Immunoinflammatory mediators in the pathogenesis of diabetes mellitus
Open accessAbstract
Characterized as a metabolic syndrome with multiple consequences for the lives of patients, diabetes mellitus is also classified as a chronic non-communicable disease of great scope in the world. It is a complex disease, with different points of view, including the relation between inflammatory process, obesity and insulin resistance due to the performance of the various immunoinflammatory mediators - called adipokines - on glycemic homeostasis. Recent studies have precisely addressed this aspect for the development of drugs that assist in the protection of pancreatic ß cells from the damages arising from oxidative stress and inflammatory process, in order to control the hyperglycemic picture, which is characteristic of diabetes mellitus.
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The elevated amount of these components stimulates several signaling pathways such as inhibitor kappa beta kinase beta (IKKβ), Jun N-terminal kinase (JNK), and NF-κB signaling pathways to induce the development of insulin resistance.
“The elevated amount of these components stimulates several signaling pathways such as inhibitor kappa beta kinase beta (IKKβ), Jun N-terminal kinase (JNK), and NF-κB signaling pathways to induce the development of insulin resistance (92, 93).”
From Diabetes and Sarcopenic Obesity: Pathogenesis, Diagnosis, and Treatments (2020) · cites this paper as [93]
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- Authors
- Gomes, B. F., & Accardo, C. D. M.
- Affiliations
- Centro Universitário das Américas (FAM) - São Paulo (BR)
- Corresponding author
- Accardo, Camila de Melo
- Venue
- Einstein (São Paulo)
- Published
- 2019-02-19
- Volume
- 17
- Issue
- 1
- Pages
- eRB4596-eRB4596
- ISSN
- 1679-4508 (ISSN-L)
- 2317-6385
- PMC
- PMC6388724
- OpenAlex
- W2915571323
- Cited by
- 32
- References
- 26
- Citations by year
- 2026: 4 · 2025: 2 · 2023: 2 · 2022: 3 · 2021: 10 · 2020: 7 · 2019: 4
- FWCI
- 4.57
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by
- Locations
- Einstein (São Paulo) (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
- Americanae (AECID Library) (submittedVersion, cc-by-nc)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
- Keywords
- diabetes mellitus, adipokines, insulin resistance, obesity, metabolic syndrome, glycemic homeostasis, pancreatic beta cells, oxidative stress, hyperglycemia, anti-inflammatory agents
- MeSH terms
- Diabetes Mellitus, Humans, Insulin Resistance, Inflammation Mediators
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