Effect of electronic cigarettes on smoking reduction and cessation in Korean male smokers: a randomized controlled study.
Open accessAbstract
INTRODUCTION: New approaches to electronic cigarettes (e-cigarettes) as a form of nicotine replacement therapy (NRT) may reduce the rates of tobacco-related disease and mortality. Therefore, we investigated the effect of e-cigarettes on smoking cessation compared with nicotine gum. METHODS: A total of 150 subjects were randomly assigned to 2 groups and each was allocated a 12-week supply of either e-cigarettes or nicotine gum. The continuous abstinence rate, 7-day point prevalence of abstinence, smoking reduction rate and amount, and tolerability were evaluated. RESULTS: There were no statistically significant differences in the effectiveness-related parameters of smoking cessation, such as 9- to 12-week, 9- to 24-week, and 12- and 24-week point prevalence of abstinence, between the 2 groups. However, although the reduction in cigarette smoking was similar, the proportion of subjects who showed smoking reduction at 24 weeks was higher in the e-cigarette group than the nicotine gum group. In addition, adverse events were significantly less frequent in the e-cigarette group than in the nicotine gum group. CONCLUSIONS: In our study, the effect of e-cigarettes on smoking cessation was similar compared with that of nicotine gum, a well-documented NRT. In addition, e-cigarettes were well tolerated by the study population. Therefore, the use of e-cigarettes as an NRT may be considered for smoking-cessation purposes. A large-scale prospective randomized controlled trial is necessary to clarify our results.
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In two of the five trials (n=2008), smokers randomized to e-cigarettes containing nicotine (with or without the co-use of NRT) were found to have statistically significantly greater rates of abstinence than those randomized to NRT alone or NRT plus non-nicotine e-cigarettes at 6- to 12-months follow-up.
“In two of the five trials (n=2008), smokers randomized to e-cigarettes containing nicotine (with or without the co-use of NRT) were found to have statistically significantly greater rates of abstinence than those randomized to NRT alone156 or NRT plus non-nicotine e-cigarettes[87](#R87) at 6- to 12-months follow-up.”
From Interventions for Tobacco Cessation in Adults, Including Pregnant Persons (2021) · cites this paper as [87]
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- Authors
- Lee, S.-H., Ahn, S.-H., & Cheong, Y.-S.
- Affiliations
- Seoul National University (KR)
- Venue
- The Journal of the American Board of Family Medicine
- Published
- 2019-07
- Volume
- 32
- Issue
- 4
- Pages
- 567-574
- ISSN
- 1557-2625 (ISSN-L)
- 1558-7118
- OpenAlex
- W2959208516
- Semantic Scholar
- 496e4ccd957660b3b264ccbf5a74a0194a64d5c4
- Cited by
- 76
- References
- 26
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 15 · 2023: 11 · 2022: 9 · 2021: 17 · 2020: 9 · 2019: 2 · 2016: 1 · 2012: 1
- FWCI
- 6.36
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- The Journal of the American Board of Family Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Keywords
- electronic cigarettes, smoking cessation, nicotine replacement therapy, nicotine gum, smoking reduction, abstinence rates, tolerability, adverse events, male smokers
- MeSH terms
- Tobacco Smoking, Nicotine Chewing Gum, Smoking Reduction, Smokers, Adult, Humans, Male, Middle Aged, Prospective Studies, Smoking Cessation, Treatment Outcome, Republic of Korea, Electronic Nicotine Delivery Systems
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