Intranasal instillation of oxytocin increases insulin and glucagon secretion
Abstract
Intravenously administered oxytocin was found to increase plasma insulin and glucagon levels. To explore if the same effects could be obtained by nonparenteral routes of administration, oxytocin was given by nasal instillation in normal conscious dogs. Plasma glucose, insulin, and glucagon levels all increased to levels which previously were shown to cause increased glucose production and utilization. Vasopressin infusion had no effect on these measurements. This is the first report of the effectiveness of oxytocin to evoke insulin and glucagon secretion by the nasal route of administration.
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In dogs, intranasal oxytocin increases glucagon and insulin secretion, probably through peripheral actions, since intravenous oxytocin has similar effects in goats and dogs.
“Intranasal application in dogs increases glucagon and insulin secretion (37), and this is probably mediated peripherally as intravenous oxytocin has a similar effect in goats (38) and dogs (39).”
From Intranasal Oxytocin: Myths and Delusions (2016) · cites this paper as [37]
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The oxytocin receptor: from intracellular signaling to behavior
Jurek, B., & Neumann, I. D. (2018) · Physiological Reviews · doi:10.1152/physrev.00031.2017 · Cited by 999 · see citing works
Intranasal Oxytocin: Myths and Delusions
Leng, G., & Ludwig, M. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.05.003 · Cited by 615 · see citing works
Maejima, Y., Rita, R. S., Santoso, P., Aoyama, M., Hiraoka, Y., Nishimori, K., Gantulga, D., Shimomura, K., & Yada, T. (2015) · Neuroendocrinology · doi:10.1159/000371636 · Cited by 81 · see citing works
- Authors
- Altszuler, N., & Hampshire, J.
- Affiliations
- New York University (US)
- Venue
- Experimental Biology and Medicine
- Publisher
- Frontiers Media SA
- Published
- 1981-10-01
- Volume
- 168
- Issue
- 1
- Pages
- 123-124
- ISSN
- 0071-3384 (ISSN-L)
- 1535-3702
- 1535-3699
- OpenAlex
- W2087569442
- Cited by
- 19
- References
- 0
- Citations by year
- 2024: 2 · 2023: 1 · 2021: 1 · 2019: 1 · 2018: 1 · 2016: 3 · 2015: 2
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Experimental Biology and Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- oxytocin, intranasal administration, insulin secretion, glucagon secretion, plasma glucose, vasopressin, glucose metabolism, dogs
- MeSH terms
- Administration, Intranasal, Animals, Blood Glucose, Dogs, Glucagon, Insulin, Oxytocin
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