The anti-wrinkle efficacy of Argireline
Abstract
BACKGROUND: Argireline, a synthetic peptide, which is patterned from the N-terminal end of the protein SNAP-25, can both reduce the degree of existing facial wrinkles and demonstrate effectively against their development. In our past studies, we found out that Argireline had a significant anti-wrinkle effect in Chinese subjects and that it was safe and well tolerated. OBJECTIVE: To observe the effect of Argireline on histological changes in the skin in the aged mice induced by D-galactose. METHODS: Argireline was applied to the aged mice twice daily for 6 weeks. The histological changes in skin tissue were evaluated using hematoxylin-eosin (HE) and picrosirius-polarization (PSP) stains. The amount of type I and of type III collagen fibers were also semi-quantitatively compared using software Image-ProPlus. RESULTS: There was an improvement in the histological structure of skin tissue in the aged mice; the amount of type I collagen fibers increased (P < 0.01), while that of type III collagen fibers decreased (P < 0.05). CONCLUSIONS: This study revealed that Argireline could improve the histological structure of skin tissue and rejuvenate the aging skin.
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Wang et al. reported that Argireline showed promising results in reducing appearance of wrinkles, with improvements in skin texture and overall wrinkle reduction.
“The researchers reported that Argireline showed promising results in reducing the appearance of wrinkles, with participants experiencing improvements in skin texture and overall wrinkle reduction.”
From Cosmeceuticals in photoaging: A review. (2024) · cites this paper as [56]
Wang et al.'s study did not provide clear details on methodology used.
“However, the study only included a small sample size and did not provide clear details on the methodology used.”
From Cosmeceuticals in photoaging: A review. (2024) · cites this paper as [56]
Wang et al.'s study on Argireline has relatively low level of evidence because it is small-scale and lacks a control group.
“However, the level of evidence according to the Oxford Centre for Evidence‐Based Medicine is relatively low, as it is a small‐scale study and lacks a control group for comparison.”
From Cosmeceuticals in photoaging: A review. (2024) · cites this paper as [56]
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Cosmeceuticals in photoaging: A review.
Chan, L. K. W., Lee, K. W. A., Lee, C. H., Lam, K. W. P., Lee, K. F. V., Wu, R., Wan, J., Shivananjappa, S., Sky, W. T. H., Choi, H., et al. (2024) · Skin Research and Technology · doi:10.1111/srt.13730 · Cited by 23 · see citing works
- Authors
- Wang, Y., Wang, M., Xiao, X. S., Huo, J., & Zhang, W. D.
- Affiliations
- Second Affiliated Hospital of Xi'an Jiaotong University (CN)
- Corresponding author
- Wang, Yuan
- Wang, Mei
- Venue
- Journal of Cosmetic and Laser Therapy
- Publisher
- Informa UK Limited
- Published
- 2013-03-06
- Volume
- 15
- Issue
- 4
- Pages
- 237-241
- ISSN
- 1476-4172 (ISSN-L)
- 1476-4180
- OpenAlex
- W2130325212
- Cited by
- 34
- References
- 17
- Citations by year
- 2026: 5 · 2025: 9 · 2024: 4 · 2023: 5 · 2022: 3 · 2021: 2 · 2020: 2 · 2019: 1 · 2017: 3
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Cosmetic and Laser Therapy (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Health Sciences › Medicine › Dermatology › Facial Rejuvenation and Surgery Techniques
- Health Sciences › Medicine › Dermatology › Dermatologic Treatments and Research
- Keywords
- skin aging, D-galactose-induced aging, type I collagen, type III collagen, skin histology, synthetic peptides, SNAP-25, skin rejuvenation
- MeSH terms
- Animals, Oligopeptides, Skin, Staining and Labeling, Skin Aging, Collagen Type I, Collagen Type III, Mice
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