Effect of indigestible saccharides on B lymphocyte response of intestinal mucosa and cecal fermentation in rats
Open accessAbstract
The effects of water-soluble and -insoluble indigestible saccharides (IDS) on immune responses of the intestinal tract were studied. Male 4-week-old Sprague Dawley rats were fed for three weeks on diets containing several kinds of IDS at 5%. The results revealed that the proportion of kappa-light chain and IgA-presenting lymphocytes in small intestinal and cecal mucosa differed in increased number depending on the type of IDS. The response of colonic mucosa was not pronounced. The amounts of short-chain fatty acid (SCFA) and lactic acid in the cecal contents of the other test groups except the celfur group tended to be higher than those in the cellulose group, particularly in the lactulose group where many acids showed significant increases. The correlation between the proportion of kappa-light chain and IgA-presenting lymphocytes in the cecal mucosa and lactic acid in the cecal contents was significant, but that between the proportion of both lymphocytes and SCFA was not. Based on the above, we concluded that the oral administration of IDS induces the proliferation of kappa-light chain and IgA-producing B lymphocytes in small intestinal and cecal mucosa, but the degree of response differs depending on the type of IDS. It is thus suggested that IDS are involved in the intestinal immune system of rats.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
SCFAs regulate B-cell function.
“A role for SCFA in the regulation of B-cell function was reported nearly 20 years ago (Kudoh et al., 1998).”
From Understanding the Holobiont: How Microbial Metabolites Affect Human Health and Shape the Immune System (2017) · cites this paper as Kudoh et al., 1998
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The mucosal immune system: from fundamental concepts to vaccine development
McGhee, J. R., Mestecky, J. F., Dertzbaugh, M. T., Eldridge, J. H., Hirasawa, M., & Kiyono, H. (1992) · Vaccine · doi:10.1016/0264-410x(92)90021-b · Cited by 904 · see citing works
Inhibition of Mouse Sarcoma 180 by Polysaccharides from Lentinus edodes (Berk.) Sing.
Chihara, G., MAEDA, Y. Y., Hamuro, J., Sasaki, T., & Fukuoka, F. (1969) · Nature · doi:10.1038/222687a0 · Cited by 665 · see citing works
Effects of short chain fatty acids on a new human colon carcinoma cell line (LIM1215).
Whitehead, R., Young, G. P., & Bhathal, P. S. (1986) · Gut · doi:10.1136/gut.27.12.1457 · Cited by 297 · see citing works
Murray, P. D., McKenzie, D. T., Swain, S. L., & Kagnoff, M. F. (1987) · The Journal of Immunology · doi:10.4049/jimmunol.139.8.2669 · Cited by 256 · see citing works
Davies, M. D., & PARROTT, D. M. V. (1981) · Gut · doi:10.1136/gut.22.6.481 · Cited by 220 · see citing works
A study of the effects of dietary gum arabic in humans
Ross, A., Eastwood, M. A., Brydon, W. G., et al. (1983) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/37.3.368 · Cited by 167 · see citing works
Dietary Fibers Modulate Indices of Intestinal Immune Function in Rats
Lim, B. O., Yamada, K., Nonaka, M., Kuramoto, Y., Hưng, P. V., & Sugano, M. (1997) · Journal of Nutrition · doi:10.1093/jn/127.5.663 · Cited by 161 · see citing works
Relationship of Colonic Luminal Short-Chain Fatty Acids and pH to In Vivo Cell Proliferation in Rats
Lupton, J. R., & Kurtz, P. P. (1993) · Journal of Nutrition · doi:10.1093/jn/123.9.1522 · Cited by 147 · see citing works
Enhancement of Immune Response in Peyer's Patch Cells Cultured with Bifidobacterium breve
Yasui, H., & Ohwaki, M. (1991) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(91)78272-6 · Cited by 108 · see citing works
Yamazaki, S., Machii, K., Tsuyuki, S., Momose, H., Kawashima, T., & Ueda, K. (1985) · PubMed Central · Cited by 83 · see citing works
Kiyono, H., Bienenstock, J., McGhee, J. R., et al. (1992) · PubMed · Cited by 83 · see citing works
The Interaction between Carrageenan and the First Component of Complement
Borsos, T., Rapp, H. J., & Crisler, C. (1965) · The Journal of Immunology · doi:10.4049/jimmunol.94.5.662 · Cited by 80 · see citing works
The Colon in Carbohydrate Malabsorption: Short-Chain Fatty Acids, pH, and Osmotic Diarrhoea
Holtug, K., Clausen, M. R., Hove, H., et al. (1992) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365529209000118 · Cited by 77 · see citing works
Proliferation of lymphocyte subsets in the adult rat: a comparison of different lymphoid organs
Westermann, J., Ronneberg, S., Fritz, F. J., et al. (1989) · European Journal of Immunology · doi:10.1002/eji.1830190619 · Cited by 65 · see citing works
Protective Effect of Bifidobacterium-Monoassociation against Lethal Activity of Escherichia coli
Yamazaki, S., KAMIMURA, H., Momose, H., KAWASHIMA, T., & Ueda, K. (1982) · Bifidobacteria and Microflora · doi:10.12938/bifidus1982.1.1_55 · Cited by 52 · see citing works
Antitumor action of shiitake(Lentinus edodes) fruit bodies orally administered to mice.
