Cited by 155Maternal Mental Health During Pregnancy and PostpartumMaternal and Neonatal HealthcarePregnancy and Medication Impact

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Depression during pregnancy: a risk factor for adverse neonatal outcomes? A critical review of the literature

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Szegda, Kathleen, Markenson, Glenn, Bertone-Johnson, Elizabeth R., Chasan-Taber, Lisa·2014·The Journal of Maternal-Fetal & Neonatal Medicine

DOI 10.3109/14767058.2013.845157PMC PMC4812822

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Abstract

OBJECTIVE: We reviewed studies of maternal depression and preterm birth (PTB), low birthweight (LBW) and small-for-gestational-age (SGA) in the context of methodological differences between studies and potential limitations. METHODS: We conducted a literature search of PubMed (1996-2011) for English-language studies of maternal depression and (1) PTB and gestational age (GA), (2) LBW and birthweight (BW) and (3) SGA. Thirty-six studies met eligibility criteria. RESULTS: Elevated depression levels, particularly in early- to mid-pregnancy, appear to increase risk of PTB and SGA. Findings suggest an increased risk for LBW, but were less consistent. Methodological differences and limitations likely contributed to conflicting findings. A wide range of depression measures were used with the majority of studies utilizing measures not designed, or validated, for pregnant women. Studies failed to assess depression at multiple pregnancy time points, thus constraining the ability to assess the impact of duration and pattern of exposure to depression. Antidepressant use and co-morbid psychosocial factors were rarely considered as potential confounders or effect modifiers. CONCLUSIONS: Studies suggest that depression during pregnancy may be an important risk factor for PTB and SGA, and possibly LBW. Improved study methodology is needed to elucidate the consequence of maternal depression on adverse birth outcomes.

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Authors: Szegda, K., Markenson, G., Bertone-Johnson, E. R., & Chasan-Taber, L.
Affiliations: University of Massachusetts Amherst (US)
Baystate Medical Center (US)
ORCID: Markenson, Glenn
Venue: The Journal of Maternal-Fetal & Neonatal Medicine
Publisher: Informa UK Limited
Published: 2013-10-17
Volume: 27
Issue: 9
Pages: 960-967
ISSN: 1476-4954 (ISSN-L)
1476-7058
DOI: 10.3109/14767058.2013.845157
PMC: PMC4812822
OpenAlex: W2022742917
Cited by: 155
References: 58
Citations by year: 2026: 5 · 2025: 5 · 2024: 8 · 2023: 19 · 2022: 21 · 2021: 16 · 2020: 23 · 2019: 14 · 2018: 12 · 2017: 8 · 2016: 6 · 2015: 12 · 2014: 6
FWCI: 1.14
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: The Journal of Maternal-Fetal & Neonatal Medicine (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (R01DK064902)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Maternal and Neonatal Healthcare
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pregnancy and Medication Impact
Keywords: maternal depression, pregnancy, preterm birth, low birth weight, small for gestational age, adverse neonatal outcomes, antidepressant use, psychosocial comorbidity, gestational age
MeSH terms: Depression, Depressive Disorder, Female, Humans, Infant, Low Birth Weight, Infant, Newborn, Infant, Newborn, Diseases, Infant, Small for Gestational Age, Pregnancy, Pregnancy Complications, Pregnancy Outcome, Risk Factors, Premature Birth

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Depression during pregnancy: a risk factor for adverse neonatal outcomes? A critical review of the literature

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