scientific Reports · doi:10.1038/srep11835 · Cited by 237 · see citing works
Dietary exposure to titanium dioxide nanoparticles in rainbow trout, (Oncorhynchus mykiss): no effect on growth, but subtle biochemical disturbances in the brain
Ramsden, C. S., Smith, T. J., Shaw, B. J., & Handy, R. D. (2009) · Ecotoxicology · doi:10.1007/s10646-009-0357-7 · Cited by 222 · see citing works
Self-citation
Effects of waterborne copper nanoparticles and copper sulphate on rainbow trout, (Oncorhynchus mykiss): Physiology and accumulation
Shaw, B. J., Al-Bairuty, G. A., & Handy, R. D. (2012) · Aquatic Toxicology · doi:10.1016/j.aquatox.2012.02.032 · Cited by 220 · see citing works
Self-citation
Practical considerations for conducting ecotoxicity test methods with manufactured nanomaterials: what have we learnt so far?
Handy, R. D., van den Brink, N. W., Chappell, M. A., Mühling, M., Behra, R., Dušinská, M., Simpson, P., Ahtiainen, J., Jha, A. N., Seiter, J. M., et al. (2012) · Ecotoxicology · doi:10.1007/s10646-012-0862-y · Cited by 219 · see citing works
Self-citation
In vitro effects of suspensions of selected nanoparticles (C60 fullerene, TiO2, SiO2) on Mytilus hemocytes
Canesi, L., Ciacci, C., Vallotto, D., Gallo, G., Marcomini, A., & Pojana, G. (2009) · Aquatic Toxicology · doi:10.1016/j.aquatox.2009.10.017 · Cited by 219 · see citing works
Microplastic Detection in Soil Amended With Municipal Solid Waste Composts as Revealed by Transmission Electronic Microscopy and Pyrolysis/GC/MS
Watteau, F., Dignac, M., Bouchard, A., Revallier, A., & Houot, S. (2018) · Frontiers in Sustainable Food Systems · doi:10.3389/fsufs.2018.00081 · Cited by 220 · see citing works
Nanoparticles in the environment: assessment using the causal diagram approach
Smita, S., Gupta, S. K., Bartoňová, A., Dušinská, M., Gutleb, A. C., & Rahman, Q. (2012) · Environmental Health · doi:10.1186/1476-069x-11-s1-s13 · Cited by 208 · see citing works
Silver nanoparticles and silver nitrate cause respiratory stress in Eurasian perch (Perca fluviatilis)
Bilberg, K., Malte, H., Wang, T., & Baatrup, E. (2009) · Aquatic Toxicology · doi:10.1016/j.aquatox.2009.10.019 · Cited by 207 · see citing works
Microplastics and human health: Integrating pharmacokinetics
Prata, J. C. (2023) · Critical Reviews in Environmental Science and Technology · doi:10.1080/10643389.2023.2195798 · Cited by 215 · see citing works
Multifunctional cementitious composites modified with nano titanium dioxide: A review
Li, Z., Ding, S., Yu, X., Han, B., & Ou, J. (2018) · Composites Part A Applied Science and Manufacturing · doi:10.1016/j.compositesa.2018.05.019 · Cited by 187 · see citing works
Function-driven engineering of 1D carbon nanotubes and 0D carbon dots: mechanism, properties and applications
Xu, Q., Li, W., Ding, L., Yang, W., Xiao, H., & Ong, W. (2018) · Nanoscale · doi:10.1039/c8nr08738e · Cited by 185 · see citing works
Analysis, behavior and ecotoxicity of carbon-based nanomaterials in the aquatic environment
Pérez, S., Farré, M., & Barceló, ‪. (2009) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2009.04.001 · Cited by 178 · see citing works
Plastic debris in the ocean: the characterization of marine plastics and their environmental impacts, situation analysis report
Carroll, C., Sousa, J., & Thevenon, F. (2015) · doi:10.2305/iucn.ch.2014.03.en · Cited by 179 · see citing works
