Cerebral amyloid angiopathy in the brains of patients with Alzheimer's disease: The CERAD experience, part XV
Abstract
We studied the frequency, severity, and clinical correlations of cerebral amyloid angiopathy (CAA) in 117 CERAD subjects with autopsy-confirmed AD. Eighty-three percent showed at least a mild degree of amyloid angiopathy. Thirty of 117 brains (25.6%) showed moderate to severe CAA affecting the cerebral vessels in one or more cortical regions. These brains also showed a significantly higher frequency of hemorrhages or ischemic lesions than those of subjects with little or no amyloid angiopathy (43.3% versus 23.0%; odds ratio = 2.6, 95% CI = 1.1 to 6.2) High CAA scores also correlated with the presence of cerebral arteriosclerosis and with older age at onset of dementia. Our findings suggest that factors contributing to non-AD-related vascular pathology (e.g., atherosclerosis) may play a role in amyloid deposition in cerebral vessels in AD.
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There is strong experimental evidence that the APOE isoforms are major determinants of the amount and quality of amyloid-β peptide (Aβ) and amyloid burden in the brain that develops during aging.
“There is strong experimental evidence that the APOE isoforms are major determinants of the amount and quality of amyloid-β peptide (Aβ) and amyloid burden in the brain that develops during aging.15–17”
From AAVrh.10-Mediated APOE2 Central Nervous System Gene Therapy for APOE4-Associated Alzheimer's Disease (2018) · cites this paper as [16]
Neuropathological examination of patient brains harboring APP duplications shows abundant plaque and tangle pathology as well as cerebral amyloid angiopathy (CAA).
“Neuropathological examination of patient brains harboring APP duplications show abundant plaque and tangle pathology as well cerebral amyloid angiopathy (CAA)”
From Genetic architecture of Alzheimer's disease (2020) · cites this paper as [249]
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- Authors
- Ellis, R. J., Olichney, J. M., Thal, L. J., Mirra, S. S., Morris, J. C., Beekly, D., & Heyman, A.
- Affiliations
- University of California San Diego (US)
- Emory University (US)
- Washington University in St. Louis (US)
- University of Washington (US)
- Duke University (US)
- Venue
- Neurology
- Published
- 1996-06
- Volume
- 46
- Issue
- 6
- Pages
- 1592-1596
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2020068741
- Cited by
- 561
- References
- 26
- Citations by year
- 2026: 5 · 2025: 26 · 2024: 18 · 2023: 10 · 2022: 20 · 2021: 38 · 2020: 32 · 2019: 23 · 2018: 17 · 2017: 26 · 2016: 27 · 2015: 30 · 2014: 20 · 2013: 23 · 2012: 17
- FWCI
- 8.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Chinese Academy of Agricultural Sciences
- National Institute on Aging (AG06790, AG05131, P50AG005131, U01AG006790)
- Topics
- Health Sciences › Medicine › Neurology › Intracerebral and Subarachnoid Hemorrhage Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- cerebral amyloid angiopathy, Alzheimer's disease, intracerebral hemorrhage, ischemic lesions, cerebral arteriosclerosis, atherosclerosis, vascular pathology
- MeSH terms
- Aged, Alzheimer Disease, Arteriosclerosis, Brain, Cerebral Hemorrhage, Brain Ischemia, Female, Humans, Hypertension, Male, Middle Aged, Prospective Studies, United States, Comorbidity, Cerebral Amyloid Angiopathy
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