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Cited by 48Dementia and Cognitive Impairment ResearchIntracerebral and Subarachnoid Hemorrhage ResearchAdvanced MRI Techniques and Applications

Prevalence and Topography of Small Hypointense Foci Suggesting Microbleeds on 3T Susceptibility-Weighted Imaging in Various Types of Dementia

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Uetani, H., Hirai, T., Hashimoto, M., Ikeda, M., Kitajima, M., Sakamoto, F., Utsunomiya, D., Oda, S. +3 more·2013·American Journal of Neuroradiology
DOI 10.3174/ajnr.a3332PMC PMC7964666
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Abstract

BACKGROUND AND PURPOSE: The prevalence and topography of small hypointense foci suggesting microbleeds on 3T SWI in various types of dementia have not been systematically investigated. The purpose of this study was to determine the prevalence and topography of SHF on 3T SWI in patients with different dementia subtypes. MATERIALS AND METHODS: We included 347 consecutive patients (217 women, 130 men; age range, 42-93 years; mean age, 74 years) who attended our memory clinic and underwent 3T SWI. They were divided into 6 groups: subjective complaints, MCI, AD, DLB, VaD, and FTLD. Two neuroradiologists evaluated the number and location of SHF on SWIs. Statistical analyses were performed to evaluate inter- and intragroup differences. RESULTS: Of the 347 patients, 160 (46.1%) exhibited at least 1 small hypointense focus. This was true in 86% with VaD, 54% with DLB, 48% with AD, 41% with MCI, 27% with FTLD, and 22% with subjective complaints. With the subjective complaints group as a reference, the odds ratio adjusted by age, sex, and arterial hypertension was 9.2 (95% CI, 2.0-43.6) for VaD; 5.4 (95% CI, 1.2-24.3) for AD; 3.1 for DLB (95% CI, 1.1-8.8); 2.0 for MCI (95% CI, 0.5-8.1); and 1.5 for FTLD (95% CI, 0.4-5.4). There was a significant lobar predilection for AD, DLB, and FTLD groups (P < .05). CONCLUSIONS: On 3T SWI, patients with VaD, AD, and DLB manifested a high SHF prevalence. In patients with AD, DLB, and FTLD, the SHF exhibited a lobar predilection.

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  • CNS microbleeds reflect loss of cerebrovascular integrity and are found in 25% of individuals with MCI and 45-78% of individuals with early AD without dementia.

    “CNS microbleeds reflect loss of cerebrovascular integrity and are found in 25% of individuals with MCI (669) and 45-78% of individuals with early AD without dementia (83, 208, 246, 452, 476, 529, 604, 702).”

    From Blood-Brain Barrier: From Physiology to Disease and Back (2019) · cites this paper as [604]

    Citation 669 is attached to the 25% MCI figure, not the later AD range. The Conclusions and Table 1 report small hypointense foci suggesting microbleeds in 41% of patients with MCI; the Discussion reports a prior estimate of 20%, not 25%. (LLM, conf=0.88)

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  • The broad range of detection of microbleeds could likely be attributed to the magnet field strength, with clinical strength 1.5 and 3T magnets likely underestimating the incidence of microbleeds compared with the research-grade 7T magnet.

    “This broad range of detection could likely be attributed to the magnet field strength, with clinical strength 1.5 and 3T magnets likely underestimating the incidence of microbleeds compared with the research-grade 7T magnet (83, 246, 452, 530, 604, 669).”

    From Blood-Brain Barrier: From Physiology to Disease and Back (2019) · cites this paper as [604]

    The Discussion (page unavailable in our copy) reports that microbleed depiction is enhanced at 3T and 7T compared with 1.5T, supporting a role for field strength. It does not establish that 3T underestimates incidence relative to 7T or that field strength explains the broad range of detection; the authors note that prevalence at 3T did not rise markedly over a prior 1.5T study and that patient characteristics may have affected the results. (LLM, conf=0.87)

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Cited by

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Authors
Uetani, H., Hirai, T., Hashimoto, M., Ikeda, M., Kitajima, M., Sakamoto, F., Utsunomiya, D., Oda, S., Sugiyama, S., Matsubara, J., & Yamashita, Y.
Affiliations
Kumamoto University (JP)
ORCID
Venue
American Journal of Neuroradiology
Publisher
American Society of Neuroradiology (ASNR)
Published
2012-11-01
Volume
34
Issue
5
Pages
984-989
ISSN
  • 0195-6108 (ISSN-L)
  • 1936-959X
DOI
10.3174/ajnr.a3332
PMC
PMC7964666
OpenAlex
W2136051514
Cited by
48
References
5
Citations by year
2025: 2 · 2024: 1 · 2023: 5 · 2022: 5 · 2021: 3 · 2020: 4 · 2019: 4 · 2018: 5 · 2017: 3 · 2016: 4 · 2015: 7 · 2014: 3 · 2013: 2
FWCI
2.74
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • American Journal of Neuroradiology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Neurology › Intracerebral and Subarachnoid Hemorrhage Research
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
Keywords
microbleeds, susceptibility-weighted imaging, dementia, vascular dementia, Alzheimer's disease, dementia with Lewy bodies, frontotemporal lobar degeneration, mild cognitive impairment, prevalence, cerebral microbleeds
MeSH terms
Adult, Aged, Aged, 80 and over, Brain, Cerebral Hemorrhage, Dementia, Female, Humans, Japan, Magnetic Resonance Imaging, Male, Middle Aged, Sensitivity and Specificity, Reproducibility of Results, Comorbidity, Prevalence, Risk Assessment

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