Timetable of effects of testosterone administration to hypogonadal men on variables of sex and mood
Open accessAbstract
INTRODUCTION: The effects of testosterone have been extensively characterized, but little attention has been given to the timetable of occurrence of the various effects of testosterone. METHODS: The timetables of effects on sexual and psychological variables in 40 hypogonadal men receiving treatment with either parenteral testosterone enanthate (TE) or undecanoate (TU). RESULTS: Sexual thoughts/fantasies and sexual interest/desire/spontaneous morning erections emerged quickly and plateaued after 3 weeks. Total erections rose to a maximum over 9 weeks and then plateaued. Ejaculations per week/satisfaction with sex life rose over the first 3 weeks, increasing steadily to a plateau at 12 weeks. Depression scores decreased to reach a plateau after 6 weeks. Aggressiveness did not change. Scores of concentration improved and reached a plateau after 3 weeks in the group treated with TE and after 9 weeks in the group treated with TU. Good mood improved after 6-9 weeks. Positive effects on self-confidence appeared between 3-6 weeks and on fatigue after 9-12 weeks. CONCLUSION: Insight into the emergence of effects may be useful information for the patient and for the attending physician in monitoring clinical effects of testosterone treatment of hypogonadal men.
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Effects of testosterone on sexual interest appear after 3 weeks and plateau at 6 weeks, with no further increments expected beyond that.
“Effects on sexual interest appear after 3 weeks plateauing at 6 weeks, with no further increments expected beyond.”
From Onset of effects of testosterone treatment and time span until maximum effects are achieved (2011) · cites this paper as [68]
Effects of testosterone on libido, sexual desire, sexual thoughts and fantasies, and satisfaction with sexual life manifest after 3 weeks or 30 days.
“Effects on libido, sexual desire, sexual thoughts and fantasies and satisfaction with sexual life manifest themselves rather rapidly: after 3 weeks (68) or 30 days (14).”
From Onset of effects of testosterone treatment and time span until maximum effects are achieved (2011) · cites this paper as [68]
Ejaculations increase after 2 weeks and sexual activity after 3 weeks of testosterone treatment.
“an increase of ejaculations and sexual activity after 2 weeks (70) and 3 weeks respectively (68).”
From Onset of effects of testosterone treatment and time span until maximum effects are achieved (2011) · cites this paper as [68]
Effects of testosterone on erection appear after 3 weeks.
“Effects on erection also appear rather rapidly: after 3 weeks (68).”
From Onset of effects of testosterone treatment and time span until maximum effects are achieved (2011) · cites this paper as [68]
Morning erections increase after 3 weeks of testosterone treatment.
“Increase in morning erections occur after 3 weeks (68).”
From Onset of effects of testosterone treatment and time span until maximum effects are achieved (2011) · cites this paper as [68]
Decrease in fatigue and listlessness occurs after 1 month or 6 weeks of testosterone treatment.
“A decrease in fatigue and listlessness was found after 1 month (31) or 6 weeks (68).”
From Onset of effects of testosterone treatment and time span until maximum effects are achieved (2011) · cites this paper as [68]
Increase in sociability, decrease in anxiety, increase in concentration, and increase in self-confidence are apparent after 3 weeks of testosterone treatment.
“A number of psychological variables (increase in sociability, decrease in anxiety, increase in concentration, and self-confidence) were apparent after 3 weeks (68).”
From Onset of effects of testosterone treatment and time span until maximum effects are achieved (2011) · cites this paper as [68]
Improvement in depression is reported after 3 weeks or 1 month of testosterone treatment.
“Several studies report an improvement in depression after 3 weeks (68) or 1 month (38).”
From Onset of effects of testosterone treatment and time span until maximum effects are achieved (2011) · cites this paper as [68]
Increase in good mood and decrease in bad mood occur after 3 weeks or 30 days of testosterone treatment.
“Increase in good mood and a decrease in bad mood were noted after 3 weeks (68) or after 30 days (14).”
From Onset of effects of testosterone treatment and time span until maximum effects are achieved (2011) · cites this paper as [68]
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- Authors
- Jockenhövel, F., Minnemann, T., Schubert, M., Freude, S., Hübler, D., Schumann, C., Christoph, A., Gooren, L., & Ernst, M.
- Affiliations
- University of Cologne (DE)
- Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
- Venue
- The Aging Male
- Publisher
- Informa UK Limited
- Published
- 2009-10-06
- Volume
- 12
- Issue
- 4
- Pages
- 113-118
- ISSN
- 1368-5538 (ISSN-L)
- 1473-0790
- OpenAlex
- W2035015826
- Cited by
- 31
- References
- 19
- Citations by year
- 2022: 1 · 2020: 3 · 2019: 1 · 2018: 1 · 2017: 3 · 2016: 2 · 2015: 1 · 2014: 4 · 2013: 4 · 2012: 3
- FWCI
- 2.43
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Aging Male (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- OPUS (Augsburg University) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- testosterone replacement therapy, hypogonadism, testosterone enanthate, testosterone undecanoate, sexual function, sexual desire, erection, ejaculation, sexual satisfaction, depression, aggression, concentration, mood, self-confidence, fatigue
- MeSH terms
- Affect, Androgens, Humans, Hypogonadism, Male, Prospective Studies, Surveys and Questionnaires, Testosterone, Time Factors, Sexuality
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