Limit-test toxicity screening of selected inorganic nanoparticles to the earthworm Eisenia fetida
Heckmann, L., Hovgaard, M. B., Sutherland, D. S., Autrup, H. N., Besenbacher, F., & Scott-Fordsmand, J. J. (2010) · Ecotoxicology · doi:10.1007/s10646-010-0574-0 · Cited by 174 · see citing works
Source, Distribution and Emerging Threat of Micro-and Nanoplastics to marine Organism and Human Health: Socio-Economic Impact and Management Strategies
Mofijur, M., Ahmed, S. F., Rahman, S. M. A., Arafat Siddiki, S. Y., Islam, A. B. M. S., Shahabuddin, M., Ong, H. C., Mahlia, T. M. I., Djavanroodi, F., & Show, P. L. (2021) · Environmental Research · doi:10.1016/j.envres.2021.110857 · Cited by 172 · see citing works
Toxicogenomic Responses of Nanotoxicity in Daphnia magna Exposed to Silver Nitrate and Coated Silver Nanoparticles
Poynton, H. C., Lazorchak, J. M., Impellitteri, C. A., Blalock, B. J., Rogers, K. R., Allen, H. J., Loguinov, A. V., Heckman, J. L., & Govindasmawy, S. (2012) · Environmental Science & Technology · doi:10.1021/es3001618 · Cited by 169 · see citing works
Bioaccumulation and sub-acute toxicity of zinc oxide nanoparticles in juvenile carp (Cyprinus carpio): A comparative study with its bulk counterparts
Hao, L., Chen, L., Hao, J., & Zhong, N. (2013) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2013.01.007 · Cited by 162 · see citing works
Effects of aqueous suspensions of titanium dioxide nanoparticles on Artemia salina: assessment of nanoparticle aggregation, accumulation, and toxicity
Ateş, M., Daniels, J., Arslan, Z., & Farah, I. O. (2012) · Environmental Monitoring and Assessment · doi:10.1007/s10661-012-2794-7 · Cited by 160 · see citing works
Immunotoxicology of non-functionalized engineered nanoparticles in aquatic organisms with special emphasis on fish—Review of current knowledge, gap identification, and call for further research
Jovanović, B., & Palić, D. (2012) · Aquatic Toxicology · doi:10.1016/j.aquatox.2012.04.005 · Cited by 160 · see citing works
Environmental behaviour and ecotoxicity of quantum dots at various trophic levels: A review
Rocha, T. L., Mestre, N. C., de Sabóia‐Morais, S. M. T., & Bebianno, M. J. (2016) · Environment International · doi:10.1016/j.envint.2016.09.021 · Cited by 160 · see citing works
Toward a molecular understanding of nanoparticle–protein interactions
Treuel, L., & Nienhaus, G. U. (2012) · Biophysical Reviews · doi:10.1007/s12551-012-0072-0 · Cited by 158 · see citing works
An end to the controversy over the microscopic detection and effects of pristine microplastics in fish organs
de Sales‐Ribeiro, C., Brito‐Casillas, Y., Fernández, A., & Caballero, M. J. (2020) · Scientific Reports · doi:10.1038/s41598-020-69062-3 · Cited by 152 · see citing works
Evaluating Nanoparticle Breakthrough during Drinking Water Treatment
Chalew, T. E. A., Ajmani, G. S., Haiou, H., & Schwab, K. J. (2013) · Environmental Health Perspectives · doi:10.1289/ehp.1306574 · Cited by 150 · see citing works
Recent Progress in Nanomaterials for Modern Concrete Infrastructure: Advantages and Challenges
Bautista-Gutierrez, K. P., Herrera‐May, A. L., López, J. M. S., Honorato-Moreno, A., & Castro, S. A. Z. (2019) · Materials · doi:10.3390/ma12213548 · Cited by 150 · see citing works
Techniques and Protocols for Dispersing Nanoparticle Powders in Aqueous Media—Is there a Rationale for Harmonization?
