RETRACTED ARTICLE: Could 3D placental volume and perfusion indices measured at 11–14 weeks predict occurrence of preeclampsia in high-risk pregnant women?
Abstract
OBJECTIVE: Preeclampsia (PE) is a known cause of maternal, fetal and neonatal morbidity and mortality. Thus, evaluation of the predicting value of combining the 3D assessment of placental volume with the assessment of placental perfusion indices through 3D power Doppler (3DPD) at 11-14 weeks in pregnant women at high risk to develop PE could be a suitable screening method. METHODS: 3D assessment of placental volume and 3DPD assessment of placental vascularization indices at 11-13 weeks and uterine artery Doppler scan (RI and PI) at 21-22 weeks were conducted in this prospective case-control study. Their predictive ability for PE was assessed. RESULTS: One-hundred pregnant women divided into two groups were enrolled in our study. High-risk group (n = 50) and control group (n = 50). Thirty-eight (76%) patients in the high-risk group and 6.0 (12%) patients in the control group developed PE, respectively. The mean values of placental volume (<0.001), vascularization index (<0.001), vascularization flow index (<0.002) were significantly lower in the high-risk group. Meanwhile, uterine artery RI (0.011) and PI (<0.001) was significantly higher in the study group. Uterine artery PI is negatively correlated with placental volume and vascularization indices (-0.36). CONCLUSION: Our findings suggest that 3D placental volume measurement and 3DPD assessment of placental vascular indices in the first trimester has the potential to detect women at risk for subsequent development of PE.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
First trimester placental volume and vascularity are linked to adverse pregnancy outcomes including FGR and pre-eclampsia.
“Both the volume and vascularity of the first trimester placenta has been demonstrated to be linked to adverse pregnancy outcomes including FGR and pre-eclampsia.”
From Volume and vascularity: Using ultrasound to unlock the secrets of the first trimester placenta (2019) · cites this paper as [29]
Low placental volume (PlaV) at 11-13 weeks is associated with SGA/FGR and pre-eclampsia, independent of PAPP-A and nuchal translucency measurements.
“It has now been shown that low placental volume (PlaV) at 11–13 weeks is associated with SGA/FGR [23, 26–28] and pre-eclampsia [28, 29], and that this is independent of PAPP-A and nuchal translucency (NT) measurements [27].”
From Volume and vascularity: Using ultrasound to unlock the secrets of the first trimester placenta (2019) · cites this paper as [29]
Cites
Kaufmann, P., Black, S., & Huppertz, B. (2003) · Biology of Reproduction · doi:10.1095/biolreprod.102.014977 · Cited by 1,210 · see citing works
Zhong, Y., Tuuli, M. G., & Odibo, A. O. (2010) · Prenatal Diagnosis · doi:10.1002/pd.2475 · Cited by 137 · see citing works
Hafner, E., Metzenbauer, M., Höfinger, D., Stonek, F., Schuchter, K., Waldhör, T., & Philipp, K. (2006) · Ultrasound in Obstetrics & Gynecology · doi:10.1002/uog.2641 · Cited by 137 · see citing works
Uterine artery Doppler flow studies in obstetric practice
Sciscione, A. C., & Hayes, E. J. (2009) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2009.03.027 · Cited by 114 · see citing works
Placental volume and vascular flow assessed by 3D power Doppler and adverse pregnancy outcomes
Odibo, A. O., Goetzinger, K. R., Huster, K., Christiansen, J. K., Odibo, L., & Tuuli, M. G. (2011) · Placenta · doi:10.1016/j.placenta.2011.01.010 · Cited by 104 · see citing works
