The DOI matches its Crossref record; 48 of the 50 references it cites were found in a registry or an index.
Structural changes of bovine milk fat globules during in vitro digestion
Open accessAbstract
An in vitro digestion model that simulated gastric and intestinal fasting conditions was used to monitor the physical, chemical, and structural changes of fat globules from raw bovine milk. During in vitro gastric digestion, the fat globules were stable under low-acidic conditions. Some peptides and β-lactoglobulin were resistant to proteolysis by pepsin. Phospholipids, proteins, and peptides stabilized the globules in the stomach model. During in vitro intestinal digestion, most of the β-lactoglobulin and residual peptides were hydrolyzed by trypsin and chymotrypsin, and the lipolytic products, released from the hydrolysis of the triglyceride core of the globules, led to destabilization and coalescence of the globules. By accumulating at the surface of the fat globules, the lipolytic products formed a lamellar phase and their solubilization by bile salts resulted in the formation of disk-shaped micelles. This study brings new interesting insights on the digestion of bovine milk.
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Metadata
- Authors
- Gallier, S., Ye, A., & Singh, H.
- Affiliations
- Riddet Institute (NZ)
- Corresponding author
- Gallier, S.
- ORCID
- Venue
- Journal of Dairy Science
- Publisher
- American Dairy Science Association
- Published
- 2012-07
- Volume
- 95
- Issue
- 7
- Pages
- 3579-3592
- ISSN
- 0022-0302 (ISSN-L)
- OpenAlex
- W1972070675
- Cited by
- 151
- References
- 50
- Citations by year
- 2026: 9 · 2025: 16 · 2024: 10 · 2023: 13 · 2022: 9 · 2021: 20 · 2020: 13 · 2019: 8 · 2018: 6 · 2017: 7 · 2016: 13 · 2015: 9 · 2014: 6 · 2013: 8 · 2012: 3
- FWCI
- 12.79
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Dairy Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Tertiary Education Commission
- Ministry of Education- New Zealand
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Proteins in Food Systems
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Ruminant Nutrition and Digestive Physiology
- Life Sciences › Agricultural and Biological Sciences › Food Science › Animal Diversity and Health Studies
- Keywords
- in vitro digestion, gastric digestion, intestinal digestion, β-lactoglobulin, pepsin resistance, trypsin hydrolysis, chymotrypsin hydrolysis, lipolysis, micelles, bile salts, phospholipids, peptides, fat globule structure
- MeSH terms
- Animals, Cattle, Chymotrypsin, Digestion, Glycolipids, Glycoproteins, Lactoglobulins, Lipolysis, Micelles, Milk Proteins, Trypsin, Microscopy, Confocal, Proteolysis, Lipid Droplets, In Vitro Techniques
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