Enhancement of alcohol withdrawal convulsions in mice by haloperidol
Abstract
Based on the data presented here and the clinical observations cited it would appear that although haloperidol has been used with a certain degree of success for the treatment of acute alcohol abstinence the authors would like to caution the clinician against widespread use of heloperidol for treatment of alcohol withdrawal. In experimentally induced ethanol withdrawal, chlordiazepoxide appears to be a more effective and safer agent for ameliorating symptoms associated with excitation such as tremor, insomnia, anxiety, and hyperexcitability. A double blind comparative clinical investigation between chlordiazepoxide and haloperidol for treatment of alcohol withdrawal is warranted.
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Use of antipsychotics, specifically haloperidol, is recommended only in combination with benzodiazepines, particularly in ICU and for patients experiencing DTs or those with comorbid psychotic disorders.
“The use of antipsychotics, specifically haloperidol, is recommended only in combination with benzodiazepines, particularly in ICU and for patients experiencing DTs or those with comorbid psychotic disorders [42,43].”
From A Narrative Review of Current and Emerging Trends in the Treatment of Alcohol Use Disorder (2024) · cites this paper as [43]
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Managing alcohol withdrawal in the elderly
Kraemer, K. L., Conigliaro, J., & Saitz, R. (1999) · Drugs & Aging · doi:10.2165/00002512-199914060-00002 · Cited by 53 · see citing works
Propofol for Treatment of Refractory Alcohol Withdrawal Syndrome: A Review of the Literature
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A Narrative Review of Current and Emerging Trends in the Treatment of Alcohol Use Disorder
Celik, M., Gold, M. S., & Fuehrlein, B. (2024) · Brain Sciences · doi:10.3390/brainsci14030294 · Cited by 25 · see citing works
Faustmann, T. J., Paschali, M., Kojda, G., Schilbach, L., & Kamp, D. (2025) · Fortschritte der Neurologie · Psychiatrie · doi:10.1055/a-2029-6387 · Cited by 4 · see citing works
- Authors
- Blum, K., Eubanks, J. D., Wallace, J. E., & Hamilton, H.
- Affiliations
- The University of Texas at San Antonio Health Science Center (US)
- ORCID
- Blum, Kenneth
- Venue
- Clinical Toxicology
- Publisher
- Informa UK Limited
- Published
- 1976-01
- Volume
- 9
- Issue
- 3
- Pages
- 427-434
- ISSN
- 0009-9309 (ISSN-L)
- OpenAlex
- W2166055854
- Cited by
- 44
- References
- 16
- Citations by year
- 2024: 2 · 2023: 1 · 2022: 1 · 2020: 1 · 2018: 2 · 2017: 3 · 2016: 3 · 2014: 1 · 2013: 3 · 2012: 2
- FWCI
- 1.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Toxicology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Neurology › Alcoholism and Thiamine Deficiency
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Keywords
- alcohol withdrawal, haloperidol, chlordiazepoxide, ethanol withdrawal, convulsions, antipsychotic drugs, benzodiazepines, drug interactions, tremor, insomnia, anxiety, hyperexcitability
- MeSH terms
- Ethanol, Animals, Chlordiazepoxide, Haloperidol, Humans, Seizures, Substance Withdrawal Syndrome, Time Factors, Mice
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