Short communication: Effects of meloxicam administration on protein metabolism and growth performance in transported Jersey calves
Open accessAbstract
Our objective was to investigate the effects of administering the nonsteroidal anti-inflammatory drug meloxicam (MEL) before transport on various indicators of protein metabolism and growth performance over the first 96 h after transport in Jersey calves. Calves (age ± SD; 2 ± 1 d) sourced from a commercial farm were randomly administered, at 1 mg/kg of body weight, either meloxicam (MEL; n = 11) or a whey protein placebo (CON; n = 10) orally before transport to a calf facility (669 km; 8.5-h road trip). Calves were weighed and rectal temperature was recorded before departure (0 h), on arrival (8.5 h), and 96 h after arrival. Blood was collected at the same time as calves were weighed, and samples were analyzed for total protein (0-h sample), cortisol (0- and 8.5-h samples), haptoglobin (0- and 96-h samples), and amino acids, 3-methylhistidine, and urea-N (96 h). Milk replacer (MR) intake was recorded on arrival and over the next 4 d. Serum total protein concentration did not differ for CON and MEL calves. Plasma cortisol concentration was similar across treatments at 0 h; however, it was lower for CON than for MEL calves at 8.5 h. Although serum haptoglobin concentration tended to be greater for CON than MEL calves 96 h after transport, 3-methylhistidine and plasma urea-N concentrations did not differ across treatments. Plasma Asp, Asn, Glu, Lys, Met, Ser, and Trp were greater and plasma Arg, Gly, Pro, and Thr concentrations tended to be greater at 96 h after arrival for MEL compared with CON calves. Intake of MR and average daily gain were higher in MEL than in CON calves. In summary, although it had no effect on 3-methylhistidine or urea-N concentrations, administration of MEL before transport tended to reduce haptoglobin concentration, altered the amino acid profile, and was beneficial in preventing a decrease in MR intake and average daily gain in Jersey calves.
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Muscle damage and fatigue, highlighted by increasing levels of haptoglobin and CK, occur following extended periods of transportation.
“For example, muscle damage and fatigue, highlighted by increasing levels of haptoglobin and CK, occur following extended periods of transportation”
From A randomized controlled trial investigating the effect of transport duration and age at transport on surplus dairy calves: Part II. Impact on hematological variables. (2023) · cites this paper as Chibisa et al., 2018
The passage on haptoglobin (section labeled Abstract; page unavailable) says that transportation can increase haptoglobin synthesis and that haptoglobin has been shown to peak about 96 hours after transport in feeder calves. The study did not measure CK or establish muscle damage or fatigue; it describes muscle wasting as a possibility and says its measured indicators did not differ between treatments. (LLM, conf=0.86)
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Perspectives on the Management of Surplus Dairy Calves in the United States and Canada
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BackgroundCharacterizing the literature surrounding transportation of young dairy calves: A scoping review
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“Chibisa et al. noted an increase in haptoglobin concentration and changes in the amino acid profile in Jersey calves post-transport [21].”
The effect of meloxicam on neonatal dairy calves: Immunoglobulin G uptake and preweaning performance
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“As a result, the ability to detect a positive response in milk intake observed by Murray et al. (2015a) and Chibisa et al. (2018) was Clark et al.: MELOXICAM FOR NEONATAL CALVES Journal of Dairy Science Vol. 103 No. 12, 2020 11369 limited (P = 0.04 and P < 0.01, respectively); however,…”
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“Its pharmacological effect is completely opposite to that of active insulin, which can promote glycogenolysis and gluconeogenesis and increase blood glucose concentration [12].”
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“(NSAIDs) are becoming increasingly important [2-4].”
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“…= 0 – 5 d) from a commercial farm near Twin Falls, Idaho, were fed 4 L of colostrum within 3 h of birth and were transported 670 km to the University of Idaho ’ s Palouse Research, Extension, and Education Center, where they were used for a separate study on transport stress (Chibisa et al., 2018).”
MethodAdministration of chromium picolinate and meloxicam alleviates regrouping stress in dairy heifers
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“Based on data from Chibisa et al [21], with 85% confidence and 80% power, 10 animals per treatment group were needed to detect differences.”
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- Authors
- Chibisa, G. E., Vinyard, J. R., & Laarman, A. H.
- Affiliations
- University of Idaho (US)
- Corresponding author
- Chibisa, G.E.
- Venue
- Journal of Dairy Science
- Publisher
- American Dairy Science Association
- Published
- 2018-12
- Volume
- 101
- Issue
- 12
- Pages
- 11435-11440
- ISSN
- 0022-0302 (ISSN-L)
- OpenAlex
- W2893022347
- Cited by
- 13
- References
- 21
- Citations by year
- 2026: 1 · 2024: 3 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 2
- FWCI
- 1.84
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Dairy Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Agriculture
- National Institute of Food and Agriculture
- Topics
- Health Sciences › Veterinary › Small Animals › Animal health and immunology
- Health Sciences › Veterinary › Small Animals › Animal Behavior and Welfare Studies
- Health Sciences › Veterinary › Small Animals › Veterinary Pharmacology and Anesthesia
- Keywords
- meloxicam, nonsteroidal anti-inflammatory drugs, Jersey calves, protein metabolism, amino acid composition, haptoglobin, cortisol, 3-methylhistidine, urea-N, average daily gain, growth performance
- MeSH terms
- Meloxicam, Animals, Anti-Inflammatory Agents, Non-Steroidal, Body Weight, Cattle, Female, Haptoglobins, Hydrocortisone, Male, Proteins, Random Allocation, Stress, Physiological, Transportation
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