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Inhibition of .ALPHA.-Glucosidase and .ALPHA.-Amylase by Flavonoids
Open accessAbstract
The inhibitory activity of six groups of flavonoids against yeast and rat small intestinal alpha-glucosidases and porcine pancreatic alpha-amylase was compared, and chemical structures of flavonoids responsible for the inhibitory activity were evaluated. Yeast alpha-glucosidase was potently inhibited by the anthocyanidin, isoflavone and flavonol groups with the IC50 values less than 15 microM. The following structures enhanced the inhibitory activity: the unsaturated C ring, 3-OH, 4-CO, the linkage of the B ring at the 3 position, and the hydroxyl substitution on the B ring. Rat small intestinal alpha-glucosidase was weakly inhibited by many flavonoids, and slightly by the anthocyanidin and isoflavone groups. 3-OH and the hydroxyl substitution on the B ring increased the inhibitory activity. In porcine pancreatic alpha-amylase, luteolin, myricetin and quercetin were potent inhibitors with the IC50 values less than 500 microM. The 2,3-double bond, 5-OH, the linkage of the B ring at the 3 position, and the hydroxyl substitution on the B ring enhanced the inhibitory activity, while 3-OH reduced it.
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Cited by
Dietary polyphenols as potential nutraceuticals in management of diabetes: a review
Bahadoran, Z., Mirmiran, P., & Azizi, F. (2013) · Journal of Diabetes & Metabolic Disorders · doi:10.1186/2251-6581-12-43 · Cited by 594
Proença, C., Freitas, M., Ribeiro, D., Oliveira, E. F. T., Sousa, J. L. C., Tomé, S. M., Ramos, M. J., Silva, A. M. S., Fernandes, P. A., & Fernandes, E. (2017) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756366.2017.1368503 · Cited by 432
Inhibitory kinetics and mechanism of kaempferol on α-glucosidase
Peng, X., Zhang, G., Liao, Y., & Gong, D. (2016) · Food Chemistry · doi:10.1016/j.foodchem.2015.05.088 · Cited by 398
α-Glucosidase and α-amylase inhibitory activities of guava leaves
Wang, H., Du, Y.-J., & Song, H.-C. (2010) · Food Chemistry · doi:10.1016/j.foodchem.2010.03.088 · Cited by 323
SIMÃO, A. A., MARQUES, T. R., MARCUSSI, S., & CORRÊA, A. D. (2017) · Anais da Academia Brasileira de Ciências · doi:10.1590/0001-3765201720160067 · Cited by 44
Metadata
- Authors
- TADERA, K., MINAMI, Y., TAKAMATSU, K., & MATSUOKA, T.
- Venue
- Journal of Nutritional Science and Vitaminology
- Published
- 2006
- Volume
- 52
- Issue
- 2
- Pages
- 149-153
- ISSN
- 0301-4800 (ISSN-L)
- 1881-7742
- OpenAlex
- W1718201877
- Cited by
- 1,040
- References
- 0
- FWCI
- 3.63
- Type
- journal article
- Language
- en
- Open access
- diamond
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- TADERA, K., MINAMI, Y., TAKAMATSU, K., & MATSUOKA, T. (2006). Inhibition of .ALPHA.-Glucosidase and .ALPHA.-Amylase by Flavonoids. Journal of Nutritional Science and Vitaminology. https://doi.org/10.3177/jnsv.52.149
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