Cited by 150Nutrition and Health in AgingAging, Health, and DisabilityFrailty in Older Adults

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Relationship between Serum Albumin Level and Aging in Community-Dwelling Self-Supported Elderly Population

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GOMI, Ikuko, FUKUSHIMA, Hideki, SHIRAKI, Makoto, MIWA, Yoshiyuki, ANDO, Takashi, TAKAI, Kuniyuki, MORIWAKI, Hisataka·2007·Journal of Nutritional Science and Vitaminology

DOI 10.3177/jnsv.53.37

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Abstract

While lower serum albumin concentration is often found in the elderly, a relation between serum albumin and age has not been fully elucidated. We conducted population-based cross-sectional and 5-y longitudinal study to examine the relation. A total of 22,705 male and 40,149 female, aged 65 y and older, living in Gifu, participated in the health check service conducted by Gifu City Medical Association. They were self-supported in the activity of daily living and 3,438 of them were followed up every year from 1999 to 2003. Serum albumin levels decreased with age in both men and women. In the cross-sectional study, median value declined from 4.3 g/dL in males aged 65-69 y to 3.9 g/dL in 90< or = y, and 4.3 g/dL to 4.0 g/dL in females. Incidence of hypoalbuminemia (serum albumin < or =3.5 g/dL) increased in parallel with age from 1.2% (65-69 y) to 6.6% (85-89) in males, and 0.6% to 4.1% in females. In the longitudinal study, regression analysis showed a significant decline in serum albumin of 0.015 g/dL per year (r= -0.716) in males, and 0.012 g/ dL per year (r= -0.794) in females. Relative reduction of serum albumin in 5 y was larger in advanced age; 1.2% in females aged 65-69 y and 3.1% in 85-89 y (p<0.05), but not in males. In conclusion, a fall in serum albumin concentration in community-dwelling, self-supported elderly persons was associated significantly with aging.

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Authors: GOMI, I., FUKUSHIMA, H., SHIRAKI, M., MIWA, Y., ANDO, T., TAKAI, K., & MORIWAKI, H.
Affiliations: Gifu University (JP)
ORCID: FUKUSHIMA, Hideki
ANDO, Takashi
MORIWAKI, Hisataka
Venue: Journal of Nutritional Science and Vitaminology
Publisher: Center for Academic Publications Japan
Published: 2007
Volume: 53
Issue: 1
Pages: 37-42
ISSN: 0301-4800 (ISSN-L)
1881-7742
DOI: 10.3177/jnsv.53.37
OpenAlex: W2087569500
Cited by: 149
References: 25
Citations by year: 2026: 9 · 2025: 14 · 2024: 14 · 2023: 12 · 2022: 17 · 2021: 16 · 2020: 11 · 2019: 8 · 2018: 11 · 2017: 6 · 2016: 4 · 2015: 9 · 2014: 3 · 2013: 3 · 2012: 2
FWCI: 1.78
Type: journal article
Language: en
Open access: diamond
doi.org
Locations: Journal of Nutritional Science and Vitaminology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Aging, Health, and Disability
Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
Keywords: serum albumin, aging, hypoalbuminemia, older adults, community-dwelling older adults, sex differences, nutritional status
MeSH terms: Activities of Daily Living, Age Factors, Aged, Aged, 80 and over, Aging, Analysis of Variance, Community Health Services, Cross-Sectional Studies, Female, Follow-Up Studies, Humans, Japan, Longitudinal Studies, Male, Population Surveillance, Research Design, Residence Characteristics, Serum Albumin, Sex Factors, Biomarkers, Incidence, Linear Models, Hypoalbuminemia

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Relationship between Serum Albumin Level and Aging in Community-Dwelling Self-Supported Elderly Population

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