Cited by 74Maternal Mental Health During Pregnancy and PostpartumMaternal and Neonatal HealthcarePregnancy and Medication Impact

Epidemiology of mental disorders during pregnancy and link to birth outcome: a large-scale retrospective observational database study including 38,000 pregnancies

Wallwiener, Stephanie, Goetz, Maren, Lanfer, Anne, Gillessen, Andrea, Suling, Marc, Feisst, Manuel, Sohn, Christof, Wallwiener, Markus·2019·Archives of Gynecology and Obstetrics

Abstract

Purpose To investigate the real-life epidemiology of mental disorders during pregnancy and their impact on birth outcome in an unselected low-risk population in Germany.Methods Claims data of the Techniker Krankenkasse (TK) were analyzed as part of a retrospective observational study over a one-year period from 01/2008 to 12/2008 including 38,174 pregnant women. ICD-10 codes were clustered into four diagnostic groups: depression, anxiety disorders, somatoform/dissociative disorders and acute stress reactions. The relationship between mental disorders, birth mode and infant weight was tested using chi-squared tests and multivariate logistic regression. Main outcome measures included the prevalence of mental disorders during pregnancy, performed cesarean sections and infants born underweight.Results N = 16,639 cases with at least one diagnosis from the four mental disorder diagnostic groups were identified: 9.3% cases of depression, 16.9% cases with an anxiety disorder, 24.2% cases with a somatoform/dissociative disorder, and 11.7% cases of acute stress reactions. Women diagnosed with a mental disorder were more likely to deliver their child by cesarean section ([depression: OR =1.26 (95% CI 1.14-1.39); anxiety: OR 1.11 (95% CI 1.02-1.19); somatoform disorders: OR 1.12 (95% CI 1.05-1.20); acute stress reactions: OR 1.17 (95% CI 1.07-1.28)]. Furthermore, infants of women diagnosed with an ICD-10 code for depression during pregnancy were more likely to be underweight and/or delivered preterm [OR =1.34 (95% CI 1.06-1.69)].Conclusions We observed substantially high prevalence rates of mental disorders during pregnancy which urgently warrant more awareness for validated screening and adequate treatment options.

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Crossref · 10.1007/s00404-019-05075-2

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Authors
Wallwiener, S., Goetz, M., Lanfer, A., Gillessen, A., Suling, M., Feisst, M., Sohn, C., & Wallwiener, M.
Affiliations
  • Heidelberg University (DE)
  • Techniker Krankenkasse (Germany) (DE)
Corresponding author
Wallwiener, Stephanie
Venue
Archives of Gynecology and Obstetrics
Published
2019-02-08
Volume
299
Issue
3
Pages
755-763
ISSN
  • 0003-9128 (ISSN-L)
  • 0932-0067
  • 1432-0711
OpenAlex
W2913934469
Cited by
74
References
66
Citations by year
2026: 5 · 2025: 12 · 2024: 9 · 2023: 18 · 2022: 7 · 2021: 10 · 2020: 9 · 2019: 4
FWCI
6.94
Type
journal article
Language
en
Open access
closed
Locations
  • Archives of Gynecology and Obstetrics (publishedVersion)
  • PubMed (publishedVersion)
Funders
Institute of Women's Health, Tübingen, Germany
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
  • Health Sciences › Health Professions › General Health Professions › Maternal and Neonatal Healthcare
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pregnancy and Medication Impact
Keywords
maternal depression, anxiety disorders, somatoform disorders, dissociative disorders, acute stress response, cesarean section, infant underweight, preterm birth, birth outcomes, prevalence, low-risk pregnancy, mental health screening
MeSH terms
Adult, Anxiety, Mental Disorders, Cesarean Section, Depression, Female, Humans, Mental Health, Pregnancy, Pregnancy Outcome, Retrospective Studies, Risk Factors, Prevalence

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