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Cited by 9Systemic Sclerosis and Related DiseasesStress Responses and CortisolPsychosomatic Disorders and Their Treatments

Functional disturbance of the stress-adaptation system in patients with scleroderma

Matsuura, Emi, Ohta, Akihide, Suematsu, Rie, Inoue, Hisako, Koarada, Syuichi, Tada, Yoshifumi, Sherriff-Tadano, Ryoko, Kuroki, Tsukasa +2 more·2011·Modern Rheumatology
DOI 10.3109/s10165-010-0412-5
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Abstract

There have been several reports indicating the association between recent stress experiences and the onset or the exacerbation of rheumatic diseases, although few such reports exist in patients with scleroderma (SSc). The present study was performed to elucidate whether there were any functional disturbances in the neuro-endocrine-immune system as a homeostatic system upon stress in SSc patients. Various serum levels of stress-related hormones and cytokines were examined before and after a mental calculation stress test, and a basal questionnaire study of sense of coherence (SOC, which is related to the ability to cope with stress), recent stress experiences, and quality of life (QOL) was performed in 17 SSc patients and in 38 healthy volunteers. Physical QOL state was impaired in patients, but there were no differences in recent stress experiences and SOC scores between patients and controls. Basal serum cortisol levels were similar in patients and controls, but increased levels of proinflammatory cytokine and noradrenalin were seen in SSc patients. Characteristically, contrary to the control group, whose cortisol levels increased significantly following the mental calculation stress test, no significant increase was observed in the patients when post-test cortisol levels were compared to pre-test levels, suggesting a defect in the normal cortisol response upon stress in SSc patients. The present results suggest that there may be impaired function of the neuro-endocrine-immune system upon stress in SSc patients.

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Crossref · 10.3109/s10165-010-0412-5

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  • Basal cortisol, androstenedione, DHEA-S, and 17-hydroxyprogesterone levels in systemic sclerosis patients do not differ from healthy controls.

    “Basal levels of cortisol, androstenedione, DHEA-S and 17-hydroxyprogesterone in patients with SSc do not differ from healthy controls [253, 254].”

    From Steroidogenesis in the skin: Implications for local immune functions (2013) · cites this paper as [253]

  • Systemic sclerosis patients have a diminished cortisol response to stress or hypoglycemia.

    “They also have a diminished response to a stress test or hypoglycemia, i.e. their level of cortisol does not increase [253, 254].”

    From Steroidogenesis in the skin: Implications for local immune functions (2013) · cites this paper as [253]

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Authors
Matsuura, E., Ohta, A., Suematsu, R., Inoue, H., Koarada, S., Tada, Y., Sherriff-Tadano, R., Kuroki, T., Ikeda, D., & Nagasawa, K.
Affiliations
  • Saga University (JP)
  • International University of Health and Welfare (JP)
  • Hiroshima University (JP)
  • Kyushu University Hospital (JP)
Corresponding author
Matsuura, Emi
ORCID
Venue
Modern Rheumatology
Publisher
Oxford University Press (OUP)
Published
2011-08
Volume
21
Issue
4
Pages
397-405
ISSN
  • 1439-7595 (ISSN-L)
  • 1439-7609
DOI
10.3109/s10165-010-0412-5
OpenAlex
W2010042544
Cited by
9
References
22
Citations by year
2024: 1 · 2023: 2 · 2016: 1 · 2014: 1 · 2013: 2 · 2012: 1
FWCI
1.12
Type
journal article
Language
en
Open access
closed
Locations
  • Modern Rheumatology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Japan Society for the Promotion of Science (21592758, 22792209)
Topics
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Systemic Sclerosis and Related Diseases
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
Keywords
systemic sclerosis, stress response, neuroendocrine-immune network, cortisol, inflammatory cytokines, norepinephrine, sense of coherence, quality of life, stress hormones
MeSH terms
Adaptation, Psychological, Adult, Aged, Aged, 80 and over, Female, Hormones, Humans, Hydrocortisone, Hypothalamo-Hypophyseal System, Male, Middle Aged, Pituitary-Adrenal System, Quality of Life, Surveys and Questionnaires, Scleroderma, Systemic, Stress, Psychological, Biomarkers, Cytokines

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