The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
The antibacterial effects of silver, titanium dioxide and silica dioxide nanoparticles compared to the dental disinfectant chlorhexidine on Streptococcus mutans using a suite of bioassays
Open accessAbstract
Metal-containing nanomaterials have the potential to be used in dentistry for infection control, but little is known about their antibacterial properties. This study investigated the toxicity of silver (Ag), titanium dioxide and silica nanoparticles (NPs) against the oral pathogenic species of Streptococcus mutans, compared to the routine disinfectant, chlorhexidine. The bacteria were assessed using the minimum inhibitory concentration assay for growth, fluorescent staining for live/dead cells, and measurements of lactate. All the assays showed that Ag NPs had the strongest antibacterial activity of the NPs tested, with bacterial growth also being 25-fold lower than that in chlorhexidine. The survival rate of bacteria under the effect of 100 mg l(-1) Ag NPs in the media was 2% compared to 60% with chlorhexidine, while the lactate concentration was 0.6 and 4.0 mM, respectively. Silica and titanium dioxide NPs had limited effects. Dialysis experiments showed negligible silver dissolution. Overall, Ag NPs were the best disinfectant and performed better than chlorhexidine. Improvements to the MIC assay are suggested.
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Cites
Photocatalysis on TiO2 Surfaces: Principles, Mechanisms, and Selected Results
Linsebigler, A. L., Lu, G., & Yates, J. T. (1995) · Chemical Reviews · doi:10.1021/cr00035a013 · Cited by 11,575
Determination of minimum inhibitory concentrations
Andrews, J. M. (2001) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/48.suppl_1.5 · Cited by 4,129
Filipe, V., Hawe, A., & Jiskoot, W. (2010) · Pharmaceutical Research · doi:10.1007/s11095-010-0073-2 · Cited by 1,885
Cited by
Khezerlou, A., Alizadeh-Sani, M., Azizi-Lalabadi, M., & Ehsani, A. (2018) · Microbial Pathogenesis · doi:10.1016/j.micpath.2018.08.008 · Cited by 404
Kim, D., Kadam, A., Shinde, S., Saratale, R. G., Patra, J., & Ghodake, G. (2018) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.8749 · Cited by 312
Chen, M. X., Alexander, K. S., & Baki, G. (2016) · Journal of Pharmaceutics · doi:10.1155/2016/5754349 · Cited by 173
Handy, R. D., Ahtiainen, J., Navas, J. M., Goss, G., Bleeker, E. A. J., & von der Kammer, F. (2018) · Environmental Science: Nano · doi:10.1039/c7en01139c · Cited by 18
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Metadata
- Authors
- Besinis, A., De Peralta, T., & Handy, R. D.
- Venue
- Nanotoxicology
- Publisher
- Informa UK Limited
- Published
- 2012-11-15
- Volume
- 8
- Issue
- 1
- Pages
- 1-16
- ISSN
- 1743-5390 (ISSN-L)
- 1743-5404
- OpenAlex
- W2035529058
- Cited by
- 500
- References
- 3
- FWCI
- 6.81
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Besinis, A., De Peralta, T., & Handy, R. D. (2014). The antibacterial effects of silver, titanium dioxide and silica dioxide nanoparticles compared to the dental disinfectant chlorhexidine on Streptococcus mutans using a suite of bioassays. Nanotoxicology. https://doi.org/10.3109/17435390.2012.742935
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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