Umbilical cord blood concentrations of ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) and glial fibrillary acidic protein (GFAP) in neonates developing hypoxic-ischemic encephalopathy
Abstract
OBJECTIVE: To compare ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) and glial fibrillary acidic protein (GFAP) concentrations in umbilical cord blood of neonates who develop Sarnat stage II-III hypoxic-ischemic encephalopathy (HIE) to healthy controls, and to relate the concentrations to the severity of neurology and long-time outcomes. MATERIAL AND METHODS: Cord sera of 15 neonates with HIE II-III and 31 matched controls were analyzed for UCH-L1 and GFAP. Comparisons were performed for cord artery pH, amplitude-integrated electroencephalography (aEEG), stage of HIE, and death or sequelae up to an age of 6 years. Parametric and non-parametric statistics were used with a two-sided p < 0.05 considered significant. RESULTS: Among controls no associations between biomarker concentrations and gestational age, birthweight, length of storage of cord sera and degree of hemolysis were found. No significant differences in biomarker concentrations were found between HIE neonates and controls, and no differences were found with regard to HIE stage, cord acidemia, severity of aEEG changes, or persistent sequelae or death. CONCLUSIONS: No differences in cord blood UCH-L1 and GFAP concentrations were found between HIE neonates and controls, and no associations were found between the biomarker concentrations and the severity of disease, or whether the condition developed into a permanent or fatal injury.
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In a series of neonates with HIE stages 2 and 3, the authors found no differences in cord blood UCH-L1 and GFAP concentrations relative to healthy controls, and no associations of biomarker concentrations with severity of disease or with development of the condition into a permanent or fatal injury.
“We found in a series of neonates with HIE stages 2 and 3 no differences in cord blood UCH-L1 and GFAP concentrations relative to healthy controls, and no associations of biomarker concentrations with severity of disease or with development of the condition into a permanent or fatal injury.124”
From Umbilical cord pH, blood gases, and lactate at birth: normal values, interpretation, and clinical utility. (2023) · cites this paper as [124]
LDH determined early in the course has low or no predictive value.
“temporal blood sampling studies 124,127 indicate that LDH determined early in the course has low or no predictive value.”
From Umbilical cord pH, blood gases, and lactate at birth: normal values, interpretation, and clinical utility. (2023) · cites this paper as [124]
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- Authors
- Zaigham, M., Lundberg, F., Hayes, R., Undén, J., & Olofsson, P.
- Affiliations
- Lund University (SE)
- Banyan Biomarkers (United States) (US)
- Corresponding author
- Olofsson, Per
- Venue
- The Journal of Maternal-Fetal & Neonatal Medicine
- Publisher
- Informa UK Limited
- Published
- 2015-07-02
- Volume
- 29
- Issue
- 11
- Pages
- 1-7
- ISSN
- 1476-4954 (ISSN-L)
- 1476-7058
- OpenAlex
- W1777352419
- Cited by
- 25
- References
- 24
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 3 · 2023: 4 · 2022: 4 · 2021: 1 · 2019: 4 · 2018: 2 · 2017: 1 · 2016: 2 · 2015: 1
- FWCI
- 2.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Maternal-Fetal & Neonatal Medicine (publishedVersion)
- PubMed (publishedVersion)
- Lund University Publications (Lund University) (submittedVersion)
- Funders
- Lunds Universitet
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal Health and Biochemistry
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Fetal and Pediatric Neurological Disorders
- Keywords
- hypoxic-ischemic encephalopathy, UCHL1, glial fibrillary acidic protein, umbilical cord blood, neonatal biomarkers, Sarnat staging, neuroprognostic biomarkers, long-term neurological outcome, amplitude-integrated electroencephalography
- MeSH terms
- Acidosis, Birth Weight, Female, Fetal Blood, Gestational Age, Glial Fibrillary Acidic Protein, Hemolysis, Humans, Infant, Newborn, Male, Specimen Handling, Biomarkers, Case-Control Studies, Hypoxia-Ischemia, Brain, Ubiquitin Thiolesterase
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