Hartmann, N. B., Jensen, K. A., Baun, A., Rasmussen, K., Rauscher, H., Tantra, R., Cupi, D., Gilliland, D. D., Pianella, F., & Sintes, J. M. R. (2015) · Journal of Toxicology and Environmental Health Part B · doi:10.1080/10937404.2015.1074969 · Cited by 150 · see citing works
Biological accumulation of engineered nanomaterials: a review of current knowledge
Hou, W.-C., Westerhoff, P. K., & Posner, J. D. (2012) · Environmental Science Processes & Impacts · doi:10.1039/c2em30686g · Cited by 147 · see citing works
The occurrence and dietary intake related to the presence of microplastics in drinking water in Saudi Arabia
Almaiman, L., Aljomah, A., Bineid, M., Aljeldah, F. M., Aldawsari, F. S., Liebmann, B., Lomako, I., Sexlinger, K., & Alarfaj, R. (2021) · Environmental Monitoring and Assessment · doi:10.1007/s10661-021-09132-9 · Cited by 148 · see citing works
Ingestion of metal-nanoparticle contaminated food disrupts endogenous microbiota in zebrafish (Danio rerio)
Merrifield, D. L., Shaw, B. J., Harper, G. M., Saoud, I. P., Davies, S. J., Handy, R. D., & Henry, T. B. (2012) · Environmental Pollution · doi:10.1016/j.envpol.2012.11.017 · Cited by 146 · see citing works
Self-citation
Metal oxide nanomaterials in seawater: Linking physicochemical characteristics with biological response in sea urchin development
Fairbairn, E. A., Keller, A. A., Mädler, L., Zhou, D., Pokhrel, S., & Cherr, G. N. (2011) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2011.06.080 · Cited by 143 · see citing works
An introduction to metals in fish physiology and toxicology: basic principles
Wood, C. M. (2011) · Fish physiology · doi:10.1016/s1546-5098(11)31001-1 · Cited by 143 · see citing works
Adsorption and Desorption of Phenanthrene on Carbon Nanotubes in Simulated Gastrointestinal Fluids
Wang, Z., Zhao, J. L., Song, L., Mashayekhi, H., Chefetz, B., & Xing, B. (2011) · Environmental Science & Technology · doi:10.1021/es200790x · Cited by 142 · see citing works
Aquatic Ecotoxicity Testing of Nanoparticles—The Quest To Disclose Nanoparticle Effects
Skjolding, L. M., Sørensen, S. N., Hartmann, N. B., Hjorth, R., Hansen, S. F., & Baun, A. (2016) · Angewandte Chemie International Edition · doi:10.1002/anie.201604964 · Cited by 141 · see citing works
Silver nanoparticles cause oxidative damage and histological changes in medaka (Oryzias latipes) after 14 days of exposure
Wu, Y., & Zhou, Q. (2012) · Environmental Toxicology and Chemistry · doi:10.1002/etc.2038 · Cited by 139 · see citing works
Galantamine-loaded solid–lipid nanoparticles for enhanced brain delivery: preparation, characterization, <i>in vitro</i> and <i>in vivo</i> evaluations
Misra, S., Chopra, K., Sinha, V. R., & Medhi, B. (2016) · Drug Delivery · doi:10.3109/10717544.2015.1089956 · Cited by 136 · see citing works
Surface Properties Dictate Uptake, Distribution, Excretion, and Toxicity of Nanoparticles in Fish
Zhu, Z., Carboni, R., Quercio, M. J., Yan, B., Miranda, O. R., Anderton, D. L., Arcaro, K. F., Rotello, V. M., & Vachet, R. W. (2010) · Small · doi:10.1002/smll.201000989 · Cited by 129 · see citing works
The biophysicochemical interactions at the interfaces between nanoparticles and aquatic organisms: adsorption and internalization
Ma, S., & Lin, D. (2012) · Environmental Science Processes & Impacts · doi:10.1039/c2em30637a · Cited by 128 · see citing works
Comparative metal oxide nanoparticle toxicity using embryonic zebrafish
Wehmas, L. C., Anders, C. B., Chess, J., Punnoose, A., Pereira, C. B., Greenwood, J. A., & Tanguay, R. L. (2015) · Toxicology Reports · doi:10.1016/j.toxrep.2015.03.015 · Cited by 125 · see citing works
Microplastics as an aquatic pollutant affect gut microbiota within aquatic animals
