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Cited by 216

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Cloning of Immunoglobulin-Producing Human Leukemic and Lymphoma Cells in Long-Term Cultures.

Hinuma, Y., Grace, J. T.·1967·Experimental Biology and Medicine

Abstract

Single cell clones were derived from 4 lines of human leukemia and Burkitt lymphoma cells in long-term culture by a semi-solid agar procedure. Some clonally derived cell strains were shown to produce only one component of heavy chain immunoglobulins and others produced 2 components as determined by immunofluorescence. One of 4 cell lines tested contained 2 different types of cells. One cell type produced only Ig M. The other cell type produced both Ig M and Ig G. All of the clones derived from 3 other cell lines produced the same immunoglobulins as their parent cultures.

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Metadata

Authors
Hinuma, Y., & Grace, J. T.
Venue
Experimental Biology and Medicine
Published
1967-01-01
Volume
124
Issue
1
Pages
107-111
ISSN
  • 0071-3384 (ISSN-L)
  • 1535-3702
  • 1535-3699
OpenAlex
W2320954544
Cited by
216
References
0
FWCI
18.23
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Cloning of Immunoglobulin-Producing Human Leukemic and Lymphoma Cells in Long-Term Cultures. https://app.cochat.ai/papers/10.3181/00379727-124-31677
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Hinuma, Y., & Grace, J. T. (1967). Cloning of Immunoglobulin-Producing Human Leukemic and Lymphoma Cells in Long-Term Cultures. Experimental Biology and Medicine. https://doi.org/10.3181/00379727-124-31677

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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.