Conditioned insulin secretion in the albino rat
Abstract
SummaryAlthough the phenomenon of conditioned hypoglycemia is now well established, little is known about its mechanism. The present experiments lead to the conclusion that the mechanism involves a release of insulin: Experiment 1 showed that rats given an injection of streptozotocin, a drug which destroys the beta cells of the islets of Langerhans, did not show a conditioned hypoglycemia, whereas rats given only the vehicle for the streptozotocin did; and in experiment 2, blood drawn from conditioned rats just before the conditioned hypoglycemia would normally occur showed greater insulinlike activity than blood drawn from control rats. These results demonstrate a conditioned release of some hypoglycemic agent that depends upon the integrity of the beta cells. A neural control over release of insulin must be inferred to explain them.This study was supported by the USPHS Training Grant No. 5TO1 GM 00666. Thanks are due to Dr. Clara A. Muehlbaecher and to Dr. Daniel Porte, Jr. for their helpful comments; t...
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Evidence indicates that hormones linked to metabolic processes such as insulin and ghrelin can be conditioned and initiate anticipatory allostatic processes.
“Further, evidence indicates that hormones linked to metabolic processes such as insulin (Woods et al., 1970) and ghrelin (Drazen et al., 2006) can be conditioned and initiate anticipatory allostatic processes.”
From Active Inference, homeostatic regulation and adaptive behavioural control (2015) · cites this paper as Woods et al., 1970
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- Authors
- Woods, S. C., Hutton, R. A., & Makous, W.
- Affiliations
- University of Washington (US)
- Venue
- Experimental Biology and Medicine
- Publisher
- Frontiers Media SA
- Published
- 1970-03-01
- Volume
- 133
- Issue
- 3
- Pages
- 964-968
- ISSN
- 0071-3384 (ISSN-L)
- 1535-3702
- 1535-3699
- OpenAlex
- W2318803739
- Cited by
- 54
- References
- 0
- Citations by year
- 2020: 1 · 2016: 1 · 2015: 2 · 2013: 4
- FWCI
- 7.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Experimental Biology and Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Keywords
- insulin secretion, streptozotocin, islet damage, albino rats
- MeSH terms
- Insulin Secretion, Animals, Antibiotics, Antineoplastic, Diabetes Mellitus, Diaphragm, Glucose, Hypoglycemia, Insulin, Islets of Langerhans, Male, Muscles, Rats
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