Li, W., Chen, X., Li, M., Cai, Z., Gong, H., & Yan, M. (2021) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2021.127094 · Cited by 123 · see citing works
Zinc oxide nanoparticles alter hatching and larval locomotor activity in zebrafish (Danio rerio)
Chen, T.-H., Lin, C.-C., & Meng, P. (2013) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2013.12.030 · Cited by 122 · see citing works
Trophic transfer of metal-based nanoparticles in aquatic environments: a review and recommendations for future research focus
Tangaa, S. R., Selck, H., Winther-Nielsen, M., & Khan, F. R. (2016) · Environmental Science Nano · doi:10.1039/c5en00280j · Cited by 118 · see citing works
Toxicological effects of graphene oxide on adult zebrafish (Danio rerio)
Souza, J. P., Baretta, J. F., dos Santos, F. A., Paino, I. M. M., & Zucolotto, V. (2017) · Aquatic Toxicology · doi:10.1016/j.aquatox.2017.02.017 · Cited by 118 · see citing works
Behavioral effects of titanium dioxide nanoparticles on larval zebrafish (Danio rerio)
Chen, T.-H., Lin, C.-Y., & Tseng, M. (2011) · Marine Pollution Bulletin · doi:10.1016/j.marpolbul.2011.04.017 · Cited by 116 · see citing works
The influence of natural organic matter and aging on suspension stability in guideline toxicity testing of silver, zinc oxide, and titanium dioxide nanoparticles with Daphnia magna
Cupi, D., Hartmann, N. B., & Baun, A. (2014) · Environmental Toxicology and Chemistry · doi:10.1002/etc.2855 · Cited by 114 · see citing works
Nanoparticles: An Experimental Study of Zinc Nanoparticles Toxicity on Marine Crustaceans. General Overview on the Health Implications in Humans
Vimercati, L., Cavone, D., Caputi, A., Maria, L. D., Tria, M., Prato, E., & Ferri, G. M. (2020) · Frontiers in Public Health · doi:10.3389/fpubh.2020.00192 · Cited by 113 · see citing works
Comparative toxicity of CuO nanoparticles and CuSO4 in rainbow trout
Isani, G., Falcioni, M. L., Barucca, G., Sekar, D., Andreani, G., Carpenè, E., & Falcioni, G. (2013) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2013.07.001 · Cited by 111 · see citing works
Fate of TiO2 nanoparticles entering sewage treatment plants and bioaccumulation in fish in the receiving streams
Shi, X., Li, Z., Chen, W., Qiang, L., Xia, J., Chen, M., Zhu, L. Y., & Alvarez, P. J. J. (2016) · NanoImpact · doi:10.1016/j.impact.2016.09.002 · Cited by 111 · see citing works
Effects of manufactured nanomaterials on fishes: a target organ and body systems physiology approach
Handy, R. D., Al-Bairuty, G. A., Al-Jubory, A. R., Ramsden, C. S., Boyle, D., Shaw, B. J., & Henry, T. B. (2011) · Journal of Fish Biology · doi:10.1111/j.1095-8649.2011.03080.x · Cited by 108 · see citing works
Self-citation
Harmful Effects of Nanoparticles on Animals
Exbrayat, J., Moudilou, E., & Lapied, E. (2015) · Journal of Nanotechnology · doi:10.1155/2015/861092 · Cited by 108 · see citing works
Sunscreens: UV filters to protect us: Part 2-Increasing awareness of UV filters and their potential toxicities to us and our environment
Fivenson, D., Sabzevari, N., Qiblawi, S., Blitz, J., Norton, B. B., & Norton, S. A. (2021) · International Journal of Women's Dermatology · doi:10.1016/j.ijwd.2020.08.008 · Cited by 107 · see citing works
Oxidative Stress and Nano-Toxicity Induced by TiO2 and ZnO on WAG Cell Line
Dubey, A., Goswami, M., Yadav, K., & Chaudhary, D. K. (2015) · PLoS ONE · doi:10.1371/journal.pone.0127493 · Cited by 107 · see citing works
Efficacy of the hatching event in assessing the embryo toxicity of the nano-sized TiO2 particles in zebrafish: A comparison between two different classes of hatching-derived variables
