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Relationship between Serum Albumin Level and Aging in Community-Dwelling Self-Supported Elderly Population
Open accessAbstract
While lower serum albumin concentration is often found in the elderly, a relation between serum albumin and age has not been fully elucidated. We conducted population-based cross-sectional and 5-y longitudinal study to examine the relation. A total of 22,705 male and 40,149 female, aged 65 y and older, living in Gifu, participated in the health check service conducted by Gifu City Medical Association. They were self-supported in the activity of daily living and 3,438 of them were followed up every year from 1999 to 2003. Serum albumin levels decreased with age in both men and women. In the cross-sectional study, median value declined from 4.3 g/dL in males aged 65-69 y to 3.9 g/dL in 90< or = y, and 4.3 g/dL to 4.0 g/dL in females. Incidence of hypoalbuminemia (serum albumin < or =3.5 g/dL) increased in parallel with age from 1.2% (65-69 y) to 6.6% (85-89) in males, and 0.6% to 4.1% in females. In the longitudinal study, regression analysis showed a significant decline in serum albumin of 0.015 g/dL per year (r= -0.716) in males, and 0.012 g/ dL per year (r= -0.794) in females. Relative reduction of serum albumin in 5 y was larger in advanced age; 1.2% in females aged 65-69 y and 3.1% in 85-89 y (p<0.05), but not in males. In conclusion, a fall in serum albumin concentration in community-dwelling, self-supported elderly persons was associated significantly with aging.
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“Serum albumin levels decrease with age,318 possibly increasing Aβ deposition in the brain, as albumin is able to sequester Aβ from the blood.319”
From Antiageing strategy for neurodegenerative diseases: from mechanisms to clinical advances (2025) · cites this paper as [318]
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Metadata
- Authors
- GOMI, I., FUKUSHIMA, H., SHIRAKI, M., MIWA, Y., ANDO, T., TAKAI, K., & MORIWAKI, H.
- Affiliations
- Gifu University (JP)
- Venue
- Journal of Nutritional Science and Vitaminology
- Published
- 2007
- Volume
- 53
- Issue
- 1
- Pages
- 37-42
- ISSN
- 0301-4800 (ISSN-L)
- 1881-7742
- OpenAlex
- W2087569500
- Cited by
- 149
- References
- 25
- Citations by year
- 2026: 9 · 2025: 14 · 2024: 14 · 2023: 12 · 2022: 17 · 2021: 16 · 2020: 11 · 2019: 8 · 2018: 11 · 2017: 6 · 2016: 4 · 2015: 9 · 2014: 3 · 2013: 3 · 2012: 2
- FWCI
- 1.78
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- Journal of Nutritional Science and Vitaminology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Aging, Health, and Disability
- Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
- Keywords
- serum albumin, aging, hypoalbuminemia, older adults, community-dwelling older adults, sex differences, nutritional status
- MeSH terms
- Activities of Daily Living, Age Factors, Aged, Aged, 80 and over, Aging, Analysis of Variance, Community Health Services, Cross-Sectional Studies, Female, Follow-Up Studies, Humans, Japan, Longitudinal Studies, Male, Population Surveillance, Research Design, Residence Characteristics, Serum Albumin, Sex Factors, Biomarkers, Incidence, Linear Models, Hypoalbuminemia
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