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Cited by 16Menopause: Health Impacts and TreatmentsNutrition and Health StudiesFolate and B Vitamins Research

Menopause and age-driven changes in blood level of fat- and water-soluble vitamins

Wiacek, M., Zubrzycki, I. Z., Bojke, O., Kim, H-J.·2013·Climacteric
DOI 10.3109/13697137.2012.742504
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Abstract

OBJECTIVE: The purpose of this cross-sectional study was to assess the association of the menopausal transition with changes in vitamins. METHODS: The study group comprised women aged 17-85 years from the Third National Health and Nutrition Examination Survey (NHANES), which was conducted between 1988 and 1994, and from the NHANES surveys conducted between 1999 and 2006. Menopausal status was defined using the time since the last period, < 2, 2-12, and > 12 months, for the pre-, peri-, and postmenopause, respectively. The data-cleaning technique employing serum follicle stimulating hormone activity resulted in pre-, peri- and postmenopausal samples encompassing the following age brackets: 17-50, 42-51, and 46-85 years. Statistical inferences were analyzed using non-parametric techniques. RESULTS: Significant increases in vitamin A and vitamin E concentrations across all phases of the menopausal transition were observed. There was a gradual decrease in the vitamin C concentration across all stages of the menopause but a fairly stable concentration of vitamin B12. There was a statistically significant increase in vitamin D between the pre- and postmenopause. Body mass index correlated negatively with serum vitamin concentration in the pre- and postmenopause. CONCLUSIONS: Vitamin A should be supplemented in postmenopausal women to decrease the risk of bone fracture. The daily diet should be supplemented with vitamin B12, to avoid possible neurological symptoms due to vitamin B12 deficiency, and with vitamin D to decrease the risk of developing secondary hyperparathyroidism. Due to an adverse influence on serum vitamin concentration, body mass index should be monitored in pre- and postmenopausal women.

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  • Menopause affects utilization of micronutrients; for example, vitamin C gradually decreases as menopause advances, correlated negatively to body mass index.

    “Furthermore, menopause affects utilization of micronutrients; for example, vitamin C gradually decreases as menopause advances, correlated negatively to body mass index [102].”

    From Immune function and micronutrient requirements change over the life course (2018) · cites this paper as [102]

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Authors
Wiacek, M., Zubrzycki, I. Z., Bojke, O., & Kim, H.-J.
Affiliations
  • Gdansk University of Physical Education and Sport (PL)
  • Hanyang University (KR)
ORCID
Zubrzycki, I. Z.
Venue
Climacteric
Publisher
Informa UK Limited
Published
2012-12-10
Volume
16
Issue
6
Pages
689-699
ISSN
  • 1369-7137 (ISSN-L)
  • 1473-0804
DOI
10.3109/13697137.2012.742504
OpenAlex
W2063021728
Cited by
16
References
70
Citations by year
2026: 3 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 1 · 2018: 1 · 2017: 1 · 2016: 1 · 2014: 3
FWCI
0.77
Type
journal article
Language
en
Open access
closed
Locations
  • Climacteric (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutrition and Health Studies
  • Health Sciences › Medicine › Rheumatology › Folate and B Vitamins Research
Keywords
menopause, postmenopausal women, serum vitamin levels, vitamin A, vitamin E, vitamin C, vitamin B12, vitamin D, body mass index, follicle-stimulating hormone, age-related changes, bone fracture risk, secondary hyperparathyroidism
MeSH terms
Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Aging, Ascorbic Acid, Cross-Sectional Studies, Health Surveys, Humans, Menopause, Middle Aged, Vitamin A, Vitamin B 12, Vitamin D, Vitamin E, Vitamins, Premenopause, Postmenopause, Perimenopause, Young Adult

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