Samaee, S., Rabbani, S., Jovanović, B., Mohajeri‐Tehrani, M. R., & Haghpanah, V. (2015) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2015.03.012 · Cited by 105 · see citing works
Microplastics Pollution as an Invisible Potential Threat to Food Safety and Security, Policy Challenges and the Way Forward
Usman, S., Razis, A. F. A., Shaari, K., Amal, M. N. A., Saad, M. Z., Isa, N. M., Nazarudin, M. F., Zulkifli, S. Z., Sutra, J., & Ibrahim, M. A. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17249591 · Cited by 106 · see citing works
Uptake and depuration kinetics of microplastics with different polymer types and particle sizes in Japanese medaka (Oryzias latipes)
Liu, Y., Qiu, X., Xu, X., Takai, Y., Ogawa, H., Shimasaki, Y., & Oshima, Y. (2021) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2021.112007 · Cited by 105 · see citing works
Toxicity of Therapeutic Nanoparticles
Maurer‐Jones, M. A., Bantz, K. C., Love, S. A., Marquis, B. J., & Haynes, C. L. (2009) · Nanomedicine · doi:10.2217/17435889.4.2.219 · Cited by 105 · see citing works
Genotoxicity and oxidative stress in fish after a short-term exposure to silver nanoparticles
Bacchetta, C., Ale, A., Simoniello, M. F., Gervasio, S., Davico, C. E., Rossi, A., Desimone, M. F., Poletta, G. L., López, G., Monserrat, J. M., et al. (2017) · Ecological Indicators · doi:10.1016/j.ecolind.2017.01.018 · Cited by 104 · see citing works
Environmental impacts due to the use of sunscreen products: a mini-review
Chatzigianni, M., Pavlou, P., Siamidi, A., Vlachou, M., Varvaresou, A., & Papageorgiou, S. (2022) · Ecotoxicology · doi:10.1007/s10646-022-02592-w · Cited by 104 · see citing works
High Doses of Intravenously Administered Titanium Dioxide Nanoparticles Accumulate in the Kidneys of Rainbow Trout but with no Observable Impairment of Renal Function
Scown, T. M., van Aerle, R., Johnston, B. D., Cumberland, S. A., Lead, J. R., Owen, R., & Tyler, C. R. (2009) · Toxicological Sciences · doi:10.1093/toxsci/kfp064 · Cited by 104 · see citing works
Self-citation
Effect of cultivation media on the toxicity of ZnO nanoparticles to freshwater and marine microalgae
Aravantinou, A. F., Tsarpali, V., Dailianis, S., & Manariotis, I. D. (2015) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2015.01.016 · Cited by 103 · see citing works
The known unknowns of nanomaterials: Describing and characterizing uncertainty within environmental, health and safety risks
Grieger, K., Hansen, S. F., & Baun, A. (2009) · Nanotoxicology · doi:10.1080/17435390902944069 · Cited by 103 · see citing works
Nanotoxicity: Dimensional and Morphological Concerns
Wani, M. Y., Hashim, M. A., Nabi, F., & Malik, M. A. (2011) · Advances in Physical Chemistry · doi:10.1155/2011/450912 · Cited by 102 · see citing works
Genotoxicity, potential cytotoxicity and cell uptake of titanium dioxide nanoparticles in the marine fish Trachinotus carolinus (Linnaeus, 1766)
Vignardi, C. P., Hasue, F. M., Sartório, P. V., Cardoso, C. M., Machado, A. S. D., Passos, M. J. D. A. C. R., Santos, T. C. A., Garcia, J. M. R. N., Hewer, T. L. R., Watanabe, I., et al. (2014) · Aquatic Toxicology · doi:10.1016/j.aquatox.2014.11.008 · Cited by 101 · see citing works
The behavior and effects of nanoparticles in the environment
Nowack, B. (2009) · Environmental Pollution · doi:10.1016/j.envpol.2008.12.019 · Cited by 101 · see citing works
Preliminary evaluation of risks related to waste incineration of polymer nanocomposites
Roes, A. L., Patel, M. K., Worrell, E., & Ludwig, C. D. R. (2012) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2011.12.030 · Cited by 100 · see citing works
Dietary toxicity of single-walled carbon nanotubes and fullerenes (C60) in rainbow trout (Oncorhynchus mykiss)
