Cited by 139Neurological disorders and treatmentsObsessive-Compulsive Spectrum DisordersVagus Nerve Stimulation Research

Chronic electrocorticography for sensing movement intention and closed-loop deep brain stimulation with wearable sensors in an essential tremor patient

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Herron, Jeffrey A., Thompson, Margaret C., Brown, Timothy, Chizeck, Howard J., Ojemann, Jeffrey G., Ko, Andrew L.·2017·Journal of Neurosurgery

Abstract

Deep brain stimulation (DBS) has become a widespread and valuable treatment for patients with movement disorders such as essential tremor (ET). However, current DBS treatment constantly delivers stimulation in an open loop, which can be inefficient. Closing the loop with sensors to provide feedback may increase power efficiency and reduce side effects for patients. New implantable neuromodulation platforms, such as the Medtronic Activa PC+S DBS system, offer important data sources by providing chronic neural sensing capabilities and a means of investigating dynamic stimulation based on symptom measurements. The authors implanted in a single patient with ET an Activa PC+S system, a cortical strip of electrodes on the hand sensorimotor cortex, and therapeutic electrodes in the ventral intermediate nucleus of the thalamus. In this paper they describe the effectiveness of the platform when sensing cortical movement intentions while the patient actually performed and imagined performing movements. Additionally, they demonstrate dynamic closed-loop DBS based on several wearable sensor measurements of tremor intensity.

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Crossref · 10.3171/2016.8.jns16536

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Authors
Herron, J. A., Thompson, M. C., Brown, T., Chizeck, H. J., Ojemann, J. G., & Ko, A. L.
Affiliations
U.S. National Science Foundation (US)
Venue
Journal of Neurosurgery
Published
2017-09
Volume
127
Issue
3
Pages
580-587
ISSN
  • 0022-3085 (ISSN-L)
  • 1933-0693
OpenAlex
W2556228493
Cited by
139
References
14
Citations by year
2026: 5 · 2025: 10 · 2024: 12 · 2023: 17 · 2022: 13 · 2021: 22 · 2020: 22 · 2019: 13 · 2018: 17 · 2017: 8
FWCI
9.52
Type
journal article
Language
en
Open access
Locations
  • Journal of neurosurgery (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Science Foundation (EEC-1 028725, 1028725)
  • U.S. Department of Defense
  • National Defense Science and Engineering Graduate
Topics
  • Health Sciences › Medicine › Neurology › Neurological disorders and treatments
  • Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
  • Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
Keywords
essential tremor, deep brain stimulation, closed-loop stimulation, wearable sensors, ventral intermediate nucleus, movement intention
MeSH terms
Electrocorticography, Electrodes, Equipment Design, Humans, Male, Middle Aged, Movement, Essential Tremor, Intention, Deep Brain Stimulation

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