Cited by 21Pregnancy and preeclampsia studiesNeurological Complications and SyndromesMaternal Mental Health During Pregnancy and Postpartum

RETRACTED ARTICLE: Could 3D placental volume and perfusion indices measured at 11–14 weeks predict occurrence of preeclampsia in high-risk pregnant women?

Hashish, Nawara, Hassan, Ayman, El-Semary, Aly, Gohar, Rovan, Youssef, M. A. F. M.·2015·The Journal of Maternal-Fetal & Neonatal Medicine

Abstract

OBJECTIVE: Preeclampsia (PE) is a known cause of maternal, fetal and neonatal morbidity and mortality. Thus, evaluation of the predicting value of combining the 3D assessment of placental volume with the assessment of placental perfusion indices through 3D power Doppler (3DPD) at 11-14 weeks in pregnant women at high risk to develop PE could be a suitable screening method. METHODS: 3D assessment of placental volume and 3DPD assessment of placental vascularization indices at 11-13 weeks and uterine artery Doppler scan (RI and PI) at 21-22 weeks were conducted in this prospective case-control study. Their predictive ability for PE was assessed. RESULTS: One-hundred pregnant women divided into two groups were enrolled in our study. High-risk group (n = 50) and control group (n = 50). Thirty-eight (76%) patients in the high-risk group and 6.0 (12%) patients in the control group developed PE, respectively. The mean values of placental volume (<0.001), vascularization index (<0.001), vascularization flow index (<0.002) were significantly lower in the high-risk group. Meanwhile, uterine artery RI (0.011) and PI (<0.001) was significantly higher in the study group. Uterine artery PI is negatively correlated with placental volume and vascularization indices (-0.36). CONCLUSION: Our findings suggest that 3D placental volume measurement and 3DPD assessment of placental vascular indices in the first trimester has the potential to detect women at risk for subsequent development of PE.

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Crossref · 10.3109/14767058.2014.943177This paper is marked retracted.

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  • First trimester placental volume and vascularity are linked to adverse pregnancy outcomes including FGR and pre-eclampsia.

    “Both the volume and vascularity of the first trimester placenta has been demonstrated to be linked to adverse pregnancy outcomes including FGR and pre-eclampsia.”
  • Low placental volume (PlaV) at 11-13 weeks is associated with SGA/FGR and pre-eclampsia, independent of PAPP-A and nuchal translucency measurements.

    “It has now been shown that low placental volume (PlaV) at 11–13 weeks is associated with SGA/FGR [23, 26–28] and pre-eclampsia [28, 29], and that this is independent of PAPP-A and nuchal translucency (NT) measurements [27].”

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Authors
Hashish, N., Hassan, A., El-Semary, A., Gohar, R., & Youssef, M. A. F. M.
Affiliations
Cairo University (EG)
Corresponding author
Youssef, M. A. F. M.
Venue
The Journal of Maternal-Fetal & Neonatal Medicine
Published
2014-07-28
Volume
28
Issue
9
Pages
1094-1098
ISSN
  • 1476-4954 (ISSN-L)
  • 1476-7058
OpenAlex
W1981140049
Cited by
21
References
15
Citations by year
2026: 1 · 2025: 2 · 2023: 2 · 2022: 3 · 2021: 3 · 2020: 2 · 2019: 1 · 2018: 3 · 2017: 2 · 2016: 1 · 2015: 1
FWCI
1.42
Type
journal article
Language
en
Status
Retracted
Open access
closed
Locations
  • The Journal of Maternal-Fetal & Neonatal Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
  • Health Sciences › Medicine › Psychiatry and Mental health › Neurological Complications and Syndromes
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
Keywords
preeclampsia, placental volume, placental perfusion, 3D power Doppler, uterine artery Doppler, first-trimester screening, high-risk pregnancy, vascularization index, risk prediction
MeSH terms
Adult, Female, Humans, Placenta, Pre-Eclampsia, Predictive Value of Tests, Pregnancy, Pregnancy Trimester, First, Prospective Studies, Case-Control Studies, Ultrasonography, Prenatal, Imaging, Three-Dimensional, Young Adult, Uterine Artery

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