Biological consequences of drug administration: Implications for acute and chronic tolerance

Ramsay, Douglas S.; Woods, Stephen C.

doi:10.1037/0033-295x.104.1.170

Cited by 155Neurotransmitter Receptor Influence on BehaviorSubstance Abuse Treatment and OutcomesNeuroscience and Neuropharmacology Research

Biological consequences of drug administration: Implications for acute and chronic tolerance

Ramsay, Douglas S., Woods, Stephen C.·1997·Psychological Review

DOI 10.1037/0033-295x.104.1.170

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Abstract

The authors presented a model that extrapolates the biological consequences of drug administration to account for acute and chronic tolerance. Drug-induced changes of regulated parameters provide detectable perturbations to which the brain responds. With experience, these centrally mediated responses are learned and can be activated in the absence of the drug-induced perturbation. Although neural responses following drug administration are often obscured, the model shows how these responses may be identified and provides a reinterpretation of drug conditioning paradigms. The authors made comparisons between the present empirical model of drug administration and existing theories of drug tolerance. The authors also presented a unified framework for understanding the consequences of repeated drug use and made specific predictions as to the relationships among acute and chronic tolerance, drug sensitization, and individual differences in vulnerability to drug addiction.

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Addiction
Robinson, T. E., & Berridge, K. C. (2003) · Annual Review of Psychology · doi:10.1146/annurev.psych.54.101601.145237 · Cited by 1,509 · see citing works
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Progressive enhancement of delayed hyperalgesia induced by repeated heroin administration: a sensitization process
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The Timing of Meals.
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Applying laboratory research: Drug anticipation and the treatment of drug addiction.
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Elevated levels of impulsivity and reduced place conditioning with d-amphetamine: Two behavioral features of adolescence in mice.
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Measuring the emergence of tobacco dependence: the contribution of negative reinforcement models
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Appetitive nature of drug cues confirmed with physiological measures in a model using pictures of smoking
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Anticipatory nausea and vomiting due to chemotherapy
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A unique hormonal and behavioral hyporesponsivity to both forced novelty and d-amphetamine in periadolescent mice
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Agonist induced homologous desensitization of mu-opioid receptors mediated by G protein-coupled receptor kinases is dependent on agonist efficacy.
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A Prospective 5-Year Re-examination of Alcohol Response in Heavy Drinkers Progressing in Alcohol Use Disorder
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Utilizing placebo mechanisms for dose reduction in pharmacotherapy
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Homeostasis: Beyond Curt Richter
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Pavlovian influences over food and drug intake
Woods, S. C., & Ramsay, D. S. (2000) · Behavioural Brain Research · doi:10.1016/s0166-4328(99)00194-1 · Cited by 99 · see citing works
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Human nicotine conditioning requires explicit contingency knowledge: is addictive behaviour cognitively mediated?
Hogarth, L., & Duka, T. (2005) · Psychopharmacology · doi:10.1007/s00213-005-0150-0 · Cited by 97 · see citing works
Pain facilitatory circuits in the mammalian central nervous system: their behavioral significance and role in morphine analgesic tolerance
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Pavlovian Conditioning of Immunological and Neuroendocrine Functions
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Direct animal calorimetry, the underused gold standard for quantifying the fire of life
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Agonist Induced Homologous Desensitization of μ-Opioid Receptors Mediated by G Protein-Coupled Receptor Kinases Is Dependent on Agonist Efficacy
Kovoor, A., Celver, J. P., Wu, A. Y., & Chavkin, C. (1998) · Molecular Pharmacology · doi:10.1016/s0026-895x(24)13072-6 · Cited by 80 · see citing works
Physiological and behavioral effects of acute ethanol hangover in juvenile, adolescent, and adult rats.
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Acquiring Symptoms in Response to Odors: A Learning Perspective on Multiple Chemical Sensitivity
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Evolution meets biopsychosociality: an analysis of addictive behavior
