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Propionate May Mediate the Hypocholesterolemic Effects of Certain Soluble Plant Fibers in Cholesterol-Fed Rats
Abstract
The effects of propionate on serum and liver lipid concentrations were studied in cholesterol-fed rats. Both serum and liver cholesterol levels were significantly lower in rats fed the cholesterol-propionate diet than in rats fed the cholesterol diet without propionate. Liver triglyceride levels were also significantly lower in the propionate-treated group. Serum triglyceride concentrations were not influenced by the propionate feeding. Propionate intake was not associated with histologic changes in liver tissue. This study indicates that 0.5% sodium propionate-supplemented diets slightly but significantly reduced cholesterol accumulation in both serum and liver of cholesterol-fed rats. Thus propionate, a metabolic product of fiber fermentation, may mediate some of the hypocholesterolemic effects of certain soluble plant fibers.
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Citations
Cited by
Topping, D. L., & Clifton, P. M. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.3.1031 · Cited by 3,091
Energy contributions of volatile fatty acids from the gastrointestinal tract in various species
Bergman, E. N. (1990) · Physiological Reviews · doi:10.1152/physrev.1990.70.2.567 · Cited by 2,750
Colonic Health: Fermentation and Short Chain Fatty Acids
Wong, J. M. W., de Souza, R., Kendall, C. W. C., Emam, A., & Jenkins, D. J. A. (2006) · Journal of Clinical Gastroenterology · doi:10.1097/00004836-200603000-00015 · Cited by 2,739
Phillips, G. O., & Williams, P. A. (2009) · Woodhead Publishing Limited eBooks · doi:10.1533/9781845695873 · Cited by 2,105
The control and consequences of bacterial fermentation in the human colon
Cummings, J. H., & Macfarlane, G. T. (1991) · Journal of Applied Bacteriology · doi:10.1111/j.1365-2672.1991.tb02739.x · Cited by 1,499
Metadata
- Authors
- Chen, W.-J. L., Anderson, J. W., & Jennings, D.
- Venue
- Experimental Biology and Medicine
- Publisher
- Frontiers Media SA
- Published
- 1984-02-01
- Volume
- 175
- Issue
- 2
- Pages
- 215-218
- ISSN
- 0071-3384 (ISSN-L)
- 1535-3702
- 1535-3699
- OpenAlex
- W2056658113
- Cited by
- 439
- References
- 0
- FWCI
- 5.67
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Propionate May Mediate the Hypocholesterolemic Effects of Certain Soluble Plant Fibers in Cholesterol-Fed Rats. https://app.cochat.ai/papers/10.3181/00379727-175-41791
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- Chen, W.-J. L., Anderson, J. W., & Jennings, D. (1984). Propionate May Mediate the Hypocholesterolemic Effects of Certain Soluble Plant Fibers in Cholesterol-Fed Rats. Experimental Biology and Medicine. https://doi.org/10.3181/00379727-175-41791
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