Fraser, T. W. K., Reinardy, H. C., Shaw, B. J., Henry, T. B., & Handy, R. D. (2010) · Nanotoxicology · doi:10.3109/17435390.2010.502978 · Cited by 99 · see citing works
Self-citation
Effect of long‐term exposure of silver nanoparticles on growth indices, hematological and biochemical parameters and gonad histology of male goldfish (Carassius auratus gibelio)
Vajargah, M. F., Imanpoor, M. R., Shabani, A., Hedayati, A., & Faggio, C. (2019) · Microscopy Research and Technique · doi:10.1002/jemt.23271 · Cited by 98 · see citing works
The effects of silver nanoparticles (Ag-NPs) sublethal concentrations on common carp (Cyprinus carpio): Bioaccumulation, hematology, serum biochemistry and immunology, antioxidant enzymes, and skin mucosal responses
Vali, S., Mohammadi, G., Tavabe, K. R., Moghadas, F., & Naserabad, S. S. (2020) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2020.110353 · Cited by 96 · see citing works

Effects of manufactured nanomaterials on fishes: a target organ and body systems physiology approach
Handy, R. D., Al-Bairuty, G. A., Al-Jubory, A. R., Ramsden, C. S., Boyle, D., Shaw, B. J., & Henry, T. B. (2011) · Journal of Fish Biology · doi:10.1111/j.1095-8649.2011.03080.x · Cited by 108 · see citing works
Self-citation
TiO2 nanoparticles intake by fish gill cells following exposure
Diniz, M., Matos, A., Lourenço, J., Castro, L., Peres, I., Mendonça, E., & Picado, A. (2013) · Microscopy and Microanalysis · doi:10.1017/s1431927613000974 · Cited by 1 · see citing works
Addressing the effects of short-term exposure to TiO2 nanoparticles in fish gills: An ex-vivo approach
da Silva, M. E. (2017) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)
THE ECOTOXICOLOGY OF ENGINEERED NANOPARTICLES TO FRESHWATER FISH
Shaw, B. J. (2011) · OpenGrey (Institut de l'Information Scientifique et Technique) · doi:10.24382/4809
Uptake and effects of nanoparticles in fish
Scown, T. M. (2009) · Open Research Exeter (University of Exeter) · Cited by 7 · see citing works
Self-citation

Authors: Handy, R. D., Henry, T. B., Scown, T. M., Johnston, B. D., & Tyler, C. R.
Affiliations: University of Plymouth (GB)
University of Exeter (GB)
Corresponding author: Handy, Richard D.
ORCID: Handy, Richard D.
Henry, Theodore B.
Johnston, Blair D.
Tyler, Charles R.
Venue: Ecotoxicology
Publisher: Springer Science and Business Media LLC
Published: 2008-04-12
Volume: 17
Issue: 5
Pages: 396-409
ISSN: 0963-9292 (ISSN-L)
1573-3017
DOI: 10.1007/s10646-008-0205-1
OpenAlex: W2056008081
Cited by: 447
References: 71
Citations by year: 2026: 9 · 2025: 14 · 2024: 18 · 2023: 26 · 2022: 20 · 2021: 42 · 2020: 27 · 2019: 25 · 2018: 28 · 2017: 27 · 2016: 28 · 2015: 26 · 2014: 30 · 2013: 23 · 2012: 31
FWCI: 16.77
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Ecotoxicology (publishedVersion)
PubMed (publishedVersion)
Funders: U.S. Environmental Protection Agency
Natural Environment Research Council (NE/E014496/1, NE/E014348/1)
Topics: Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Environmental Toxicology and Ecotoxicology
Physical Sciences › Materials Science › Materials Chemistry › Nanoparticles: synthesis and applications
Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
Keywords: engineered nanomaterials, nanoparticles, fish toxicology, nanoparticle uptake, ADME, titanium dioxide, C60, endocytosis, bioavailability, hepatic excretion, chemical reactivity, mechanistic toxicology, fish cell culture
MeSH terms: Animals, Fishes, Titanium, Ecosystem, Fullerenes, Nanotubes, Carbon, Nanoparticles

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Manufactured nanoparticles: their uptake and effects on fish—a mechanistic analysis

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks