Alleviation of Ultraviolet B-Induced Photoaging by 7-MEGATM 500 in Hairless Mouse Skin
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The purpose of this study was to investigate the effect of 7-MEGA™ 500 on the improvement of skin aging in an UVB-induced photo-aging model of hairless mice. The dorsal skin of hairless mice was exposed to UVB three times a week for 12 weeks to induce skin wrinkle. After inducing the wrinkle, 7-MEGA™ 500 was orally administered once a day for 4 weeks. Skin thickness, skin barrier function, and wrinkle indicators were improved by treatment with 7-MEGA™ 500. Both gene and protein expression levels of MMP-3 and c-Jun in skin were significantly decreased by 7-MEGA™ 500. Therefore, the intake of 7-MEGA™ 500 is thought to have a positive effect on the improvement of skin aging, although further studies are needed.
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Oral supplementation with 7-MEGA 500, an unsaturated fatty acid, could alleviate UVB-induced photoaging in hairless mouse skin.
“Oral supplementation with 7-MEGATM 500, an unsaturated fatty acid, could alleviate UVB-induced photoaging in hairless mouse skin.”
From Boosting the Photoaged Skin: The Potential Role of Dietary Components (2021) · cites this paper as [128]
Oral treatment with 7-MEGA 500 improved skin thickness, skin barrier function, and wrinkle indicators, and reduced expression of MMP-3 and c-Jun, in mouse dorsal skin.
“Oral treatment with 7-MEGA™ 500 improved skin thickness, skin barrier function, and wrinkle indicators, and reduced the expression of MMP-3 and c-Jun, in mouse dorsal skin [128].”
From Boosting the Photoaged Skin: The Potential Role of Dietary Components (2021) · cites this paper as [128]
Oral 7-MEGATM 500 (a product containing more than 50% palmitoleic acid containing fish oil, omega-7) relieves UV-B and H2O2-induced skin oxidative stress, inflammation, aging, and promotes skin regeneration in mice.
“Oral 7-MEGATM 500 (a product containing more than 50% palmitoleic acid containing fish oil, omega-7) has been shown to relieve UV-B and H2O2-induced skin oxidative stress, inflammation, aging, and promotes skin regeneration in mice [126,127].”
From Diet and Skin Aging—From the Perspective of Food Nutrition (2020) · cites this paper as [126]
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References 22 · Cited by 16
- Authors
- Park, K.-H., Kim, J., Jung, S., Sung, K.-H., Son, Y.-K., Bae, J. M., & Kim, B.-H.
- Affiliations
- Keimyung University (KR)
- Environmental Health Services Center, Daegu Catholic University, Daegu, Korea
- R&D Team, Food & Supplement Health Claims, Vitech, Jeonju, Korea
- Korea National Food Cluster (KR)
- Corresponding author
- Kim, Bae-Hwan
- Venue
- Toxicological Research
- Published
- 2019-10-15
- Volume
- 35
- Issue
- 4
- Pages
- 353-359
- ISSN
- 1976-8257 (ISSN-L)
- 2234-2753
- PMC
- PMC6791660
- OpenAlex
- W2980130056
- Cited by
- 16
- References
- 22
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 2 · 2023: 3 · 2021: 3 · 2020: 2 · 2019: 1
- FWCI
- 1.51
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Toxicological Research (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Keywords
- photoaging, UV-B radiation, skin aging, hairless mice, wrinkles, skin barrier function, skin thickness, MMP-3, c-Jun, oral administration, dietary supplements
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