First trimester placental and myometrial blood perfusion measured by 3D power Doppler in normal and unfavourable outcome pregnancies
Abstract
Introduction To evaluate whether 3D placental and myometrial power Doppler blood perfusion in the first trimester can be used to detect risk pregnancies.Methods 3D power Doppler vascularization index (VI) and flow index (FI) of the entire placenta and the neighbouring myometrium were separately measured in the first trimester in all women with singleton pregnancies during a period of three months. In addition we measured placental volume, placental quotient, PAPP-A, as well as uterine artery at 12 and 22 weeks (mean PI and mean notch) and compared those data with the pregnancy outcome.Results Data from 383 women could be evaluated. 10 developed pre-eclampsia (PE). Both flow and vascularization were markedly lower in the placentas compared to the adjoining decidua and myometria. There was some correlation between placental vascularization Index (PVI) as well as deciduo-myometrial vascularization index (MVI) and placental volume, PAPP-A and number of pregnancies and a marked correlation between PVI and especially MVI to mean notch at 12 weeks and 22 weeks (PVI: -0.215, -0.274 MVI: -0.316,-0.322). PVI and MVI were significantly reduced in women with pregnancy problems and showed the greatest reduction in PE-pregnancies (p: 0.0018, 0.0004). Of all measured parameters MVI showed the best sensitivity for the detection of PE.Conclusion The correlation between PVI and MVI in the first trimester and mean notch in the second shows that they provide valuable information at as early as 12 weeks which normally so far is only available at 22 weeks by uterine artery Doppler flow. As MVI measures the percentage of vessels in the deciduo-myometrial area it could also provide information on trophoblast invasion. This hypothesis is supported in particular by a marked decrease of the MVI in pregnancy problems especially in PE-pregnancies.
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First trimester placental volume is associated with adverse pregnancy outcomes, including small-for-gestational-age infants born under the 10th or 5th centiles.
“Early placental volume (PV) has been associated with small-for-gestational-age infants born under the 10th/5th centiles (SGA10/SGA5).”
From Fully Automated Placental Volume Quantification From<scp>3D</scp>Ultrasound for Prediction of Small‐for‐Gestational‐Age Infants (2022) · cites this paper as [5]
Cites
KHONG, T. Y., DE WOLF, F., ROBERTSON, W. B., & BROSENS, I. (1986) · BJOG: An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1986.tb07830.x · Cited by 1,591 · see citing works
Meekins, J. W., Pijnenborg, R., HANSSENS, M. C. A. J. A., McFadyen, I., & van Asshe, A. (1994) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1994.tb13182.x · Cited by 901 · see citing works
Power Doppler US: a potentially useful alternative to mean frequency-based color Doppler US.
Rubin, J. M., Bude, R. O., Carson, P. L., Bree, R. L., & Adler, R. S. (1994) · Radiology · doi:10.1148/radiology.190.3.8115639 · Cited by 864 · see citing works
The physiological response of the vessels of the placental bed to normal pregnancy
Brosens, I. A., Robertson, W. B., & Dixon, H. G. (1967) · The Journal of Pathology and Bacteriology · doi:10.1002/path.1700930218 · Cited by 792 · see citing works
Cnossen, J. S., Morris, R. K., ter Riet, G., Mol, B. W. J., van der Post, J. A. M., Coomarasamy, A., Zwinderman, A. H., Robson, S. C., Bindels, P. J. E., Kleijnen, J., et al. (2008) · Canadian Medical Association Journal · doi:10.1503/cmaj.070430 · Cited by 719 · see citing works
Placental bed spiral arteries in the hypertensive disorders of pregnancy
Pijnenborg, R., Anthony, J., Davey, D. A., Rees, A., Tiltman, A. J., Vercruysse, L., & Assche, A. V. (1991) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1991.tb13450.x · Cited by 667 · see citing works
Martin, A., Bindra, R. R., Curcio, P., Cicero, S., & Nicolaides, K. H. (2001) · Ultrasound in Obstetrics and Gynecology · doi:10.1046/j.0960-7692.2001.00594.x · Cited by 452 · see citing works
Three‐dimensional power Doppler sonography: imaging and quantifying blood flow and vascularization
Pairleitner, H., Steiner, H., Hasenöhrl, G., & Staudach, A. (1999) · Ultrasound in Obstetrics and Gynecology · doi:10.1046/j.1469-0705.1999.14020139.x · Cited by 388 · see citing works
Fractional moving blood volume: estimation with power Doppler US.