Schuchter, K., Metzenbauer, M., Hafner, E., & Philipp, K. (2001) · Ultrasound in Obstetrics and Gynecology · doi:10.1046/j.0960-7692.2001.00596.x · Cited by 95 · see citing works
Placental vascular pathology as a mechanism of disease in pregnancy complications
Kovo, M., Schreiber, L., & Bar, J. (2013) · Thrombosis Research · doi:10.1016/s0049-3848(13)70013-6 · Cited by 88 · see citing works
Rizzo, G., Capponi, A., Pietrolucci, M. E., Capece, A., & Arduini, D. (2009) · Journal of Ultrasound in Medicine · doi:10.7863/jum.2009.28.12.1615 · Cited by 68 · see citing works
Hafner, E., Metzenbauer, M., Stümpflen, I., Waldhör, T., & Philipp, K. (2010) · Placenta · doi:10.1016/j.placenta.2010.06.011 · Cited by 67 · see citing works
Odeh, M., Ophir, E., Maximovsky, O., Grinin, V., & Bornstein, J. (2011) · Prenatal Diagnosis · doi:10.1002/pd.2697 · Cited by 66 · see citing works
Dar, P., Gebb, J. S., Reimers, L., Bernstein, P. S., Chazotte, C., & Merkatz, I. R. (2010) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2010.06.006 · Cited by 59 · see citing works
3-dimensional colour power angiography for staging human placental development
Konje, J. C., Huppertz, B., Bell, S. C., Taylor, D. J., & Kaufmann, P. (2003) · The Lancet · doi:10.1016/s0140-6736(03)14514-x · Cited by 56 · see citing works
Costa, J., Rice, H., Cardwell, C. R., Hunter, A. J., & Ong, S. S. (2010) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.3109/14767051003649862 · Cited by 39 · see citing works
Bujold, E., Effendi, M., Girard, M., Gouin, K., Forest, J., Couturier, B., & Giguère, Y. (2009) · Journal of Obstetrics and Gynaecology Canada · doi:10.1016/s1701-2163(16)34375-4 · Cited by 24 · see citing works
Gebb, J. S., Reimers, L., Merkatz, I. R., Chazotte, C., Bernstein, P. S., & Dar, P. (2009) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.6784 · Cited by 7 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Eastwood, K., Patterson, C. C., Hunter, A. J., McCance, D. R., Young, I. S., & Holmes, V. A. (2017) · Placenta · doi:10.1016/j.placenta.2017.01.005 · Cited by 41 · see citing works
Choux, C., Ginod, P., Barberet, J., Rousseau, T., Bruno, C., Sagot, P., Astruc, K., & Fauque, P. (2018) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2018.12.023 · Cited by 37 · see citing works
Volume and vascularity: Using ultrasound to unlock the secrets of the first trimester placenta
Mathewlynn, S., & Collins, S. L. (2019) · Placenta · doi:10.1016/j.placenta.2019.06.379 · Cited by 30 · see citing works
Abdallah, A. A., Khairy, M., Tawfik, M., Mohamed, S., Rasheed, M. A., Salem, S. M., & Khalifa, E. M. (2020) · International Journal of Gynecology & Obstetrics · doi:10.1002/ijgo.13572 · Cited by 21 · see citing works
RetractedFeto-placental blood vessel development
Kalisch-Smith, J. I. (2025) · Development · doi:10.1242/dev.204838 · Cited by 14 · see citing works
Mulcahy, C., Mone, F., McParland, P., Breathnach, F., Cody, F., Morrison, J. J., Higgins, J., Daly, S., Dornan, S., Cotter, A. M., et al. (2018) · American Journal of Perinatology · doi:10.1055/s-0038-1675208 · Cited by 14 · see citing works
Multiscale and multimodal imaging of utero-placental anatomy and function in pregnancy
Srinivasan, V., Melbourne, A., Oyston, C., James, J. L., & Clark, A. R. (2021) · Placenta · doi:10.1016/j.placenta.2021.07.290 · Cited by 13 · see citing works
New insights into human functional ultrasound imaging
Bertholdt, C., Dap, M., Beaumont, M., Duan, J., & Morel, O. (2021) · Placenta · doi:10.1016/j.placenta.2021.10.005 · Cited by 13 · see citing works