Nanba, H., Kanichi, M. O. R. I., TOYOMASU, T., & KURODA, H. (1987) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.35.2453 · Cited by 50 · see citing works
Antitumor mechanisms of orally administered shiitake fruit bodies.
Nanba, H., & KURODA, H. (1987) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.35.2459 · Cited by 40 · see citing works
Eftimiadi, C., Stashenko, P., Tonetti, M. S., et al. (1991) · Oral Microbiology and Immunology · doi:10.1111/j.1399-302x.1991.tb00446.x · Cited by 39 · see citing works
Willson, J. K. V. (1989) · Hematology/Oncology Clinics of North America · doi:10.1016/s0889-8588(18)30565-3 · Cited by 30 · see citing works
Immune Response of Bifidobacterium-Monoassociated Mice
Yamazaki, S., Tsuyuki, S., AKASHIBA, H., KAMIMURA, H., Kimura, M., KAWASHIMA, T., & Ueda, K. (1991) · Bifidobacteria and Microflora · doi:10.12938/bifidus1982.10.1_19 · Cited by 28 · see citing works
Sugawara, I., Ishizaka, S., & Möller, G. (1982) · Immunobiology · doi:10.1016/s0171-2985(82)80066-1 · Cited by 26 · see citing works
Lymphocyte activation by purified carrageenan.
Ishizaka, S., Hasuma, T., Otani, S., et al. (1980) · The Journal of Immunology · doi:10.4049/jimmunol.125.5.2232 · Cited by 24 · see citing works
Rice bran hemicellulose increases the peripheral blood lymphocytes in rats
Takenaka, S., & Itoyama, Y. (1993) · Life Sciences · doi:10.1016/0024-3205(93)90282-8 · Cited by 17 · see citing works
Heterotrophic nitrification by intestinal microorganisms
Gomez, R. F., Tannenbaum, S. R., Savoca, J., Ralt, D., & Rockowitz, N. L. (1980) · Cancer · doi:10.1002/1097-0142(19800315)45:5+ · Cited by 17 · see citing works
YONEYAMA, M., Mandai, T., Aga, H., et al. (1992) · Nippon Eiyo Shokuryo Gakkaishi · doi:10.4327/jsnfs.45.109 · Cited by 16 · see citing works
Isao, N. O. N. O., Ohno, N., OHSAWA, M., et al. (1989) · Journal of Pharmacobio-Dynamics · doi:10.1248/bpb1978.12.581 · Cited by 14 · see citing works
Effect of Dietary Fiber on Intestinal Microflora and Health
Rao, A. V. R. (1995) · Medical Entomology and Zoology · Cited by 10 · see citing works
Quantitative Determination of Volatile Fatty Acids by New Gas Chromatography Method
Hori, K., 花井, 拓., Hashimoto, T., et al. (1992) · Nagoya Medical Journal · Cited by 1 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Gut Microbial Metabolites Fuel Host Antibody Responses
Kim, M., Qie, Y., Park, J., & Kim, C. H. (2016) · Cell Host & Microbe · doi:10.1016/j.chom.2016.07.001 · Cited by 893 · see citing works
“It was observed many years ago that DF intake potentiates IgA responses in rats (Kudoh et al., 1998).”
BackgroundPostler, T. S., & Ghosh, S. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.05.008 · Cited by 876 · see citing works
“Obese individuals share a functionally similar gut microbiome between them, with reduced but still considerable species diversity (Human Microbiome Project Consortium, 2012; Kurokawa et al., 2007; Qin et al., 2010; Turnbaugh et al., 2009).”
BackgroundControl of lymphocyte functions by gut microbiota-derived short-chain fatty acids
Kim, C. H. (2021) · Cellular & Molecular Immunology · doi:10.1038/s41423-020-00625-0 · Cited by 404 · see citing works
- Authors
- KUDOH, K., SHIMIZU, J., WADA, M., TAKITA, T., KANKE, Y., & INNAMI, S.
- Affiliations
- Tokyo University of Agriculture (JP)
- ORCID
- WADA, Masahiro
- Venue
- Journal of Nutritional Science and Vitaminology
- Published
- 1998
- Volume
- 44
- Issue
- 1
- Pages
- 103-112
- ISSN
- 0301-4800 (ISSN-L)
- 1881-7742
- OpenAlex
- W2040211065
- Cited by
- 52
- References
- 28
- Citations by year
- 2026: 2 · 2023: 3 · 2021: 4 · 2019: 1 · 2018: 3 · 2017: 4 · 2016: 3 · 2015: 2 · 2014: 1
- FWCI
- 2.15
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- Journal of Nutritional Science and Vitaminology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Nursing › Nutrition and Dietetics › Food composition and properties
- Keywords
- B cells, kappa light chain, intestinal mucosa, cecal fermentation, short-chain fatty acids, lactic acid, lactulose, cellulose, oral administration, intestinal immunity
- MeSH terms
- Animals, B-Lymphocytes, Cecum, Cellulose, Dietary Carbohydrates, Digestion, Fermentation, Gum Arabic, Immunoglobulin A, Immunoglobulin kappa-Chains, Intestinal Mucosa, Lactulose, Male, Rats, Sprague-Dawley, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
