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Cited by 70Nanoparticles: synthesis and applicationsImmunotoxicology and immune responsesOccupational and environmental lung diseases

Pulmonary response after exposure to inhaled nickel hydroxide nanoparticles: Short and long-term studies in mice

Open access
Gillespie, Patricia A., Kang, Gi Soo, Elder, Alison, Gelein, Robert, Chen, Lu, Moreira, Andre L., Koberstein, Jeffrey, Tchou-Wong, Kam-Meng, Gordon, Terry, Chen, Lung Chi·2010·Nanotoxicology
DOI 10.3109/17435390903470101PMC PMC2922767
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Abstract

Short and long-term pulmonary response to inhaled nickel hydroxide nanoparticles (nano-Ni(OH)(2), CMD = 40 nm) in C57BL/6 mice was assessed using a whole body exposure system. For short-term studies mice were exposed for 4 h to nominal concentrations of 100, 500, and 1000 mg/m(3). For long-term studies mice were exposed for 5 h/d, 5 d/w, for up to 5 months (m) to a nominal concentration of 100 mg/m(3). Particle morphology, size distribution, chemical composition, solubility, and intrinsic oxidative capacity were determined. Markers of lung injury and inflammation in bronchoalveolar lavage fluid (BALF); histopathology; and lung tissue elemental nickel content and mRNA changes in macrophage inflammatory protein-2 (Mip-2), chemokine ligand 2 (Ccl2), interleukin 1-alpha (Il-1α), and tumor necrosis factor-alpha (Tnf-α) were assessed. Dose-related changes in BALF analyses were observed 24 h after short-term studies while significant changes were noted after 3 m and/or 5 m of exposure (24 h). Nickel content was detected in lung tissue, Ccl2 was most pronouncedly expressed, and histological changes were noted after 5 m of exposure. Collectively, data illustrates nano-Ni(OH)(2) can induce inflammatory responses in C57BL/6 mice.

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  • Ni(OH)2 nanoparticle exposure increases polymorphonuclear leukocytes, macrophages, and lymphocytes in mice.

    “Inflammation was evidenced by increased polymorphonuclear leukocytes (PMN), macrophages, and lymphocytes”

    From Nanoparticles in Construction Materials and Other Applications, and Implications of Nanoparticle Use (2019) · cites this paper as [84]

    The Results (Biological Response; page not available) report significantly increased neutrophil (PMN) and lymphocyte populations after three and five months of exposure. Macrophages were counted, and a marker of their phagocytic activity increased after five months, but the passages do not report an increase in macrophage numbers. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

  • Ni(OH)2 nanoparticle-induced lung damage in mice is reversible due to the lack of severe inflammation indicators.

    “damage was deemed reversible due to the lack of severe inflammation indicators [84].”

    From Nanoparticles in Construction Materials and Other Applications, and Implications of Nanoparticle Use (2019) · cites this paper as [84]

    The Discussion (page unavailable) reports no signs of severe inflammation and says the damage could be reversible at or below the concentration used in the five-month exposures. The claim overstates that qualified suggestion as a determination that the damage was reversible. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

  • Exposure to Ni(OH)2 nanoparticles via aerosol inhalation in mice causes lung inflammation, with a reaction that varies by exposure duration.

    “The findings show that with exposure to Ni(OH)2 nanoparticles lung inflammation ensues, with a varied reaction dependent on the exposure duration.”

    From Nanoparticles in Construction Materials and Other Applications, and Implications of Nanoparticle Use (2019) · cites this paper as [84]

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1 of the 53 references couldn’t be matched to a known paper.

Research works printed but not linked: 3

  1. Dorato MA, 1990, Environ Health Perspect, 85, 163, 10.2307/3430680 · DOI
  2. Potter RM, 1991, Glastech Ber, 84, 16
  3. Sergeev GB, 2006, Nanochemistry, 170

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Authors
Gillespie, P. A., Kang, G. S., Elder, A., Gelein, R., Chen, L., Moreira, A. L., Koberstein, J., Tchou-Wong, K.-M., Gordon, T., & Chen, L. C.
Affiliations
  • New York University (US)
  • University of Rochester Medicine (US)
  • Memorial Sloan Kettering Cancer Center (US)
  • Columbia University (US)
Corresponding author
Chen, Lung Chi
ORCID
Venue
Nanotoxicology
Publisher
Informa UK Limited
Published
2010-01-29
Volume
4
Issue
1
Pages
106-119
ISSN
  • 1743-5390 (ISSN-L)
  • 1743-5404
DOI
10.3109/17435390903470101
PMC
PMC2922767
OpenAlex
W2064676700
Cited by
70
References
53
Citations by year
2024: 3 · 2023: 1 · 2022: 4 · 2021: 8 · 2020: 5 · 2019: 4 · 2018: 1 · 2017: 2 · 2016: 9 · 2015: 4 · 2014: 8 · 2013: 1 · 2012: 9
FWCI
3.30
Type
journal article
Language
en
Open access
Locations
  • Nanotoxicology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • U.S. Environmental Protection Agency
  • National Institutes of Health
  • School of Medicine, New York University
  • National Cancer Institute (R01CA134218)
  • National Institute of Environmental Health Sciences (R43ES015439, R44ES015439, P30ES001247, T32ES007324)
Topics
  • Physical Sciences › Materials Science › Materials Chemistry › Nanoparticles: synthesis and applications
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Occupational and environmental lung diseases
Keywords
nickel hydroxide nanoparticles, nanoparticle inhalation, pulmonary toxicity, lung inflammation, lung injury, bronchoalveolar lavage fluid, CXCL2, MCP-1, interleukin-1 alpha, TNF-α, lung histopathology, C57BL/6 mice, long-term exposure

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