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Pavlovian conditioning of nausea and vomiting
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Role of classical conditioning in learning gastrointestinal symptoms
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Maternal separation affects cocaine-induced locomotion and response to novelty in adolescent, but not in adult rats
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Anticipatory Symptoms and Anticipatory Immune Responses in Pediatric Cancer Patients Receiving Chemotherapy: Features of a Classically Conditioned Response?
Stockhorst, U., Spennes-Saleh, S., Körholz, D., Göbel, U., Schneider, M. E., Steingrüber, H.-J., & Klosterhalfen, S. (2000) · Brain Behavior and Immunity · doi:10.1006/brbi.1999.0581 · Cited by 55 · see citing works
The relation between dopamine oxidation currents in the nucleus accumbens and conditioned increases in motor activity in rats following repeated administration of d‐amphetamine or cocaine
Ciano, P. D., Blaha, C. D., & Phillips, A. G. (1998) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1998.00124.x · Cited by 54 · see citing works
Food intake, metabolism and homeostasis
Woods, S. C., & Ramsay, D. S. (2011) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.04.026 · Cited by 50 · see citing works
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Dynamic changes in reinforcer effectiveness: Satiation and habituation have different implications for theory and practice
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Aspects of the Relationship between Drug Dose and Drug Effect
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Effects of third intracerebroventricular injections of corticotropin- releasing factor (CRF) on ethanol drinking and food intake
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Do adolescent smokers experience withdrawal effects when deprived of nicotine?
Killen, J. D., Ammerman, S. D., Rojas, N. L., Varady, J. C., Haydel, F., & Robinson, T. N. (2001) · Experimental and Clinical Psychopharmacology · doi:10.1037//1064-1297.9.2.176 · Cited by 45 · see citing works
Classically conditioned responses following repeated insulin and glucose administration in humans
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Interoception, conditioning, and fear: The panic threesome
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Locomotor activation by theacrine, a purine alkaloid structurally similar to caffeine: Involvement of adenosine and dopamine receptors
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Conditioned compensatory response to ethanol as indicated by locomotor activity in rats
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Intra-Administration Associations and Withdrawal Symptoms: Morphine-Elicited Morphine Withdrawal.
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Pavlovian conditioning of immune function: animal investigation and the challenge of human application
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Clonidine blocks acquisition but not expression of conditioned opiate withdrawal in rats
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Nitrous oxide analgesia in humans: acute and chronic tolerance
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Learning and Tolerance to the Ataxic Effect of Ethanol
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Classically conditioned changes in plasma cortisol levels induced by dexamethasone in healthy men
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Classical Conditioning of Insulin Effects in Healthy Humans
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Classical conditioning and conditionability of insulin and glucose effects in healthy humans
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The House Economist and the Eating Paradox
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Authors: Ramsay, D. S., & Woods, S. C.
Affiliations: University of Washington (US)
ORCID: Ramsay, Douglas S.
Woods, Stephen C.
Venue: Psychological Review
Publisher: American Psychological Association (APA)
Published: 1997-01
Volume: 104
Issue: 1
Pages: 170-193
ISSN: 0033-295X (ISSN-L)
1939-1471
DOI: 10.1037/0033-295x.104.1.170
OpenAlex: W1980751644
Cited by: 155
References: 149
Citations by year: 2026: 2 · 2025: 2 · 2024: 3 · 2023: 2 · 2021: 3 · 2020: 2 · 2019: 4 · 2018: 2 · 2017: 1 · 2016: 4 · 2015: 4 · 2014: 6 · 2013: 5 · 2012: 2
FWCI: 4.46
Type: journal article
Language: en
Open access: closed
Locations: Psychological Review (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Drug Abuse (R29DA007391, DA 07391)
National Institute of Dental and Craniofacial Research (DE-00379, K16DE000161, DE 00161)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: drug tolerance, acute tolerance, drug sensitization, drug conditioning, drug addiction vulnerability, individual differences
MeSH terms: Animals, Brain, Conditioning, Classical, Drug Tolerance, Humans, Substance-Related Disorders

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Biological consequences of drug administration: Implications for acute and chronic tolerance

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