Rubin, J. M., Adler, R. S., Fowlkes, J. B., Spratt, S., Pallister, J. E., Chen, J. F., & Carson, P. L. (1995) · Radiology · doi:10.1148/radiology.197.1.7568820 · Cited by 298 · see citing works
Nicolaides, K. H., Bindra, R. R., Turan, O. M., Chefetz, I., Sammar, M., Meiri, H., Tal, J., & Cuckle, H. (2005) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.2686 · Cited by 268 · see citing works
Second-trimester uterine artery Doppler screening in unselected populations: a review
Papageorghiou, A. T., Yu, C.-S., Cicero, S., Bower, S. J., & Nicolaides, K. H. (2002) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/jmf.12.2.78.88 · Cited by 243 · see citing works
Gómez, O., Martínez, J. M., Figueras, F., del Río, M., Borobio, V., Puerto, B., Coll, O., Cararach, V., & Vanrell, J. A. (2005) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.1976 · Cited by 217 · see citing works
Bower, S. J., Schuchter, K., & Campbell, S. C. (1993) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1993.tb15139.x · Cited by 209 · see citing works
Rotchell, Y., Cruickshank, J. K., Gay, M., Griffiths, J. A., Stewart, A., Farrell, B., Ayers, S. E., Hennis, A. J. M., GRANT, A. M., Duley, L., et al. (1998) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1998.tb10088.x · Cited by 197 · see citing works
Pilalis, A., Souka, A. P., Antsaklis, P. J., Daskalakis, G., Papantoniou, N., Mesogitis, S. A., & Antsaklis, A. J. (2007) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.3881 · Cited by 188 · see citing works
Yu, C.-S., Papageorghiou, A. T., Parra, M., Dias, R. P., & Nicolaides, K. H. (2003) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.218 · Cited by 170 · see citing works
Subtil, D., Goeusse, P., Houfflin‐Debarge, V., Puech, F., Lequien, P., Bréart, G., Uzan, S., Quandalle, F., Delcourt, Y. M., Malek, Y. M., et al. (2003) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1046/j.1471-0528.2003.t01-1-02097.x · Cited by 153 · see citing works
Guiot, C., Gaglioti, P. P., Oberto, M., et al. (2008) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.5212 · Cited by 149 · see citing works
Raine‐Fenning, N., Nordin, N. M., Ramnarine, K. V., Campbell, B. K., Clewes, J. S., Perkins, A. C., & Johnson, I. R. (2008) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.6110 · Cited by 147 · see citing works
Hafner, E., Metzenbauer, M., Höfinger, D., Stonek, F., Schuchter, K., Waldhör, T., & Philipp, K. (2006) · Ultrasound in Obstetrics & Gynecology · doi:10.1002/uog.2641 · Cited by 137 · see citing works
Self-citationRaine‐Fenning, N. J., Nordin, N. M., Ramnarine, K. V., Campbell, B. K., Clewes, J. S., Perkins, A. C., & Johnson, I. R. (2008) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.6138 · Cited by 134 · see citing works
de Paula, C. F. S., Ruano, R., Campos, J. Á. D. B., & Zugaib, M. (2008) · Placenta · doi:10.1016/j.placenta.2008.11.010 · Cited by 111 · see citing works
Papageorghiou, A. T., Yu, C.-S., Erasmus, I., Cuckle, H., & Nicolaides, K. H. (2005) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2005.00519.x · Cited by 111 · see citing works
Noguchi, J., Hata, K., Tanaka, H., & Hata, T. (2009) · Placenta · doi:10.1016/j.placenta.2009.02.010 · Cited by 100 · see citing works
Merce, L. T., Barco, M. J., Bau, S., Kupesic, S. P., & Kurjak, A. (2005) · PubMed · Cited by 97 · see citing works
Hafner, E., Philipp, T., Schuchter, K., Dillinger‐Paller, B., Philipp, K., & Bauer, P. (1998) · Ultrasound in Obstetrics and Gynecology · doi:10.1046/j.1469-0705.1998.12020097.x · Cited by 95 · see citing works
Self-citationUterine artery Doppler in the prediction of adverse pregnancy outcome
