Categorical and correlational analyses of baseline fluorodeoxyglucose positron emission tomography images from the Alzheimer’s Disease Neuroimaging Initiative (ADNI)
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In mostly small single-center studies, Alzheimer's disease (AD) is associated with characteristic and progressive reductions in fluorodeoxyglucose positron emission tomography (PET) measurements of the regional cerebral metabolic rate for glucose (CMRgl). The AD Neuroimaging Initiative (ADNI) is acquiring FDG PET, volumetric magnetic resonance imaging, and other biomarker measurements in a large longitudinal multi-center study of initially mildly affected probable AD (pAD) patients, amnestic mild cognitive impairment (aMCI) patients, who are at increased AD risk, and cognitively normal controls (NC), and we are responsible for analyzing the PET images using statistical parametric mapping (SPM). Here we compare baseline CMRgl measurements from 74 pAD patients and 142 aMCI patients to those from 82 NC, we correlate CMRgl with categorical and continuous measures of clinical disease severity, and we compare apolipoprotein E (APOE) varepsilon4 carriers to non-carriers in each of these subject groups. In comparison with NC, the pAD and aMCI groups each had significantly lower CMRgl bilaterally in posterior cingulate, precuneus, parietotemporal and frontal cortex. Similar reductions were observed when categories of disease severity or lower Mini-Mental State Exam (MMSE) scores were correlated with lower CMRgl. However, when analyses were restricted to the pAD patients, lower MMSE scores were significantly correlated with lower left frontal and temporal CMRgl. These findings from a large, multi-site study support previous single-site findings, supports the characteristic pattern of baseline CMRgl reductions in AD and aMCI patients, as well as preferential anterior CMRgl reductions after the onset of AD dementia.
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Peripheral insulin resistance also occurs in the central nervous system.
“Peripheral resistance to insulin also occurs in the CNS, as the glucose metabolic rate is reduced in the brains of AD patients in fluorodeoxyglucose positron emission tomography (FDG PET) [118,119].”
From Neuroprotective effect of SGLT2 inhibitors. (2021) · cites this paper as [118]
In Alzheimer's disease patients, the brain glucose metabolic rate is reduced as measured by fluorodeoxyglucose positron emission tomography (FDG PET).
“Peripheral resistance to insulin also occurs in the CNS, as the glucose metabolic rate is reduced in the brains of AD patients in fluorodeoxyglucose positron emission tomography (FDG PET) [118,119].”
From Neuroprotective effect of SGLT2 inhibitors. (2021) · cites this paper as [118]
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- Authors
- Langbaum, J. B. S., Chen, K., Lee, W., Reschke, C., Bandy, D., Fleisher, A. S., Alexander, G. E., Foster, N. L., Weiner, M. W., Koeppe, R. A., Jagust, W. J., & Reiman, E. M.
- Affiliations
- Banner Alzheimer’s Institute (US)
- University of Arizona (US)
- University of California San Diego (US)
- University of Utah (US)
- San Francisco VA Medical Center (US)
- University of Michigan (US)
- University of California, Berkeley (US)
- Translational Genomics Research Institute (US)
- Corresponding author
- Reiman, Eric M.
- ORCID
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2009-05
- Volume
- 45
- Issue
- 4
- Pages
- 1107-1116
- ISSN
- 1053-8119 (ISSN-L)
- PMC
- PMC2886795
- OpenAlex
- W2016228161
- Cited by
- 279
- References
- 59
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 10 · 2023: 6 · 2022: 8 · 2021: 9 · 2020: 8 · 2019: 11 · 2018: 26 · 2017: 14 · 2016: 21 · 2015: 15 · 2014: 22 · 2013: 26 · 2012: 24
- FWCI
- 18.55
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- NeuroImage (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5u01ag024904-10)
- National Institute on Aging (U01-AG-024904, P30AG019610, U19AG010483)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
- Keywords
- Alzheimer's disease, amnestic mild cognitive impairment, FDG-PET, regional cerebral glucose metabolism, posterior cingulate cortex, precuneus, frontal and temporal cortex, disease severity, Mini-Mental State Examination, APOE ε4, ADNI
- MeSH terms
- Aged, Alzheimer Disease, Cerebral Cortex, Cognition Disorders, Female, Humans, Male, Middle Aged, Reference Values, Sensitivity and Specificity, Statistics as Topic, Reproducibility of Results, Radiopharmaceuticals, Fluorodeoxyglucose F18, Positron-Emission Tomography
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