The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Organ biodistribution, clearance, and genotoxicity of orally administered zinc oxide nanoparticles in mice
Abstract
Abstract Understanding tissue biodistribution and clearance of zinc oxide nanoparticles (ZnO-NPs) is necessary for its risk assessment. Both fed and intraperitoneally injected ZnO-NPs (2.5 g/kg) were absorbed into circulation (within 30 min post-dosing), then biodistributed to the liver, spleen, and kidney. Intraperitoneally injected ZnO-NPs remained in serum for 72 h and could more effectively spread to the heart, lung, and testes, whereas the clearance for fed ZnO-NPs in serum began 6 h after oral administration. Compared with zinc oxide microparticles (ZnO-MPs), ZnO-NPs exhibited much higher absorptivity and tissue biodistribution in fed treatment. A greater fraction of fed ZnO-NPs localised in the liver resulted in transient histopathological lesions. However, superoxide generation and cytotoxicity were showed in vitro treatment with ZnO-NPs (above 20 μg/mL). Considering both in vitro and in vivo data, the ZnO-NPs induced acute liver toxicity which was in compliance with its absorption, biodistribution, and clearance.
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Ultrafine particulate pollutants induce oxidative stress and mitochondrial damage
Li, N., Sioutas, C., Cho, A., Schmitz, D., Misra, C., Sempf, J., Wang, M., Oberley, T., Froines, J., & Nel, A. (2003) · Environmental Health Perspectives · doi:10.1289/ehp.6000 · Cited by 2,097
Cytotoxicity and oxidative stress induced by different metallic nanoparticles on human kidney cells
Pujalté, I., Passagne, I., Brouillaud, B., Tréguer, M., Durand, E., Ohayon-Courtès, C., & L'Azou, B. (2011) · Particle and Fibre Toxicology · doi:10.1186/1743-8977-8-10 · Cited by 398
Cited by
A review of mammalian toxicity of ZnO nanoparticles
Vandebriel, R., & De Jong, W. (2012) · Nanotechnology, Science and Applications · doi:10.2147/nsa.s23932 · Cited by 494
Mao, B.-H., Chen, Z.-Y., Wang, Y.-J., & Yan, S.-J. (2018) · Scientific Reports · doi:10.1038/s41598-018-20728-z · Cited by 319
Sun, Q., Li, J., & Le, T. (2018) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.8b03210 · Cited by 265
Manufactured nanomaterials: categorization and approaches to hazard assessment
Gebel, T., Foth, H., Damm, G., Freyberger, A., Kramer, P.-J., Lilienblum, W., Röhl, C., Schupp, T., Weiss, C., Wollin, K.-M., et al. (2014) · Archives of Toxicology · doi:10.1007/s00204-014-1383-7 · Cited by 137
Kumari, M., Kumari, S. I., Kamal, S. S. K., & Grover, P. (2014) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2014.09.009 · Cited by 64
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Metadata
- Authors
- Li, C.-H., Shen, C.-C., Cheng, Y.-W., Huang, S.-H., Wu, C.-C., Kao, C.-C., Liao, J.-W., & Kang, J.-J.
- Venue
- Nanotoxicology
- Publisher
- Informa UK Limited
- Published
- 2011-09-27
- Volume
- 6
- Issue
- 7
- Pages
- 746-756
- ISSN
- 1743-5390 (ISSN-L)
- 1743-5404
- OpenAlex
- W1982566906
- Cited by
- 244
- References
- 2
- FWCI
- 6.20
- Type
- journal article
- Language
- en
- Open access
- closed
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- Li, C.-H., Shen, C.-C., Cheng, Y.-W., Huang, S.-H., Wu, C.-C., Kao, C.-C., Liao, J.-W., & Kang, J.-J. (2012). Organ biodistribution, clearance, and genotoxicity of orally administered zinc oxide nanoparticles in mice. Nanotoxicology. https://doi.org/10.3109/17435390.2011.620717
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