Protein S100B in umbilical cord blood as a potential biomarker of hypoxic-ischemic encephalopathy in asphyxiated newborns
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Neonatal hypoxic ischemic encephalopathy (HIE) is a devastating condition resulting from a sustained lack of oxygen during birth. The interest in identifying a relevant biomarker of HIE has thrown into limelight the role of protein S100B as a clinical diagnostic marker of hypoxic brain damage in neonates. To evaluate the diagnostic value of protein S100B, measured in umbilical cord blood immediately after birth, as a useful biomarker in the diagnosis of HIE Sarnat stages II-III as well as a marker for long-term mortality and morbidity. Protein S100B was analyzed in cord blood sampled at birth from 13 newborns later diagnosed with stage II-III HIE and compared with 21 healthy controls. S100B concentrations were related to cord artery pH, amplitude-integrated electroencephalography (aEEG), stage of HIE, and death/sequelae up to an age of 6 years. Both parametric and non-parametric statistics were used with a two-sided P < 0.05 considered significant. The difference in S100B concentration was marginally statistically significant between HIE cases and controls ( P = 0.056). Cord blood acidosis ( P = 0.046), aEEG pattern severity ( P = 0.030), HIE severity ( P = 0.027), and condition at 6-year follow-up (healthy/permanent sequelae/death; P = 0.027) were all related to an increase in S100B concentration. Protein S100B in neonates suffering from HIE stages II-III appeared elevated in umbilical cord blood at birth. The S100B concentrations were positively associated to the severity of disease and the risk of suffering from neurodevelopmental sequelae and even death. • Original study involving 13 neonates affected by hypoxic-ischemic encephalopathy (HIE) compared to 21 healthy controls • Comparison of protein S100B sampled from umbilical cord blood at birth • Investigation of S100B in relation to severity of disease and long-term mortality and morbidity • S100B was found to be elevated in neonates suffering from HIE stages II-III • Elevated S100B was related to the risk of suffering from neurodevelopmental sequelae or death later in life
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In a small series of severely asphyxiated newborns (N=13 with HIE stages 2 and 3, follow-up to age 6-7 years) compared with healthy controls (N=21), the authors found that S100B concentration was related to the severity of encephalopathy and the risk of developing permanent neurologic sequelae or death.
“We collected cord blood immediately after birth and compared it in a small series of severely asphyxiated newborns (N¼13 with HIE stages 2 and 3, follow-up to age of 6e7 years) with that of healthy controls (N¼21) and found that the S100B concentration was related to the severity of encephalopathy and the risk of developing permanent neurologic sequelae or death.115”
From Umbilical cord pH, blood gases, and lactate at birth: normal values, interpretation, and clinical utility. (2023) · cites this paper as [115]
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Intermittent Hypoxemia and Brain Injury Biomarker S100B in Preterm InfantsPreprint
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- Authors
- Zaigham, M., Lundberg, F., & Olofsson, P.
- Affiliations
- Lund University (SE)
- Corresponding author
- Zaigham, Mehreen
- Venue
- Early Human Development
- Publisher
- Elsevier BV
- Published
- 2017-09
- Volume
- 112
- Pages
- 48-53
- ISSN
- 0378-3782 (ISSN-L)
- OpenAlex
- W2741495818
- Cited by
- 45
- References
- 53
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 1 · 2023: 7 · 2022: 4 · 2021: 7 · 2020: 3 · 2019: 9 · 2018: 6 · 2017: 1
- FWCI
- 5.69
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Early Human Development (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Lund University Publications (Lund University) (submittedVersion)
- Funders
- Lunds Universitet
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › S100 Proteins and Annexins
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Neonatal and Maternal Infections
- Keywords
- S100B, hypoxic-ischemic encephalopathy, umbilical cord blood, neonatal biomarkers, perinatal asphyxia, amplitude-integrated electroencephalography, neurodevelopmental sequelae, neonatal mortality, hypoxic brain injury, long-term outcome prediction
- MeSH terms
- Adult, Asphyxia Neonatorum, Female, Fetal Blood, Humans, Infant, Newborn, Male, Biomarkers, Hypoxia-Ischemia, Brain, S100 Calcium Binding Protein beta Subunit
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