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Type I and Type III Collagen Content of Healing Wounds in Fetal and Adult Rats
Abstract
Full-thickness, dermal wounds were surgically created on the dorsa of fetal rats on the 17th day of gestation. The granulation tissue which developed after 2 days (19 days of gestation) was harvested from six to nine animals and pooled and the collagen was extracted with 0.5 M acetic acid and acetic acid plus pepsin. The ratio of type III:type I collagen was estimated from densitometer scans of electrophoretically separated alpha-chains. Full-thickness (to fascia depth) wounds were also produced on the dorsa of adult rats and granulation tissue which had developed for different periods of time up to 30 days was excised. Relative proportions of type III and type I collagen were assessed in normal and granulation tissues taken from the adult rats. Both fetal and adult granulation tissues have elevated type III collagen content but normal fetal tissue has a much higher content of type III than does normal adult tissue.
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Cited by
Wound Healing: A Cellular Perspective
Rodrigues, M., Kosaric, N., Bonham, C. A., & Gurtner, G. C. (2019) · Physiological Reviews · doi:10.1152/physrev.00067.2017 · Cited by 3,013
Extracellular Matrix Reorganization During Wound Healing and Its Impact on Abnormal Scarring
Xue, M., & Jackson, C. J. (2015) · Advances in Wound Care · doi:10.1089/wound.2013.0485 · Cited by 1,468
Extracellular Matrix and Dermal Fibroblast Function in the Healing Wound
Tracy, L. E., Minasian, R. A., & Caterson, E. J. (2016) · Advances in Wound Care · doi:10.1089/wound.2014.0561 · Cited by 1,008
Scarless Fetal Wound Healing: A Basic Science Review
Larson, B. J., Longaker, M. T., & Lorenz, H. P. (2010) · Plastic and Reconstructive Surgery · doi:10.1097/prs.0b013e3181eae781 · Cited by 454
The interplay of fibroblasts, the extracellular matrix, and inflammation in scar formation
Moretti, L., Stalfort, J., Barker, T. H., & Abebayehu, D. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.101530 · Cited by 393
Metadata
- Authors
- Merkel, J. R., DiPaolo, B. R., Hallock, G. G., & Rice, D. C.
- Venue
- Experimental Biology and Medicine
- Publisher
- Frontiers Media SA
- Published
- 1988-04-01
- Volume
- 187
- Issue
- 4
- Pages
- 493-497
- ISSN
- 0071-3384 (ISSN-L)
- 1535-3702
- 1535-3699
- OpenAlex
- W2312909112
- Cited by
- 227
- References
- 0
- FWCI
- 5.32
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Type I and Type III Collagen Content of Healing Wounds in Fetal and Adult Rats. https://app.cochat.ai/papers/10.3181/00379727-187-42694
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- Merkel, J. R., DiPaolo, B. R., Hallock, G. G., & Rice, D. C. (1988). Type I and Type III Collagen Content of Healing Wounds in Fetal and Adult Rats. Experimental Biology and Medicine. https://doi.org/10.3181/00379727-187-42694
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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