Gut Fermentation (or the ‘Auto-brewery’) Syndrome: A New Clinical Test with Initial Observations and Discussion of Clinical and Biochemical Implications
Abstract
In order to identify those patients who ferment dietary carbohydrate to ethanol in their gut, a new clinical test which is easy to perform is described whereby blood alcohol (EtOH) levels are measured 1 h after a 5 g glucose load in patients who have abstained from EtOH for 24 h and who have fasted for at least 3 h prior to the test. In patients, 25/36 (69%) undergoing a 50 g oral glucose tolerance test and 311/510 (61%) undergoing the 5 g loading produced measurable blood EtOH levels after 1 h. Some clinical and biochemical implications are discussed. It is proposed that this new test could be of considerable help in clinical evaluation of a significant number of unwell patients.
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There is some evidence to suggest that yeast overgrowth in the gut, usually Candida or Saccharomyces species, can cause an accumulation of ethanol.
“There is some evidence to suggest that yeast overgrowth in the gut, usually Candida or Saccharomyces species, can cause an accumulation of ethanol [79, 80].”
From Pilot study of probiotic/colostrum supplementation on gut function in children with autism and gastrointestinal symptoms (2019) · cites this paper as [79]
Cites
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- Authors
- Hunnisett, A., Howard, J., & Davies, S.
- Venue
- Journal of Nutritional Medicine
- Publisher
- Informa UK Limited
- Published
- 1990-01
- Volume
- 1
- Issue
- 1
- Pages
- 33-38
- ISSN
- 0955-6664 (ISSN-L)
- OpenAlex
- W2027467596
- Cited by
- 49
- References
- 13
- Citations by year
- 2025: 2 · 2024: 3 · 2020: 3 · 2019: 3 · 2018: 1 · 2017: 1 · 2015: 1 · 2013: 2 · 2012: 1
- FWCI
- 0.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Nutritional Medicine (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Keywords
- auto-brewery syndrome, gut fermentation, blood ethanol levels, glucose tolerance test, oral glucose load, carbohydrate fermentation, ethanol production, clinical diagnostic tests
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