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Evaluation of Collagen Crosslinking Techniques
Abstract
The properties of collagen films crosslinked by physical and chemical techniques were compared to the properties of films crosslinked with glutaraldehyde (GTA). Physical techniques studied include exposure to short wave (254 nm) u.v. irradiation and severe dehydration. Chemical techniques studied include immersion of collagen films in aqueous solutions of cyanamide or GTA. Collagen films exposed to combinations of aqueous solutions of cyanamide and severe dehydration had moduli of elasticity, swelling ratios and resistance to bacterial collagenase similar to films crosslinked with GTA. Theoretical calculations based on amino acid composition indicate that approximately seven times as many amino acid residues are capable of forming crosslinks using cyanamide or severe dehydration procedures as compared to GTA crosslinking. In addition, using severe dehydration or cyanamide forms crosslinks involving both amino and carboxyl residues which may allow these procedures to act synergistically. Based on our studies this two-step procedure effectively crosslinks collagen-based biomaterials while the only by-product of this reaction is water-soluble urea. Preliminary biocompatibility studies suggest that this crosslinking procedure may allow for pronounced tissue ingrowth.
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Citations
Cited by
Acellular vascular tissues: natural biomaterials for tissue repair and tissue engineering
Schmidt, C. E., & Baier, J. M. (2000) · Biomaterials · doi:10.1016/s0142-9612(00)00148-4 · Cited by 762
Oryan, A., Kamali, A., Moshiri, A., Baharvand, H., & Daemi, H. (2018) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2017.08.184 · Cited by 500
Chevallay, B., & Herbage, D. (2000) · Medical & Biological Engineering & Computing · doi:10.1007/bf02344779 · Cited by 403
Bi, L., Cao, Z., Hu, Y., Song, Y., Yu, L., Yang, B., Mu, J., Huang, Z., & Han, Y. (2011) · Journal of Materials Science: Materials in Medicine · doi:10.1007/s10856-010-4177-3 · Cited by 215
Development of fibroblast‐seeded ligament analogs for ACL reconstruction
Dunn, M. G., Liesch, J. B., Tiku, M. L., & Zawadsky, J. P. (1995) · Journal of Biomedical Materials Research · doi:10.1002/jbm.820291107 · Cited by 206
Metadata
- Authors
- Weadock, K., Olson, R. M., & Silver, F. H.
- Venue
- Biomaterials, Medical Devices, and Artificial Organs
- Publisher
- Informa UK Limited
- Published
- 1983-01
- Volume
- 11
- Issue
- 4
- Pages
- 293-318
- ISSN
- 0090-5488 (ISSN-L)
- OpenAlex
- W2153182002
- Cited by
- 344
- References
- 0
- FWCI
- 1.46
- Type
- journal article
- Language
- en
- Open access
- closed
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- Weadock, K., Olson, R. M., & Silver, F. H. (1983). Evaluation of Collagen Crosslinking Techniques. Biomaterials, Medical Devices, and Artificial Organs. https://doi.org/10.3109/10731198309118815
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