Chen, J., Chen, M., Wu, X. J., Sun, J. M., Zhang, Y., Li, Y. F., Zhong, L. Y., Yu, B. L., Luo, J., & Liu, J. H. (2022) · Placenta · doi:10.1016/j.placenta.2022.03.124 · Cited by 10 · see citing works
Cui, H., Yu, L., Li, H., Wang, H., Liang, W., Wang, H., & Wang, H. (2022) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-022-02530-z · Cited by 10 · see citing works
Turan, O. M., Babischkin, J. S., Aberdeen, G. W., Turan, S., Harman, C. R., Pepe, G. J., & Albrecht, E. D. (2021) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.23753 · Cited by 6 · see citing works
Wang, Y., Zheng, M., Bao, M., & Wang, H. (2025) · Quantitative Imaging in Medicine and Surgery · doi:10.21037/qims-2025-158 · Cited by 5 · see citing works
Turan, O. M., Babischkin, J. S., Aberdeen, G. W., Turan, Ş., Pepe, G. J., & Albrecht, E. D. (2023) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2023.08.021 · Cited by 5 · see citing works
Predictive accuracy of the first trimester Doppler scan: a meta-study
Matevosyan, N. R. (2015) · Wiener Medizinische Wochenschrift · doi:10.1007/s10354-015-0358-5 · Cited by 4 · see citing works
Plazentationsstörungen und feto-maternale Erkrankungen
von Kaisenberg, C. S., & Steiner, H. (2017) · Springer eBooks · doi:10.1007/978-3-662-54966-7_9 · Cited by 2 · see citing works
Zambella, E., Inversetti, A., Pivato, C. A., Cristodoro, M., Stefanini, G. G., & Simone, N. D. (2026) · European Heart Journal - Quality of Care and Clinical Outcomes · doi:10.1093/ehjqcco/qcag020 · Cited by 1 · see citing works
Shaheen, A., Emarh, M., & Magd, H. (2018) · Evidence Based Women s Health Journal · doi:10.21608/ebwhj.2018.15475 · Cited by 1 · see citing works
Abdallah, A. A., Tawfik, M., Mohamed, S., Rasheed, M. A., Salem, S. M., & Khalifa, E. M. (2020) · doi:10.22541/au.158775661.17509945 · Cited by 1 · see citing works
Belal, S., Alsayed, M., Hamid, H. A., & ElBaz, A. (2022) · Evidence Based Women s Health Journal · doi:10.21608/ebwhj.2022.117548.1166
Wasfy, M. A., Negm, M. A., & Hamed, B. M. (2023) · The Egyptian Journal of Hospital Medicine · doi:10.21608/ejhm.2023.283675
- Authors
- Hashish, N., Hassan, A., El-Semary, A., Gohar, R., & Youssef, M. A. F. M.
- Affiliations
- Cairo University (EG)
- Corresponding author
- Youssef, M. A. F. M.
- ORCID
- Youssef, M. A. F. M.
- Venue
- The Journal of Maternal-Fetal & Neonatal Medicine
- Publisher
- Informa UK Limited
- Published
- 2014-07-28
- Volume
- 28
- Issue
- 9
- Pages
- 1094-1098
- ISSN
- 1476-4954 (ISSN-L)
- 1476-7058
- OpenAlex
- W1981140049
- Cited by
- 21
- References
- 15
- Citations by year
- 2026: 1 · 2025: 2 · 2023: 2 · 2022: 3 · 2021: 3 · 2020: 2 · 2019: 1 · 2018: 3 · 2017: 2 · 2016: 1 · 2015: 1
- FWCI
- 1.42
- Type
- journal article
- Language
- en
- Status
- Retracted
- Update notices
- retraction (2026-08-23)
- Open access
- closed
- Locations
- The Journal of Maternal-Fetal & Neonatal Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Psychiatry and Mental health › Neurological Complications and Syndromes
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Keywords
- preeclampsia, placental volume, placental perfusion, 3D power Doppler, uterine artery Doppler, first-trimester screening, high-risk pregnancy, vascularization index, risk prediction
- MeSH terms
- Adult, Female, Humans, Placenta, Pre-Eclampsia, Predictive Value of Tests, Pregnancy, Pregnancy Trimester, First, Prospective Studies, Case-Control Studies, Ultrasonography, Prenatal, Imaging, Three-Dimensional, Young Adult, Uterine Artery
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review