The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Relationship between Serum Albumin Level and Aging in Community-Dwelling Self-Supported Elderly Population
Open accessAbstract
While lower serum albumin concentration is often found in the elderly, a relation between serum albumin and age has not been fully elucidated. We conducted population-based cross-sectional and 5-y longitudinal study to examine the relation. A total of 22,705 male and 40,149 female, aged 65 y and older, living in Gifu, participated in the health check service conducted by Gifu City Medical Association. They were self-supported in the activity of daily living and 3,438 of them were followed up every year from 1999 to 2003. Serum albumin levels decreased with age in both men and women. In the cross-sectional study, median value declined from 4.3 g/dL in males aged 65-69 y to 3.9 g/dL in 90< or = y, and 4.3 g/dL to 4.0 g/dL in females. Incidence of hypoalbuminemia (serum albumin < or =3.5 g/dL) increased in parallel with age from 1.2% (65-69 y) to 6.6% (85-89) in males, and 0.6% to 4.1% in females. In the longitudinal study, regression analysis showed a significant decline in serum albumin of 0.015 g/dL per year (r= -0.716) in males, and 0.012 g/ dL per year (r= -0.794) in females. Relative reduction of serum albumin in 5 y was larger in advanced age; 1.2% in females aged 65-69 y and 3.1% in 85-89 y (p<0.05), but not in males. In conclusion, a fall in serum albumin concentration in community-dwelling, self-supported elderly persons was associated significantly with aging.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Serum albumin levels decrease with age,318 possibly increasing Aβ deposition in the brain, as albumin is able to sequester Aβ from the blood.319”
From Antiageing strategy for neurodegenerative diseases: from mechanisms to clinical advances (2025) · cites this paper as [318]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Fried, L. P. (1998) · JAMA · doi:10.1001/jama.279.8.585 · Cited by 1,107
Association of serum albumin and mortality risk
Goldwasser, P., & Feldman, J. G. (1997) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(97)00015-2 · Cited by 716
Serum Albumin Level and Physical Disability as Predictors of Mortality in Older Persons
Corti, M.-C. (1994) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1994.03520130074036 · Cited by 672
Serum Albumin Level on Admission as a Predictor of Death, Length of Stay, and Readmission
Herrmann, F. R. (1992) · Archives of Internal Medicine · doi:10.1001/archinte.1992.00400130135017 · Cited by 457
Phillips, A. N., Shaper, A. G., & Whincup, P. H. (1989) · The Lancet · doi:10.1016/s0140-6736(89)92042-4 · Cited by 434
Chima, C. S., Barco, K., DEWITT, M. L. A., Maeda, M., Teran, J. C., & Mullen, K. D. (1997) · Journal of the American Dietetic Association · doi:10.1016/s0002-8223(97)00235-6 · Cited by 314
Health, A. A. B. C. S., Visser, M., Kritchevsky, S. B., Newman, A. B., Goodpaster, B. H., Tylavsky, F. A., Nevitt, M. C., & Harris, T. B. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn.82.3.531 · Cited by 249
Serum albumin is associated with skeletal muscle in elderly men and women
Baumgartner, R., Koehler, K., Romero, L. J., & Garry, P. (1996) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/64.4.552 · Cited by 218
Albumin levels as a predictor of mortality in the healthy elderly
Klonoff-Cohen, H. S., Barrett-Connor, E. L., & Edelstein, S. L. (1992) · Journal of Clinical Epidemiology · doi:10.1016/0895-4356(92)90080-7 · Cited by 210
Greenblatt, D. J. (1979) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1979.tb01715.x · Cited by 205
Research works printed but not linked: 1
- 1989, 2, 1434
Cited by
Sorted by citations
Serum albumin and health in older people: Review and meta analysis
Cabrerizo, S., Cuadras, D., Gómez-Busto, F., Artabe, I. A., Marín-Ciancas, F., & Malafarina, V. (2015) · Maturitas · doi:10.1016/j.maturitas.2015.02.009 · Cited by 581
RONS and Oxidative Stress: An Overview of Basic Concepts
Aranda‐Rivera, A. K., Cruz‐Gregorio, A., Arancibia‐Hernández, Y. L., Cruz, E. Y. H., & Pedraza‐Chaverrí, J. (2022) · Oxygen · doi:10.3390/oxygen2040030 · Cited by 437
Age and sex variation in serum albumin concentration: an observational study.
Weaving, G., Batstone, G. F., & Jones, R. G. (2016) · Annals of Clinical Biochemistry: International Journal of Laboratory Medicine · doi:10.1177/0004563215593561 · Cited by 229
Serum copper to zinc ratio: Relationship with aging and health status
Malavolta, M., Piacenza, F., Basso, A., Giacconi, R., Costarelli, L., & Mocchegiani, E. (2015) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2015.01.004 · Cited by 230
Farag, C. M., Antar, R. M., Akosman, S., Ng, M., & Whalen, M. J. (2023) · Oncotarget · doi:10.18632/oncotarget.28367 · Cited by 223
Metadata
- Authors
- GOMI, I., FUKUSHIMA, H., SHIRAKI, M., MIWA, Y., ANDO, T., TAKAI, K., & MORIWAKI, H.
- Affiliations
- Gifu University (JP)
- Venue
- Journal of Nutritional Science and Vitaminology
- Published
- 2007
- Volume
- 53
- Issue
- 1
- Pages
- 37-42
- ISSN
- 0301-4800 (ISSN-L)
- 1881-7742
- OpenAlex
- W2087569500
- Cited by
- 149
- References
- 25
- Citations by year
- 2026: 9 · 2025: 14 · 2024: 14 · 2023: 12 · 2022: 17 · 2021: 16 · 2020: 11 · 2019: 8 · 2018: 11 · 2017: 6 · 2016: 4 · 2015: 9 · 2014: 3 · 2013: 3 · 2012: 2
- FWCI
- 1.78
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- Journal of Nutritional Science and Vitaminology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Aging, Health, and Disability
- Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
- Keywords
- serum albumin, aging, hypoalbuminemia, older adults, community-dwelling older adults, sex differences, nutritional status
- MeSH terms
- Activities of Daily Living, Age Factors, Aged, Aged, 80 and over, Aging, Analysis of Variance, Community Health Services, Cross-Sectional Studies, Female, Follow-Up Studies, Humans, Japan, Longitudinal Studies, Male, Population Surveillance, Research Design, Residence Characteristics, Serum Albumin, Sex Factors, Biomarkers, Incidence, Linear Models, Hypoalbuminemia
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