Papageorghiou, A. T., & Leslie, K. (2007) · Current Opinion in Obstetrics & Gynecology · doi:10.1097/gco.0b013e32809bd964 · Cited by 88 · see citing works
Pilalis, A., Souka, A. P., Antsaklis, P., BASAYIANNIS, K., BENARDIS, P., Haidopoulos, D. A., Papantoniou, N. E., Mesogitis, S. A., & Antsaklis, A. J. (2007) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.1080/00016340601155056 · Cited by 80 · see citing works
Metzenbauer, M., Hafner, E., Schuchter, K., & Philipp, K. (2002) · Ultrasound in Obstetrics & Gynecology · doi:10.1046/j.1469-0705.2002.00655.x · Cited by 79 · see citing works
Self-citationCorrelation of first trimester placental volume and second trimester uterine artery Doppler flow
Hafner, E., Metzenbauer, M., Dillinger-Paller, B., Hoefinger, D., Schuchter, K., Sommer-Wagner, H., & Philipp, K. (2001) · Placenta · doi:10.1053/plac.2001.0721 · Cited by 65 · see citing works
Self-citationEvaluation of volume vascularization index and flow index: a phantom study
Schulten‐Wijman, M. J. N. C., Struijk, P. C., Brezinka, C., et al. (2008) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.6112 · Cited by 63 · see citing works
Todros, T., Ferrazzi, E. M., Arduini, D., et al. (1995) · Journal of Ultrasound in Medicine · doi:10.7863/jum.1995.14.5.343 · Cited by 48 · see citing works
Factors affecting color Doppler energy ultrasound recordings in an in-vitro model
Gudmundsson, S., Valentin, L., PIRHONEN, J. P., Olofsson, P., Dubiel, M., & Maršál, K. (1998) · Ultrasound in Medicine & Biology · doi:10.1016/s0301-5629(98)00031-3 · Cited by 38 · see citing works
Fetomaternal Doppler sonography nomograms.
Ertan, A. K., Hendrik, H. J., Tanriverdi, H. A., et al. (2003) · PubMed · Cited by 26 · see citing works
Leiberman, J. R., Meizner, I., Fraser, D. J., et al. (1994) · International Journal of Gynecology & Obstetrics · doi:10.1016/0020-7292(94)90436-7 · Cited by 6 · see citing works
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Hashish, N., Hassan, A., El-Semary, A., Gohar, R., & Youssef, M. A. F. M. (2015) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.3109/14767058.2014.943177 · Cited by 21 · see citing works
RetractedSchwartz, N., Oguz, I., Wang, J., Pouch, A., Yushkevich, N., Parameshwaran, S., Gee, J., Yushkevich, P., & Oguz, B. (2022) · Journal of Ultrasound in Medicine · doi:10.1002/jum.15835 · Cited by 11 · see citing works
- Authors
- Hafner, E., Metzenbauer, M., Stümpflen, I., Waldhör, T., & Philipp, K.
- Affiliations
- Donauspital (AT)
- University of Vienna (AT)
- Corresponding author
- Hafner, E.
- ORCID
- Metzenbauer, M.
- Venue
- Placenta
- Publisher
- Elsevier BV
- Published
- 2010-09
- Volume
- 31
- Issue
- 9
- Pages
- 756-763
- ISSN
- 0143-4004 (ISSN-L)
- OpenAlex
- W2060299145
- Cited by
- 67
- References
- 36
- Citations by year
- 2026: 1 · 2025: 2 · 2023: 1 · 2022: 3 · 2021: 4 · 2020: 2 · 2018: 7 · 2017: 7 · 2016: 8 · 2015: 6 · 2014: 7 · 2013: 6 · 2012: 1
- FWCI
- 7.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Placenta (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Screening and Diagnostics
- Keywords
- 3D power Doppler, first trimester, preeclampsia prediction, vascularization index, flow index, placental volume, PAPP-A, uterine artery Doppler, decidua, trophoblast invasion, pregnancy outcomes
- MeSH terms
- Adolescent, Adult, Female, Fetal Growth Retardation, Humans, Myometrium, Placenta, Pre-Eclampsia, Pregnancy, Pregnancy Outcome, Pregnancy Trimester, First, Pregnancy-Associated Plasma Protein-A, Uterus, Laser-Doppler Flowmetry, Uterine Artery
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