Extracellular Matrix and Dermal Fibroblast Function in the Healing Wound

Tracy, Lauren E.; Minasian, Raquel A.; Caterson, E.J.

doi:10.1089/wound.2014.0561

Cited by 1,008Wound Healing and TreatmentsConnective Tissue Growth Factor ResearchElectrospun Nanofibers in Biomedical Applications

Extracellular Matrix and Dermal Fibroblast Function in the Healing Wound

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Tracy, Lauren E., Minasian, Raquel A., Caterson, E.J.·2016·Advances in Wound Care

DOI 10.1089/wound.2014.0561PMC PMC4779293

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Abstract

Significance: Fibroblasts play a critical role in normal wound healing. Various extracellular matrix (ECM) components, including collagens, fibrin, fibronectin, proteoglycans, glycosaminoglycans, and matricellular proteins, can be considered potent protagonists of fibroblast survival, migration, and metabolism. Recent Advances: Advances in tissue culture, tissue engineering, and ex vivo models have made the examination and precise measurements of ECM components in wound healing possible. Likewise, the development of specific transgenic animal models has created the opportunity to characterize the role of various ECM molecules in healing wounds. In addition, the recent characterization of new ECM molecules, including matricellular proteins, dermatopontin, and FACIT collagens (Fibril-Associated Collagens with Interrupted Triple helices), further demonstrates our cursory knowledge of the ECM in coordinated wound healing. Critical Issues: The manipulation and augmentation of ECM components in the healing wound is emerging in patient care, as demonstrated by the use of acellular dermal matrices, tissue scaffolds, and wound dressings or topical products bearing ECM proteins such as collagen, hyaluronan (HA), or elastin. Once thought of as neutral structural proteins, these molecules are now known to directly influence many aspects of cellular wound healing. Future Directions: The role that ECM molecules, such as CCN2, osteopontin, and secreted protein, acidic and rich in cysteine, play in signaling homing of fibroblast progenitor cells to sites of injury invites future research as we continue investigating the heterotopic origin of certain populations of fibroblasts in a healing wound. Likewise, research into differently sized fragments of the same polymeric ECM molecule is warranted as we learn that fragments of molecules such as HA and tenascin-C can have opposing effects on dermal fibroblasts.

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Collagen type I is the major constituent of the dermis, interlaced with other important ECM components such as collagen III and VII, fibronectin, vitronectin, hyaluronic acid, and glycosaminoglycans, such as heparin.
“Unlike Matrigel, the major constituent of the dermis is collagen type I, which is interlaced with other important ECM components such as collagen III and VII [23,24], fibronectin [25], vitronectin [11], hyaluronic acid [26,27], and glycosaminoglycans, such as heparin [28], all of which contribute to key physiological skin functions.”
From Efficient Generation of Skin Organoids from Pluripotent Cells via Defined Extracellular Matrix Cues and Morphogen Gradients in a Spindle‐Shaped Microfluidic Device (2024) · cites this paper as [25]

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Authors: Tracy, L. E., Minasian, R. A., & Caterson, E. J.
Affiliations: Brigham and Women's Hospital (US)
ORCID: Caterson, E.J.
Venue: Advances in Wound Care
Publisher: SAGE Publications
Published: 2016-03
Volume: 5
Issue: 3
Pages: 119-136
ISSN: 2162-1918 (ISSN-L)
2162-1934
DOI: 10.1089/wound.2014.0561
PMC: PMC4779293
OpenAlex: W2004098988
Cited by: 1,008
References: 194
Citations by year: 2026: 82 · 2025: 130 · 2024: 132 · 2023: 126 · 2022: 130 · 2021: 124 · 2020: 104 · 2019: 65 · 2018: 59 · 2017: 42 · 2016: 13
FWCI: 2.28
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Advances in Wound Care (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Connective Tissue Growth Factor Research
Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
Keywords: extracellular matrix, dermal fibroblasts, wound healing, collagen, fibrin, fibronectin, proteoglycans, glycosaminoglycans, matricellular proteins, dermatopontin, acellular dermal matrix, tissue engineering scaffolds, wound dressings, hyaluronic acid, elastin, osteopontin, connective tissue growth factor, SARC, tenascin-C, fibroblast migration, transgenic animal models

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Extracellular Matrix and Dermal Fibroblast Function in the Healing Wound

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