Suppression of ethanol withdrawal by dopamine
Abstract
An ethanol-inhalation technique was used to determine a potential relationship between dopamine and central nervous effects produced by alcohol. Both L-DOPA and intracranially injected dopamine resulted in attenuation of ethanol-induced withdrawal convulsion scores, whereas, haloperidol, a known dopaminergic blocker was found to significantly increase convulsion scores.
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Foundational research from the 1970s and 1980s, prior to completion of the Human Genome Project, established dopamine's pivotal role in substance-related pharmacodynamics, including alcohol and cocaine dependence.
“Notably, foundational research from the 1970s and 1980s, prior to completion of the Human Genome Project, established dopamine’s pivotal role in substance-related pharmacodynamics, including alcohol and cocaine dependence.22,23”
From Beyond Stigma–Integrating Neurobiology, Genetics, and Awareness Integration Theory in Addiction Recovery (2026) · cites this paper as [22]
Cites
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Self-citation5-Hydroxytryptophol: Evidence for its having physiological properties
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Self-citationEffects of catecholamine synthesis inhibition on ethanol narcosis in mice.
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Self-citationEthanol narcosis in mice: Serotonergic involvement
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Blum, K. (2013) · Journal of Addiction Research & Therapy · doi:10.4172/2155-6105.1000139 · Cited by 73 · see citing works
Self-citationBlum, K., Thompson, B., Demotrovics, Z., Femino, J., Giordano, J., Oscar-Berman, M., Teitelbaum, S., Smith, D. E., Roy, A. K., Agan, G., et al. (2015) · Journal of Reward Deficiency Syndrome · doi:10.17756/jrds.2015-008 · Cited by 73 · see citing works
Self-citationEnhancement of alcohol withdrawal convulsions in mice by haloperidol
Blum, K., Eubanks, J. D., Wallace, J. E., & Hamilton, H. (1976) · Clinical Toxicology · doi:10.3109/15563657608988141 · Cited by 44 · see citing works
Self-citationGold, M. S., Blum, K., Bowirrat, A., Pinhasov, A., Bagchi, D., A. Dennen, C., K. Thanos, P., Hanna, C., Lewandrowski, K.-U., Sharafshah, A., et al. (2024) · INNOSC Theranostics and Pharmacological Sciences · doi:10.36922/itps.1918 · Cited by 9 · see citing works
Self-citationBlum, K., Gold, M., Jafari, N., Lewandrowski, K.-U., Sharafshah, A., Mohankumar, K., Lorio, M., Bowirrat, A., Pinhasov, A., Thanos, K., et al. (2026) · Psychology Research and Behavior Management · doi:10.2147/prbm.s561157 · Cited by 1 · see citing works
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- Authors
- Blum, K., Eubanks, J. D., Wallace, J. E., & Schwertner, H. A.
- Affiliations
- The University of Texas at San Antonio Health Science Center (US)
- Venue
- Experientia
- Published
- 1976-04
- Volume
- 32
- Issue
- 4
- Pages
- 493-495
- ISSN
- 1420-682X (ISSN-L)
- 0014-4754
- 1420-9071
- OpenAlex
- W1991925584
- Cited by
- 48
- References
- 22
- Citations by year
- 2026: 2 · 2024: 2 · 2023: 2 · 2022: 2 · 2018: 1 · 2017: 1 · 2016: 2 · 2015: 1 · 2014: 1 · 2013: 1
- FWCI
- 2.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Cellular and Molecular Life Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Neurology › Alcoholism and Thiamine Deficiency
- Keywords
- ethanol withdrawal, dopamine, L-DOPA, haloperidol, convulsions, dopaminergic blockade, intracerebral injection
- MeSH terms
- Ethanol, Animals, Dopamine, Haloperidol, Humans, Levodopa, Seizures, Substance Withdrawal Syndrome, Time Factors, Mice
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